Murali Ganesan, Ph.D.

Murali Ganesan, Ph.D.Assistant Professor, Internal Medicine, Gastroenterology & Hepatology

Academic office:
R207, Omaha VA Medical Center
4101 Woolworth Ave
Omaha, NE 68105

Education:
University of Madras, Ph.D, 2009
University of Madras, M.Sc, 2003
University of Madras, B.Sc, 2001

Areas of Interest
I have been working in the field of alcoholic liver injury, with special emphasis on “second hits” such as Hepatitis B Virus, Hepatitis C Virus and HIV. My current NIH-K01 grant focus is how alcohol suppresses the HBV peptide-MHC class I presentation on hepatocytes.

Selected Publications
Ganesan M, Krutik VM, Makarov E, Mathews S, Kharbanda KK, Poluektova LI, Casey CA, Osna NA. Acetaldehyde Suppresses the Display of HBV-MHC class I Complexes on HBV-Expressing Hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2019 May 29. doi: 10.1152/ajpgi.00064.2019. [Epub ahead of print] PubMed PMID: 31141391.

Ganesan M, Poluektova LY, Kharbanda KK, Osna NA. Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression. World J Gastroenterol. 2019 Jan 28;25(4):398-410. doi: 10.3748/wjg.v25.i4.398. Review. PubMed PMID: 30700937; PubMed Central PMCID: PMC6350175.

Ganesan M, Dagur RS, Makarov E, Poluektova LI, Kidambi S, Osna NA. Matrix stiffness regulate apoptotic cell death in HIV-HCV co-infected hepatocytes: Importance for liver fibrosis progression. Biochem Biophys Res Commun. 2018 Jun 7;500(3):717-722. doi: 10.1016/j.bbrc.2018.04.142. Epub 2018 Apr 22. PubMed PMID: 29679566.

Ganesan M, Tikhanovich I, Vangimalla SS, Dagur RS, Wang W, Poluektova LI, Sun Y, Mercer DF, Tuma D, Weinman SA, Kharbanda KK, Osna NA. Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism. Cell Mol Gastroenterol Hepatol. 2017 Oct 16;5(2):101-112. doi: 10.1016/j.jcmgh.2017.10.004. eCollection 2018. PubMed PMID: 29693039; PubMed Central PMCID: PMC5904050.

Ganesan M, Poluektova LY, Tuma DJ, Kharbanda KK, Osna NA. Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18. Alcohol Clin Exp Res. 2016 Nov;40(11):2329-2338. doi: 10.1111/acer.13226. Epub 2016 Sep 26. PubMed PMID: 27716962.

Ganesan M, Natarajan SK, Zhang J, Mott JL, Poluektova LI, McVicker BL, Kharbanda KK, Tuma DJ, Osna NA. Role of apoptotic hepatocytes in HCV dissemination: regulation by acetaldehyde. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G930-40. doi: 10.1152/ajpgi.00021.2016. Epub 2016 Apr 7. PubMed PMID: 27056722.3.

Ganesan M, Zhang J, Bronich T, Poluektova LI, Donohue TM Jr, Tuma DJ, Kharbanda KK, Osna NA. Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells. Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G566-77. doi: 10.1152/ajpgi.00183.2015. Epub 2015 Aug 6. PubMed PMID: 26251470.

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