Clinical Faculty Bio

GuminaRichard J. Gumina, M.D, Ph.D.,
Acting Chief for Cardiovascular Research
Associate Professor of Internal Medicine
Division of Cardiovascular Medicine
Nebraska Medicine Cardiovascular Center     

Academic Office:
982265 Nebraska Medical Center
Omaha, NE 68198-2265

Practice Locations:
Durham Outpatient Center

Hospital Appointments:
Nebraska Medicine

Board Certification:
Internal Medicine, Interventional Cardiology
Internal Medicine, Cardiovascular Medicine

9/1983-6/1998     Bachelor of Science (Biochemistry)
University of California, Davis, CA

7/1992-10/1995   Predoctoral Fellow
                          Department of Cellular Biology and Anatomy
                          Medical College of Wisconsin, Milwaukee, WI
                          Platelet Molecular Biology
                          Blood Center of Southeastern Wisconsin, Milwaukee, WI

7/1992-5/1997     Graduate School
                          Medical College of Wisconsin, Milwaukee, WI
                          Dissertation: "PECAM-1: from regulation of expression to its role in myocardial
                          ischemia-reperfusion injury." Advisor: Peter J. Newman, Ph.D.                         

8/1990-5/1997     Medical School
                          Medical College of Wisconsin, Milwaukee, WI

6/1997-6/1998     Postdoctoral Fellowship
                          Department of Pharmacology and Toxicology and the Cardiovascular Research
                          Medical College of Wisconsin, Milwaukee, WI
                          Advisor: Garrett J. Gross, Ph.D.

7/1998-6/2001     Internal Medicine Residency
                          Mayo Clinic, Rochester, MN

4/2001-3/2003     Clinician Investigator Fellow
                          Division of Cardiovascular Diseases
                          Mayo Clinic and Foundation, Rochester, MN

7/2001-6/2005    Cardiovascular Diseases Fellowship
                          Mayo Clinic, Rochester, MN

7/2005-6/2006    Interventional Cardiology Fellowship
                         Mayo Clinic, Rochester, MN

Biographical Sketch:

Clinical Expertise:

Research Expertise:

Selected Publications: 

  1. Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R,  He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE Jr, Su YR, Absi TS, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS,  Gumina RJ. Kcnj11 is necessary to modulate the nitro-oxidative stress of ischemia-reperfusion injury: implications for human ischemic cardiomyopathy (accepted for publication Circulation Heart Failure).
  2. Smith SB, Xu Z, Novitskaya T, Zhang B, Chepurko E, Pu XA, Wheeler DG, Ziolo M, Gumina RJ. Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice. Life Sci. 2016 Oct 15. pii: S0024-3205(16)30607-5. doi: 10.1016/j.lfs.2016.10.016. [Epub ahead of print].
  3. Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice. Covarrubias R, Chepurko E, Reynolds A, Huttinger ZM, Huttinger R, Stanfill K, Wheeler DG, Novitskaya T, Robson SC, Dwyer KM, Cowan PJ, Gumina RJ. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1809-20. doi: 10.1161/ATVBAHA.116.307374. Epub 2016 Jul 14.
  4. Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK. The BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Circ Res. 2016 Jul 22;119(3):434-49. doi: 10.1161/CIRCRESAHA.116.308700.
  5. Stephenson MK, Lenihan S, Roman Covarrubias R, Huttinger RM, Gumina RJ, Sawyer DB, Galindo Sanning electron microscopy of macerated tissue to visualize the extracellular matrix. J Vis Exp. 2016 Jun 14;(112). doi: 10.3791/54005.
  6. Novitskaya T, Chepurko E, Covarrubias R, Novitskiy S, Ryzhov SV, Feoktistov I, Gumina RJ. Extracellular nucleotide regulation and signaling in cardiac fibrosis. J Mol Cell Cardiol. 2016 Feb 16;93:47-56.
  7. Ryzhov S, Sung BH, Zhang Q, Weaver A, Gumina RJ, Biaggioni I, Feoktistov I. Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation. Purinergic Signal. 2014 Sep;10(3):477-86.
  8. Boudoulas KD, Ravi Y, Garcia D, Saini U, Sofowora GG, Gumina RJ, Sai-Sudhakar CB . Type of Valvular Heart Disease Requiring Surgery in the 21st Century: Mortality and Length-of-Stay Related to Surgery. Open Cardiovasc Med J. 2013 Sep 4;7:104-9.
  9. Saini U, Gumina RJ, Wolfe B, Kuppusamy ML, Kuppusamy P, Boudoulas KD. Preconditioning mesenchymal stem cells with caspase inhibition and hyperoxia prior to hypoxia exposure decreases apoptosis and increases cell survival. Journal of Cellular Biochemistry. 2013 Nov;114(11):2612-23.
  10. Boudoulas KD, Pederzolli A, Saini U, Gumina RJ, Mazzaferri EL Jr, Davis MB, Bush CA, Capers Q IV, Magorien R, Pompili VJ. Comparison of Impella and Intra-Aortic Balloon Pump in High-Risk Percutaneous Coronary Intervention: Vascular Complications and Incidence of Bleeding. Acute Cardiac Care. 2012 Dec;14(4): ):120-4.