Three-dimensional co-culture as an in-vitro model of atherosclerosis study (#17056P1) 


To facilitate a systematic and cheap experimental approach on comprehending and reversing the atherosclerotic process, we developed a novel 3D co-culture model of atherosclerosis. In this model, endothelial cells, smooth muscle cells and monocytes are cultured and interact together simulating in an accurate way the vascular milieu of atherosclerosis.

Stitching device for trans-catheter vascular anastomosis (#18040P) 


The invention is a catheter head that consists of multiple suturing units that are placed next to each other in a circumferential manner. Each suturing unit consists of two needles with a U-shaped wire hanging in between. A vascular graft will be mounted on the suturing head before-hand. The catheter with the suturing head will be introduced into the vessel using standard endovascular techniques, and a hole into the vascular walls will be made to create the communication between the two lumens. 

Time-varying quantification of capacitive and resistive arterial blood flow (PCT/US19/19110)


Technology that can be used for continuous measurements of blood pressure an arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patient's vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessement of the control of vascular resistance and capacitance in real time.

Catheter for atraumatic fluid delivery (WO2109/032473)


In embodiments, the catheter includes a catheter shaft with a guidewire lumen disposed within the catheter shaft and an infusion lumen at least partially defined by the catheter shaft. The infusion lumen may at least partially surround the guidewire lumen. The catheter shaft includes a pluratily of pores extending through an outer surface of the catheter shaft to the infusion lumen. The plurality of pores are disposed near a distal end of the catheter shaft and are configured to radially dispense a fluid from the infusion lumen. A catheter system as well as a method for atraumatic fluid delivery of fluid to a target within a biological lumen are also disclosed. 

Computational Simulations Platform for Interventional Procedures Planning (17/076,213 and PCT/US20/57304)


In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; generating a mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; assigning material properties to the 3D reconstructed surface of the vessel lumen; importing design and material properties of stents and balloons; generating a mesh of a stent and balloon; positioning the meshed stent and balloon within the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.