{"id":8474,"date":"2025-01-14T17:14:16","date_gmt":"2025-01-14T23:14:16","guid":{"rendered":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/?p=8474"},"modified":"2025-01-14T17:14:21","modified_gmt":"2025-01-14T23:14:21","slug":"incidence-and-prevalence-of-post-covid-19-myalgic-encephalomyelitis-a-report-from-the-observational-recover-adult-study","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/2025\/01\/14\/incidence-and-prevalence-of-post-covid-19-myalgic-encephalomyelitis-a-report-from-the-observational-recover-adult-study\/","title":{"rendered":"Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11606-024-09290-9\">Journal of Internal Medicine<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Background<\/h3>\n\n\n\n<p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) may occur after infection. How often people develop ME\/CFS after SARS-CoV-2 infection is unknown.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Objective<\/h3>\n\n\n\n<p>To determine the incidence and prevalence of post-COVID-19 ME\/CFS among adults enrolled in the Researching COVID to Enhance Recovery (RECOVER-Adult) study.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Design, Setting, and Participants<\/h3>\n\n\n\n<p>RECOVER-Adult is a longitudinal observational cohort study conducted across the U.S. We included participants who had a study visit at least 6 months after infection and had no pre-existing ME\/CFS, grouped as (1) acute infected, enrolled within 30 days of infection or enrolled as uninfected who became infected (<em>n<\/em>=4515); (2) post-acute infected, enrolled greater than 30 days after infection (<em>n<\/em>=7270); and (3) uninfected (1439).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Measurements<\/h3>\n\n\n\n<p>Incidence rate and prevalence of post-COVID-19 ME\/CFS based on the 2015 Institute of Medicine ME\/CFS clinical diagnostic criteria.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Results<\/h3>\n\n\n\n<p>The incidence rate of ME\/CFS in participants followed from time of SARS-CoV-2 infection was 2.66 (95% CI 2.63\u20132.70) per 100 person-years while the rate in matched uninfected participants was 0.93 (95% CI 0.91\u201310.95) per 100 person-years: a hazard ratio of 4.93 (95% CI 3.62\u20136.71). The proportion of all RECOVER-Adult participants that met criteria for ME\/CFS following SARS-CoV-2 infection was 4.5% (531 of 11,785) compared to 0.6% (9 of 1439) in uninfected participants. Post-exertional malaise was the most common ME\/CFS symptom in infected participants (24.0%, 2830 of 11,785). Most participants with post-COVID-19 ME\/CFS also met RECOVER criteria for long COVID (88.7%, 471 of 531).<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Journal of Internal Medicine Background Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) may occur after infection. How often people develop ME\/CFS after SARS-CoV-2 infection is unknown. Objective To determine the incidence and prevalence of post-COVID-19 ME\/CFS among adults enrolled in the Researching COVID to Enhance Recovery (RECOVER-Adult) study. Design, Setting, and Participants RECOVER-Adult is a longitudinal observational [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[16],"tags":[],"class_list":["post-8474","post","type-post","status-publish","format-standard","hentry","category-published-research"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/8474","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/comments?post=8474"}],"version-history":[{"count":1,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/8474\/revisions"}],"predecessor-version":[{"id":8475,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/posts\/8474\/revisions\/8475"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/media?parent=8474"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/categories?post=8474"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/healthsecurity\/transmission\/wp-json\/wp\/v2\/tags?post=8474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}