{"id":6185,"date":"2024-03-27T07:05:37","date_gmt":"2024-03-27T12:05:37","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=6185"},"modified":"2024-03-27T07:05:41","modified_gmt":"2024-03-27T12:05:41","slug":"household-transmission-dynamics-of-asymptomatic-sars-cov-2-infected-children-a-multinational-controlled-case-ascertained-prospective-study","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2024\/03\/27\/household-transmission-dynamics-of-asymptomatic-sars-cov-2-infected-children-a-multinational-controlled-case-ascertained-prospective-study\/","title":{"rendered":"Household Transmission Dynamics of Asymptomatic SARS-CoV-2\u2013Infected Children: A Multinational, Controlled Case-Ascertained Prospective Study"},"content":{"rendered":"
\n

Clinical Infectious Diseases<\/a> <\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Asymptomatic SARS-CoV-2 infection in children is highly prevalent but its acute and chronic implications have been minimally described.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

In this controlled case-ascertained household transmission study, we recruited asymptomatic children <18 years with SARS-CoV-2 nucleic acid testing performed at 12 tertiary care pediatric institutions in Canada and the United States. We attempted to recruit all test-positive children and 1 to 3 test-negative, site-matched controls. After 14 days\u2019 follow-up we assessed the clinical (ie, symptomatic) and combined (ie, test-positive, or symptomatic) secondary attack rates (SARs) among household contacts. Additionally, post\u2013COVID-19 condition (PCC) was assessed in SARS-CoV-2\u2013positive participating children after 90 days\u2019 follow-up.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

A total of 111 test-positive and 256 SARS-CoV-2 test-negative asymptomatic children were enrolled between January 2021 and April 2022. After 14 days, excluding households with co-primary cases, the clinical SAR among household contacts of SARS-CoV-2\u2013positive and \u2013negative index children was 10.6% (19\/179; 95% CI: 6.5%\u201316.1%) and 2.0% (13\/663; 95% CI: 1.0%\u20133.3%), respectively (relative risk = 5.4; 95% CI: 2.7\u201310.7). In households with a SARS-CoV-2\u2013positive index child, age <5 years, being pre-symptomatic (ie, developed symptoms after test), and testing positive during Omicron and Delta circulation periods (vs earlier) were associated with increased clinical and combined SARs among household contacts. Among 77 asymptomatic SARS-CoV-2\u2013infected children with 90-day follow-up, 6 (7.8%; 95% CI: 2.9%\u201316.2%) reported PCC.<\/p>\n\n\n\n

Conclusions<\/p>\n\n\n\n

Asymptomatic SARS-CoV-2\u2013infected children, especially those <5 years, are important contributors to household transmission, with 1 in 10 exposed household contacts developing symptomatic illness within 14 days. Asymptomatic SARS-CoV-2\u2013infected children may develop PCC.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Clinical Infectious Diseases Abstract Background Asymptomatic SARS-CoV-2 infection in children is highly prevalent but its acute and chronic implications have been minimally described. Methods In this controlled case-ascertained household transmission study, we recruited asymptomatic children <18 years with SARS-CoV-2 nucleic acid testing performed at 12 tertiary care pediatric institutions in Canada and the United States. […]<\/p>\n","protected":false},"author":11,"featured_media":6186,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[11,16],"tags":[],"class_list":["post-6185","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid","category-published-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-27-at-08.04.50.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/6185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=6185"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/6185\/revisions"}],"predecessor-version":[{"id":6187,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/6185\/revisions\/6187"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media\/6186"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=6185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=6185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=6185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}