Yiannis S. Chatzizisis, MD, PhD, FACC, FAHA, FESC
Associate Professor of Internal Medicine
Associate Professor of Cellular and Integrative Physiology
Division of Cardiovascular Medicine
Attending Cardiologist
Cardiac Catheterizations Laboratories and Cardiac CT/MRI Program
Director of Heart and Vascular Unit
Director of Cardiovascular Biology and Biomechanics 
Medical Director of Cardiovascular Telemetry 

Academic office:
Department of Internal Medicine
982265 Nebraska Medical Center
Omaha, NE 68198-2265                                                                                                                     

Practice Locations:
Durham Outpatient Center
4400 Emile Street
Omaha, NE 68105
For An Appointment Call (402)559-8888
Toll Free 1-800-97-HEART (1-800-974-3278)

Hospital Appointments:
Nebraska Medicine
Nebraska Medicine - Bellevue

Board Certification:
Internal Medicine
Cardiovascular Medicine
Interventional Cardiology
Cardiac CT
Echocardiography
Nuclear Cardiology  

Education and Training:
1994-2000 Aristotle University Medical School,Thessaloniki, Greece
MD

2002-2004 Aristotle University Medical School, Thessaloniki, Greece
MSc, Medical Research and Technology

2004-2009 Aristotle University Medical School, Thessaloniki, Greece
PhD

2005-2008 Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School,
Boston, Massachusetts
Post-Doctoral Research Fellowship in Cardiovascular Medicine

2006-2008 Harvard-MIT Division of Health Science & Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts
Post-doctoral Research Fellowship in Cardiovascular Medicine

2012-2014 Clinical Fellowship, Advanced Non-Invasive Cardiovascular Imaging
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School,
Boston, Massachusetts

2014-2015 Clinical Fellowship, Interventional Cardiology
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School
Boston, Massachusetts

Clinical Expertise:
Interventional cardiology (high-risk protected PCI, bifurcation PCI)
Advanced non-invasive cardiovascular imaging (Cardiac CT, MRI, nuclear cardiology and echocardiography)

Research Expertise:
At UNMC, Dr. Chatzizisis directs the Cardiovascular Biology and Biomechanics Laboratory, a research venue where MDs, vascular biologists and biomedical engineers perform basic, translational and clinical research in atherosclerosis and stents.

For more information on the Cardiovascular Biology and Biomechanics Laboratory: https://unmc.edu/intmed/divisions/cardiology/research/cbbl/index.html

Clnical Trials:

• Safe STEMI for Seniors (Study of Access Site for Enhancing PCI in STEMI for Seniors; NCT02939976; Site PI): Multicenter, randomized, open-label, unblinded, active and historical-controlled trial in which approximately 875 seniors undergoing urgent PCI from approximately 70 centers will be enrolled. For DES (Drug Eluting Stent) eligible patients without randomization exclusion criteria and with multi-vessel disease identified during initial angiogram will be randomized by site in a ratio of 1:1 to IRA-only revascularization or iFR-guided complete revascularization. After randomization, subjects with stable TIMI-3 flow established in the IRA using the protocol specified treatment will proceed with the randomized procedure.
• Flow ISR (Effect of Local Biomechanical Factors on Bifurcation Stent Restenosis and Thrombosis; PI): Multi-center, prospective, open-label study that aims to: 

• • Test the hypothesis that local hemodynamic environment immediately post-intervention can predict anatomical stent restenosis and adverse outcomes,
  • Compare the effect of two major post-dilatation techniques (i.e. proximal optimization technique vs. kissing balloon inflation) on the local hemodynamic environment post-intervention and on the subsequent stent restenosis at follow-up
  • Validate a patient-specific computational simulation strategy of bifurcation stenting.

 Publications:

1. Baibhav B, Gedela M, Moulton M, Pavlides G, Pompili V, Rab T, Dangas G, Bhatt DL, Siddique A, Chatzizisis YS. Role of Invasive Functional Assessment in Surgical Revascularization of Coronary Artery Disease. Circulation. 2018;137(16):1731-1739. 

2. Burzotta F, Lassen JF, Banning AP, Lefèvre T, Hildick-Smith D, Chieffo A, Darremont O, Pan M, Chatzizisis YS, Albiero R, Louvard Y, Stankovic G. Percutaneous coronary intervention in left main coronary artery disease: the 13^th consensus document from the European Bifurcation Club. EuroIntervention. 2018;14(1):112-120. 

3. Chatzizisis YS, Toutouzas K, Giannopoulos AA, Riga M, Antoniadis AP, Fujinom Y, Mitsouras D, Koutkias VG, Cheimariotis G, Doulaverakis C, Tsampoulatidis I, Chouvarda I, Kompatsiaris I, Nakamura S, Rybicki FJ, Maglaveras N, Tousoulis D, Giannoglou GD. Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of 'shear stress score'. Eur Heart J Cardiovasc Imaging. 2017;18(8):888-897. 

4. Gitsioudis G, Chatzizisis YS, Wolf P, Missiou A, Antoniadis AP, Mitsouras D, Bartling S, Arica Z, Stuber M, Rybicki FJ, Nunninger M, Erbel C, Libby P, Giannoglou GD, Katus HA, Korosoglou G. Combined non-invasive assessment of endothelial shear stress and molecular imaging of inflammation for the prediction of inflamed plaque in hyperlipidaemic rabbit aortas. Eur Heart J Cardiovasc Imaging. 2017;18(1):19-30. 

5. Antoniadis AP, Mortier P, Kassab G, Dubini G, Foin N, Murasato Y, Giannopoulos AA, Tu S, Iwasaki K, Hikichi Y, Migliavacca F, Chiastra C, Wentzel JJ, Gijsen F, Reiber JH, Barlis P, Serruys PW, Bhatt DL, Stankovic G, Edelman ER, Giannoglou GD, Louvard Y, Chatzizisis YS. Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation. JACC Cardiovasc Interv. 2015;8(10):1281-96. 

6. Koskinas KC, Chatzizisis YS, Papafaklis MI, Coskun AU, Baker AB, Jarolim P, Antoniadis A, Edelman ER, Stone PH, Feldman CL. Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs. Int J Cardiol. 2013;169(6):394-401. 

7. Koskinas KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH. Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1494-504. 

8. Koskinas KC, Chatzizisis YS, Antoniadis AP, Giannoglou GD. Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation. J Am Coll Cardiol. 2012;59(15):1337-49. 

9. Wentzel JJ, Chatzizisis YS, Gijsen FJ, Giannoglou GD, Feldman CL, Stone PH. Endothelial shear stress in the evolution of coronary atherosclerotic plaque and vascular remodelling: current understanding and remaining questions. Cardiovasc Res. 2012;96(2):234-43. 

10. Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011;123(6):621-30. 

11. Koskinas KC, Feldman CL, Chatzizisis YS, Coskun AU, Jonas M, Maynard C, Baker AB, Papafaklis MI, Edelman ER, Stone PH. Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound study. Circulation. 2010;121(19):2092-101. 

12. Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk coronary atherosclerotic plaques. Atherosclerosis. 2009;203(2):387-94. 

13. Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation. 2008;117(8):993-1002. 

14. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49(25):2379-93.

 For complete list of publications