Natalia Osna, Ph.D.

Natalia Osna, Ph.D.Associate Professor, Internal Medicine, Gastroenterology & Hepatology

Academic office:
Omaha VA Medical Center
4101 Woolworth Ave
Omaha, NE 68105

Education:
Latvian Medical Academy (P. Stradina University), Riga, Latvia, Ph.D, 1984
Latvian Medical Academy (P. Stradina University), Riga, Latvia, MD, 1978

Areas of Interest
Role of inflammation, innate immunity, apoptosis, proteasome dysfunctions and extracellular vesicles in the mechanisms of liver disease development; alcohol-induced liver injury; HIV-triggered liver injury; HCV, HBV and HIV-co-infections; second hits (co-infections, alcohol) in potentiation of HIV-induced liver and fibrosis progression.

Selected Publications

Osna, NA, White, RL, Krutik, VM, Wang, T, Weinman, SA, Donohue, TM. Proteasome Activation by Hepatitis C Core Protein is Reversed by Ethanol-Induced Oxidative Stress. Gastroenterology 2008; 134:2144-2152.

Osna NA, White RL, Thiele G, Donohue TM. Ethanol Metabolism Alters Major Histocompatibility Complex Class I-Restricted Antigen Presentation In Liver Cells. Hepatology, 2009; 49:1308-1315.

Murali Ganesan, Raghubendra Singh Dagur, Edward Makarov, Larisa I. Poluektova, Srivatsan Kidambi, Natalia A. Osna. Matrix Stiffness regulate apoptotic cell death in HIV-HCV co-infected hepatocytes: importance for liver fibrosis progression. Biochemical and Biophysical Research Communications, 2018, 1-6.

Murali Ganesan, Larisa Y. Poluektova, Chijioke Enweluzo, Kusum K. Kharbanda, Natalia A. Osna. HCV-infected apoptotic hepatocytes program macrophages and hepatic stellate cells for liver inflammation and fibrosis development: role of ethanol as a second hit. Biomolecules, 2018, 8, 113;

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