Calcium Channel Blockers: Stay Tuned

  • Studies have shown calcium channel blockers significantly reducing ischemia and supraventricular tachycardia events.
  • Calcium channel blockers were associated with trends toward reduced death and MI.
  • Calcium channel blockers significantly reduced death/MI The majority of these benefits were attributable to diltiazem. Dihydropyridines and verapamil did not decrease the incidence of myocardial ischemia, although verapamil decreased the incidence of supraventricular tachycardia. A large-scale trial is needed to define the value of these agents.
  • Of note, calcium blockers with substantial negative inotropic effects, such as diltiazem and verapamil, may precipitate or worsen HF in patients with depressed EF and clinical HF.
  • Currently the use of CCB in perioperative medicine is not standardized but has shown to decrease cardiac mortality in some studies. Stay tuned.