Integrative Physiology & Molecular Medicine

The Integrative Physiology & Molecular Medicine (IPMM) doctoral program provides diverse research and learning experiences that emphasize cellular and molecular processes underscoring coordinated integration of organ systems within the body, typically with a view to unraveling disease mechanisms.  The interdisciplinary environment of the IPMM doctoral program, involving both basic scientists and clinician scientists, facilitates the acquisition of modern experimental techniques and development of the intellectual tools required for their effective implementation in the study of current problems in health and disease. Students in the IPMM typically pursue research projects that combine sophisticated approaches for study of cellular & molecular function with powerful integrative physiological techniques.

Research Interests

Training in IPMM is designed to optimize the ability of students to address a broad range of research problems that can be categorized into several general themes that represent contemporary strategies for understanding molecular and integrative mechanisms contributing to physiology and pathophysiology. There are no clear lines of demarcation between these categories, and interactions across thematic lines are routine and encouraged.  Although research within IPMM extends beyond the scope of the listed categories, this organization is useful for the purpose of describing the breadth of opportunities available.

Cell Transport and Signaling research examines the molecular mechanisms that regulate function at the single cell level:

Mechanisms of Cellular Injury and Fibrogenesis are being unraveled in research focusing on mechanisms of cellular injury, death, repair and regeneration in a variety of disease settings, including:

Inflammatory and autoimmune processes are the focus of studies designed to unveil mechanisms contributing to a variety of diseases, including:

Cardiovascular Function research focuses on the intracellular, neural and humoral mechanisms regulating the heart and vasculature in health and disease.

Therapeutic strategies are being developed to target key pathophysiological processes: