{"id":7491,"date":"2024-08-28T08:27:15","date_gmt":"2024-08-28T13:27:15","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=7491"},"modified":"2024-08-28T08:27:19","modified_gmt":"2024-08-28T13:27:19","slug":"promising-mpox-drug-fails-in-trials-as-virus-spreads","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2024\/08\/28\/promising-mpox-drug-fails-in-trials-as-virus-spreads\/","title":{"rendered":"Promising Mpox Drug Fails in Trials as Virus Spreads"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/www.wired.com\/story\/a-promising-drug-for-mpox-just-failed-in-trials\/\">Wired<\/a> <strong>AS MPOX CONTINUES<\/strong>&nbsp;to&nbsp;<a href=\"https:\/\/www.wired.com\/story\/mpox-outbreak-global-public-health-emergency\/\">spread in Central Africa<\/a>, a promising antiviral drug to treat the infection has failed to improve patients\u2019 symptoms in a trial in the Democratic Republic of the Congo, the epicenter of the outbreak.<\/p>\n\n\n\n<p>In the trial, the drug tecovirimat, also known as TPOXX, did not alleviate the characteristic blisterlike rash seen in people with&nbsp;<a href=\"https:\/\/www.wired.com\/tag\/monkeypox\/\">mpox<\/a>, formerly known as monkeypox. In an unusual step, the US National Institute of Allergy and Infectious Diseases (NIAID), which sponsored the study, announced the initial findings&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/antiviral-tecovirimat-safe-did-not-improve-clade-i-mpox-resolution-democratic-republic-congo\">earlier this month<\/a>&nbsp;prior to the full results being peer reviewed and published in a scientific journal.<\/p>\n\n\n\n<p>Lori Dodd, branch chief of NIAID\u2019s clinical trials research and statistics branch, tells WIRED that the agency shared the initial results \u201cdue to the urgent need for scientific evidence on the use of tecovirimat for the treatment of mpox.\u201d That urgency, she says, was reinforced by the World Health Organization designating the mpox outbreak in Central Africa as a\u00a0<a href=\"https:\/\/www.who.int\/news\/item\/14-08-2024-who-director-general-declares-mpox-outbreak-a-public-health-emergency-of-international-concern\">global health emergency<\/a>\u00a0on August 14. It\u2019s the second such declaration in two years.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.wired.com\/story\/a-promising-drug-for-mpox-just-failed-in-trials\/\">Continue Reading<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Wired AS MPOX CONTINUES&nbsp;to&nbsp;spread in Central Africa, a promising antiviral drug to treat the infection has failed to improve patients\u2019 symptoms in a trial in the Democratic Republic of the Congo, the epicenter of the outbreak. In the trial, the drug tecovirimat, also known as TPOXX, did not alleviate the characteristic blisterlike rash seen in [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[12],"tags":[],"class_list":["post-7491","post","type-post","status-publish","format-standard","hentry","category-monkeypox"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/7491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=7491"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/7491\/revisions"}],"predecessor-version":[{"id":7492,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/7491\/revisions\/7492"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=7491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=7491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=7491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}