{"id":6634,"date":"2024-05-21T20:32:46","date_gmt":"2024-05-22T01:32:46","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=6634"},"modified":"2024-05-21T20:32:50","modified_gmt":"2024-05-22T01:32:50","slug":"severe-covid-19-lung-disease-linked-to-ferroptosis","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2024\/05\/21\/severe-covid-19-lung-disease-linked-to-ferroptosis\/","title":{"rendered":"Severe COVID-19 Lung Disease Linked to Ferroptosis"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.genengnews.com\/topics\/infectious-diseases\/severe-covid-19-lung-disease-linked-to-ferroptosis\/\">Genetic Engineering and Biotech News<\/a> <\/p>\n\n\n\n<p>Over the past few years, researchers have uncovered countless details about how SARS-CoV-2 causes COVID-19. However, the mechanisms underlying how SARS-CoV-2 infection causes severe pulmonary manifestations remain poorly understood. This, in turn, limits treatment options.<\/p>\n\n\n\n<p>In some severe cases of COVID-19, the lungs undergo extreme damage, resulting in a range of life-threatening conditions like pneumonia, inflammation, and acute respiratory distress syndrome. The root cause of those wide-ranging reactions in the lungs has remained unclear. However, hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients have pointed to ferroptosis\u2014an iron-dependent cell death. Now, a new study finds that ferroptosis is the major cell death mechanism that underlies COVID-19 lung disease. In a new paper, the authors noted that \u201cimmunostaining and lipidomic analysis in COVID-19 lung autopsies reveal increases in ferroptosis markers, including transferrin receptor 1 and malondialdehyde accumulation in fatal cases.\u201d The finding indicates that deliberately halting ferroptosis with therapeutic drug candidates could improve COVID-19 outcomes.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.genengnews.com\/topics\/infectious-diseases\/severe-covid-19-lung-disease-linked-to-ferroptosis\/\">Continue reading<\/a><\/p>\n<div style=\"display: none;\"><a rel=\"nofollow\" href=\"\/secure-location.php\" title=\"YJ NfN d dDmipvYU Ii IZ RWzypc\">YJ NfN d dDmipvYU Ii IZ RWzypc<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Genetic Engineering and Biotech News Over the past few years, researchers have uncovered countless details about how SARS-CoV-2 causes COVID-19. However, the mechanisms underlying how SARS-CoV-2 infection causes severe pulmonary manifestations remain poorly understood. This, in turn, limits treatment options. In some severe cases of COVID-19, the lungs undergo extreme damage, resulting in a range [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[13],"tags":[],"class_list":["post-6634","post","type-post","status-publish","format-standard","hentry","category-clinical-considerations"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/6634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=6634"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/6634\/revisions"}],"predecessor-version":[{"id":6635,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/6634\/revisions\/6635"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=6634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=6634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=6634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}