Terrence M. Donohue, Ph.D.

Terrence Donohue, Ph.D.Professor, Internal Medicine, Gastroenterology & Hepatology

Academic office:
Room R327A, Omaha VA Medical Center
4101 Woolworth Ave
Omaha, NE 68105 Mail Stop, 151

 Oak Ridge National Laboratory, Oak Ridge, TN Post Doc, 1981
University of Nebraska Medical Center, PhD, 1978
Marquette University, MS, 1972 University of St. Thomas, BA, 1969

Areas of Interest
Role of autophagy in the pathogenesis of alcohol-induced liver disease; We seek to determine how autophagy (“self eating”, the lysosomal degradation of the cell’s own contents, affects the severity of liver cell injury after chronic alcohol exposure. Our findings have revealed that ethanol oxidation by the liver disrupts autophagy, leading to hepatic protein and fat accumulation in the hepatocyte, which is the “first hit” in the pathogenesis of alcohol-induced liver injury. Sustained disruption of autophagy by heavy drinking can lead to more severe hepatic injury, including hepatitis, fibrosis, cirrhosis, and liver cancer.

Selected Publications
Thomes PG, Ehlers RA, Trambly CS, Clemens DL, Fox HS, Tuma DJ, Donohue, TM Jr.. Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells. Autophagy 9: 63-73 (2013) PMID 23090141

Thomes, PG, Trambly, CS, Fox, HS, Tuma, DJ, Donohue, TM. Acute and chronic ethanol administration differentially modulate hepatic autophagy and transcription factor EB. Alcoholism: Clin Exp Res 39: 2354- 2363. 2015. PMID 26556759

For more publications