Tomas Helikar, PhD
My research expertise is in computational systems biology, technology development, and STEM education.
For more information on Dr. Helikar: Helikar lab webpage
Oleh Khalimonchuk, PhD
Mitochondria are highly dynamic and complex organelles responsible for cellular energy conversion, a plethora of key metabolic pathways, maintenance of ion homeostasis and programmed cell death. Perturbations of mitochondrial homeostasis and integrity result in dysfunctions that manifest in a spectrum of early to adult-onset neurological and cardiovascular disorders and are contributor to certain types of cancer, type II diabetes and neurodegeneration. Understanding the molecular bases of mitochondrial function/dysfunction is key for finding ways to combat these currently incurable disorders. Our research utilizes yeast and mammalian cell models to address the following questions:
1. Role of the protein quality control in mitochondrial homeostasis and stress response
2. Biogenesis and maintenance of the protein complexes within the inner mitochondrial membrane
For more information on Dr. Khalimonchuk: Khalimonchuk lab webpage
Limei Zhang, PhD
Owing to their versatile reactivity, transition metals are widely used as a powerful weapon by the host and bacterial pathogens during infection. Knowledge of the structure and function of metalloproteins involved in the metal homeostasis and stress response is highly desirable because of their potentials as promising targets for new antimicrobial therapies. Research in the Zhang laboratory focuses on metalloproteins in sensing and responding to redox stress. Students in the Zhang group use interdisciplinary approaches to decipher the action mechanism of these redox sensors.
For more information on Dr. Zhang: Webpage
Lindsey Crawford, PhD
Our lab studies how viruses manipulate the human immune system. Specifically, we are focused on how HCMV (a common human herpesvirus) infects and controls hematopoietic stem cells (the foundational cell for the immune system). Projects in the lab address fundamental questions about viral biology, stem cell biology, and immune system development, and students will learn to use tools and techniques from biochemistry, virology, immunology, and stem cell biology. These questions are aimed at developing a more complete picture of human immune system development, disease pathogenesis, and intrinsic mechanisms of stem cell biology.
For more information on Dr. Crawford: Webpage