{"id":5535,"date":"2023-12-12T21:12:18","date_gmt":"2023-12-13T03:12:18","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=5535"},"modified":"2023-12-12T21:12:21","modified_gmt":"2023-12-13T03:12:21","slug":"prion-disease-rising-in-the-u-s","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2023\/12\/12\/prion-disease-rising-in-the-u-s\/","title":{"rendered":"Prion Disease Rising in the U.S."},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.medpagetoday.com\/neurology\/generalneurology\/107790\">MedPage Today<\/a> Incidence of Creutzfeldt-Jakob disease increased, especially among women. <\/p>\n\n\n\n<p>The incidence of Creutzfeldt-Jakob disease (CJD), a universally fatal prion disease that progresses rapidly, rose consistently from 2007 to 2020, a study of death certificates showed.<\/p>\n\n\n\n<p>CJD codes on death certificates totaled 5,882 during that period, with 51.2% of cases occurring among women, according to John Probasco, MD, and Matthew Crane, BS, both of Johns Hopkins School of Medicine in Baltimore, and co-authors.<\/p>\n\n\n\n<p>From 2007 to 2020, the incidence climbed from 1.06 to 1.58 per million in women (<em>P<\/em>&lt;0.001) and from 1.05 to 1.47 per million in men (<em>P<\/em>=0.001). <\/p>\n\n\n\n<p>After adjusting for age, the increase in incidence was not significant for men (<em>P<\/em>=0.25) but remained significant for women (<em>P<\/em>=0.045), Probasco and colleagues reported in a\u00a0<a href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2812784\" target=\"_blank\" rel=\"noreferrer noopener\"><em>JAMA Neurology<\/em><\/a>\u00a0research letter.<\/p>\n\n\n\n<p>&#8220;Our findings indicate the reported incidence of CJD has risen considerably, disproportionately affecting older and female individuals,&#8221; the researchers observed.<\/p>\n\n\n\n<p>CJD is the most common form of human prion disease. Approximately\u00a0<a href=\"https:\/\/www.ninds.nih.gov\/health-information\/disorders\/creutzfeldt-jakob-disease\" target=\"_blank\" rel=\"noreferrer noopener\">85% of cases are sporadic<\/a>\u00a0and 15% are genetic. About 70% of people with CJD die within 1 year.<\/p>\n\n\n\n<p>CJD presents as a rapidly progressing dementia and tends to strike people 60 and older.\u00a0<a href=\"https:\/\/www.cdc.gov\/prions\/vcjd\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">Variant CJD<\/a>, an infectious type linked to bovine spongiform encephalopathy or &#8220;mad cow&#8221; disease, was first detected in the U.K. in the mid-1990s and usually affects younger people. Four cases of variant CJD have been\u00a0<a href=\"https:\/\/www.cdc.gov\/prions\/vcjd\/vcjd-reported.html\" target=\"_blank\" rel=\"noreferrer noopener\">reported in the U.S<\/a>. since 2001. Other\u00a0<a href=\"https:\/\/www.cdc.gov\/prions\/cwd\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">animal prion diseases<\/a>\u00a0like chronic wasting disease may have the potential for zoonotic transmission to humans, but no human cases have been reported.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>MedPage Today Incidence of Creutzfeldt-Jakob disease increased, especially among women. The incidence of Creutzfeldt-Jakob disease (CJD), a universally fatal prion disease that progresses rapidly, rose consistently from 2007 to 2020, a study of death certificates showed. CJD codes on death certificates totaled 5,882 during that period, with 51.2% of cases occurring among women, according to [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":5536,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[6],"tags":[],"class_list":["post-5535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-headlines"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-12-at-22.10.07.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/5535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=5535"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/5535\/revisions"}],"predecessor-version":[{"id":5537,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/5535\/revisions\/5537"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media\/5536"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=5535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=5535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=5535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}