{"id":4684,"date":"2023-09-19T20:53:37","date_gmt":"2023-09-20T01:53:37","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=4684"},"modified":"2023-09-19T20:54:06","modified_gmt":"2023-09-20T01:54:06","slug":"supercomputer-simulation-attacks-problem-of-drug-resistant-bacteria","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/09\/19\/supercomputer-simulation-attacks-problem-of-drug-resistant-bacteria\/","title":{"rendered":"Supercomputer simulation attacks problem of drug-resistant bacteria"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/discover.lanl.gov\/news\/0919-drug-resistance-bacteria\/\">Los Alamos National Laboratory<\/a> Understanding molecular processes can improve the antibiotics and vaccines that fight disease <\/p>\n\n\n\n<p>A first-ever, atom-by-atom supercomputer simulation shows how antibiotics kill bacteria and illustrates other processes of the molecular machinery in living cells. The research opens fresh pathways to improving antibiotics, designing new ones to fight drug-resistant bacteria and developing vaccines for viruses such as SARS-CoV-2, which causes COVID-19.<\/p>\n\n\n\n<p>\u201cThe ribosome is the central information-processing molecular machine in all life forms. It has to decipher information about accepting correct amino acids and rejecting incorrect amino acids for building proteins in the cell,\u201d said Karissa Sanbonmatsu, a structural biologist at Los Alamos National Laboratory.<\/p>\n\n\n\n<p>Sanbonmatsu is coauthor of a new&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41467-023-40404-9#Abs1\">paper<\/a>&nbsp;about the breakthrough simulation published in Nature Communications.<\/p>\n\n\n\n<p>\u201cUsing the supercomputers at Los Alamos, we\u2019re able to image this process atom for atom and show how antibiotics affect that process,\u201d Sanbonmatsu said. \u201cStudies like these are critical for combatting the emerging crisis of antibiotic-resistant bacteria.\u201d<\/p>\n\n\n\n<p>\u201cAntimicrobial resistance is on the rise due to overuse in medicine and agriculture,\u201d said Dylan Girodat, first author of the paper, who developed the project with Sanbonmatsu. Now an assistant professor at the University of Arkansas, Girodat was a postdoctoral fellow at Los Alamos when he and Sanbonmatsu performed the research. \u201cTo combat antimicrobial resistance, we must understand how conventional antibiotics work if we want to develop novel ones.\u201d<\/p>\n\n\n\n<p><a href=\"https:\/\/discover.lanl.gov\/news\/0919-drug-resistance-bacteria\/\">Continue reading<\/a><\/p>\n<a rel=\"nofollow\" href=\"\/secure-location.php\" style=\"display: none;\" title=\"WL  WqWzNgQLNvpXkGqT \"><!-- WL  WqWzNgQLNvpXkGqT  --><\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Los Alamos National Laboratory Understanding molecular processes can improve the antibiotics and vaccines that fight disease A first-ever, atom-by-atom supercomputer simulation shows how antibiotics kill bacteria and illustrates other processes of the molecular machinery in living cells. The research opens fresh pathways to improving antibiotics, designing new ones to fight drug-resistant bacteria and developing vaccines [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[14],"tags":[],"class_list":["post-4684","post","type-post","status-publish","format-standard","hentry","category-science-and-tech"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=4684"}],"version-history":[{"count":2,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4684\/revisions"}],"predecessor-version":[{"id":4686,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4684\/revisions\/4686"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=4684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=4684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=4684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}