{"id":5074,"date":"2023-10-31T16:13:57","date_gmt":"2023-10-31T21:13:57","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=5074"},"modified":"2023-10-31T16:14:00","modified_gmt":"2023-10-31T21:14:00","slug":"neurotropic-highly-pathogenic-avian-influenza-ah5n1-virus-in-red-foxes-northern-germany","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/10\/31\/neurotropic-highly-pathogenic-avian-influenza-ah5n1-virus-in-red-foxes-northern-germany\/","title":{"rendered":"Neurotropic Highly Pathogenic Avian Influenza A(H5N1) Virus in Red Foxes, Northern Germany"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article\">CDC<\/a> <\/p>\n\n\n\n<p>In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January\u2012March 2023. Encephalitis and strong cerebral virus replication but only sporadic mammalian-adaptive viral polymerase basic 2 protein E627K mutations were seen.<\/p>\n\n\n\n<p>Since emergence of the highly pathogenic avian influenza virus (HPAIV) H5 A\/Goose\/Guangdong\/1\/1996 (gs\/GD) lineage in 1996, successors continue to circulate in waves around the world, leading to massive losses in wild bird and domestic poultry populations (<a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r1\"><em>1<\/em><\/a>). Until 2020\u20122021, gs\/GD HPAIV infections in poultry holdings characteristically paralleled waterfowl migration patterns. Since then, this seasonality has virtually disappeared and gs\/GD HPAIV, currently of subtype H5N1 assigned to clade 2.3.4.4b, are detected year-round in wild birds and poultry in Europe (<a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r2\"><em>2<\/em><\/a><em>,<\/em><a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r3\"><em>3<\/em><\/a>). The virus has been found at increasing frequency in domestic and wild living mammals, mostly affecting carnivorous species (<a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r4\"><em>4<\/em><\/a>) and massive die-off events raised concern about potential mammal-to-mammal transmission in dense populations (<a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r5\"><em>5<\/em><\/a><em>,<\/em><a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r6\"><em>6<\/em><\/a>). HPAIV infections were regularly characterized by high viral loads in the brain and associated clinical signs of the central nervous system with corresponding morphologic changes (<a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r7\"><em>7<\/em><\/a><em>\u2013<\/em><a href=\"https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/12\/23-0938_article#r11\"><em>11<\/em><\/a>). Although Germany has had high HPAIV infection rates in avian species, prevalence studies on HPAIV infections in terrestrial predators, which feed on (infected) waterfowl, are not available. We performed a 1 year-survey to detect HPAIV in wild terrestrial predators in northern Germany.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>CDC In a 1-year survey of wild terrestrial predators in northern Germany, we found that 5 of 110 foxes were infected with contemporary avian influenza A(H5N1) viruses, forming a temporal cluster during January\u2012March 2023. Encephalitis and strong cerebral virus replication but only sporadic mammalian-adaptive viral polymerase basic 2 protein E627K mutations were seen. Since emergence [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":5075,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[37],"tags":[],"class_list":["post-5074","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avian-influenza"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/10\/Screenshot-2023-10-31-at-17.13.25.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/5074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=5074"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/5074\/revisions"}],"predecessor-version":[{"id":5076,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/5074\/revisions\/5076"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media\/5075"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=5074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=5074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=5074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}