Clinical Faculty Bio

Yiannis Chatzizisis, M.D., Ph.D.                                                                                                                                                                                                                                                                                                     
Associate ProfessorYiannis Chatzizisis, MD
Division of Cardiovascular Medicine

Academic office:
Department of Internal Medicine
982265 Nebraska Medical Center
Omaha, NE 68198-2265

Practice Locations:
Omaha, Nebraska
Durham Outpatient Center
For An Appointment Call (402)559-8888
Toll Free 1-800-97-HEART (1-800-974-3278)

Hospital Appointments:
Nebraska Medicine
Board Certification:
Cardiovascular Medicine


1994 - 2000 MD, Medicine, Aristotle University Medical School, Thessaloniki, Greece

2002 - 2004 MSc, Medical Research and Technology, Aristotle University Medical School, Thessaloniki, Greece

2004 - 2009 PhD, Medicine, Aristotle University Medical School, Thessaloniki, Greece

Clinical Interests:  

Research Interests:

Research Support:


Completed Research Support 



Antoniadis AP, Papafaklis MI, Takahashi S, Shishido K, Andreou I, Chatzizisis YS, Tsuda M, Mizuno S, Makita Y, Domei T, Ikemoto T, Coskun AU, Honye J, Nakamura S, Saito S, Edelman ER, Feldman CL, Stone PH. Arterial remodeling and endothelial shear stress exhibit significant longitudinal heterogeneity along the length of coronary plaques. JACC Cardiovasc. Imaging 2016;9:1007-9.   PMID:27491487

Chatzizisis YS, Toutouzas K, Giannopoulos AA, Riga M, Antoniadis AP, Fujinom Y, Mitsouras D, Koutkias VG, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Chouvarda I, Kompatsiaris I, Nakamura S, Rybicki FJ, Maglaveras N, Tousoulis D, Giannoglou GD.  Association of global and local low endothelial shear stress with high-risk plague using intracoronary 3D optical coherence tomography: introductions of ‘shear stress score’. Eur Heart J Cardiovasc Imaging. 2016 [epub ahead of print]   PMID: 27461211

Tsigkas N, Kidambi S, Tawakol A, Chatzizisis YS. Drug-loaded particles: “Trojan horses” in the therapy of atherosclerosis. Atherosclerosis 2016;251:528-30.  PMID: 27401604

Giannopoulos AA, Chatzizisis YS, Murovich-Horvat P,  Antoniadis AP, Hoffman U, Steigner ML, Rybicki FJ, Mitsouras D. Quantifying the effect of side branches  in endothelial shear stress estimates. Atherosclerosis 2016;251:213-8   PMID: 27372207

Carreras ET, Chatzizisis YC, Mauri L, MacRae C. Acute coronary syndrome in a 52 year old women with scleroderma. Circulation 2016;133:2576-82   PMID: 27297349

Giannopoulos AA, Giannoglou GD, Chatzizisis YS. Refractory angina: new drugs on the block. Expert Rev Cardiovasc Ther. 2016;14:881-3    PMID:27269473

Giannopoulos AA, Antoniadis AP, Croce K, Chatzizisis YS. Erosion of Thin-Cap fibroatheroma in an area of low endothelial shear stress: Anatomy and local hemodynamic environment dictate outcomes. JACC Cardiovasc Interv. 2016;9:e77-8

Giannoupoulos AA, Giannoglou GD, Chatzizisis YS.  Pharmacological approaches of refractory angina. Pharmacol Ther. 2016;163:118-31  PMID: 27013345

Gitsioudis G, Chatzizisis YS, Wolf P, Missiou A, Antoniadis AP, Mitsouras D, Bartling S, Arica Z, Stuber M, Rybicki FJ, Nunninger M, Erbel C, Libby P, Giannoglou GD, Katus HA. Korosoglou G. Combined non-invasive assessment of endothelial shear stress and molecular imaging of inflammation for the prediction of inflamed plaque in hyperlipidaemic rabbit aortas. Eur Heart J Cardiovasc Imaging 2017;18:19-30 PMID: 27013245

Giannoglou GD, Giannopoulos AA, Chatzizisis YS. Lowering Heart Rate Post Revascularization: Angina and Quality of Life Improvement. Angiology. 2017;68:5-7  PMID: 26882925

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