Studies have shown calcium channel blockers significantly reducing ischemia and supraventricular tachycardia events.
Calcium channel blockers were associated with trends toward reduced death and MI.
Calcium channel blockers significantly reduced death/MI The majority of these benefits were attributable to diltiazem. Dihydropyridines and verapamil did not decrease the incidence of myocardial ischemia, although verapamil decreased the incidence of supraventricular tachycardia. A large-scale trial is needed to define the value of these agents.
Of note, calcium blockers with substantial negative inotropic effects, such as diltiazem and verapamil, may precipitate or worsen HF in patients with depressed EF and clinical HF.
Currently the use of CCB in perioperative medicine is not standardized but has shown to decrease cardiac mortality in some studies. Stay tuned.