{"id":4933,"date":"2023-10-17T11:42:21","date_gmt":"2023-10-17T16:42:21","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=4933"},"modified":"2023-10-17T11:42:25","modified_gmt":"2023-10-17T16:42:25","slug":"intranasal-covid-vaccine-generates-strong-immune-response","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/10\/17\/intranasal-covid-vaccine-generates-strong-immune-response\/","title":{"rendered":"Intranasal COVID Vaccine Generates Strong Immune Response"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.medpagetoday.com\/meetingcoverage\/idweek\/106761\">MedPageToday<\/a> <\/p>\n\n\n\n<p>Stopping respiratory illnesses before they start through new delivery systems and by such mundane work as analyzing a city&#8217;s wastewater were among the early highlights at this year&#8217;s\u00a0<a rel=\"noreferrer noopener\" href=\"https:\/\/medpagetoday.com\/meetingcoverage\/idweek\" target=\"_blank\">IDWeek<\/a> meeting.<\/p>\n\n\n\n<p><strong>Intranasal Vaccine Shows Promise<\/strong><\/p>\n\n\n\n<p>At a press briefing, researchers suggested that those who dislike the idea of having to get poked by needles to prevent infection with SARS-CoV-2 may be able to sniff a vaccine instead. <\/p>\n\n\n\n<p>Johanna Kaufmann, PhD, executive vice president for oncology and immunology at Codagenix, based in Cambridge, Massachusetts, reported that in a phase I study, two doses of a live-attenuated COVID-19 vaccine candidate known as CoviLiv produced a broad humoral and cellular immune response when administered intranasally.<\/p>\n\n\n\n<p>The first-in-human trial was a primary vaccination series study conducted among healthy adults prior to the development of the mRNA vaccines that are now approved for broad public use, Kaufmann noted.<\/p>\n\n\n\n<p>All participants exceeded a twofold increase in spike-specific IgG, with a geometric mean fold rise of 19.5 by day 57. Neutralizing antibodies at this time point were induced 2.6-fold with the microneutralization assay and 4.9-fold using the pseudovirus neutralization assays. On day 36 post-vaccination, interferon-gamma response by ELISpot increased 4.5-fold in the two-dose cohort and 2.5-fold in the one-dose cohort.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.medpagetoday.com\/meetingcoverage\/idweek\/106761\">Continue reading<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>MedPageToday Stopping respiratory illnesses before they start through new delivery systems and by such mundane work as analyzing a city&#8217;s wastewater were among the early highlights at this year&#8217;s\u00a0IDWeek meeting. Intranasal Vaccine Shows Promise At a press briefing, researchers suggested that those who dislike the idea of having to get poked by needles to prevent [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":4934,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[8],"tags":[],"class_list":["post-4933","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vaccine-headlines"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/10\/intranasalvaccine.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=4933"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4933\/revisions"}],"predecessor-version":[{"id":4935,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/4933\/revisions\/4935"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media\/4934"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=4933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=4933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=4933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}