Karuna Rasineni, Ph.D.

RasineniAssistant Professor, Internal Medicine, Gastroenterology & Hepatology

Academic office:
Omaha VA Medical Center
4101 Woolworth Ave
Omaha, NE 68105

Education:
Sri Krishnadevaraya University, India, Ph.D, 2009
Sri Krishnadevaraya University, India, M.phil, 2006
Sri Krishnadevaraya University, India, MSC, 2003
Sri Krishnadevaraya University, India, BSC, 2001

Areas of Interest
I have been working in the field of alcoholic and non-alcoholic liver disease, with special interest in the role of ghrelin hormone in development of fatty liver. I am also interested in a role for ghrelin in impairing adipose tissue metabolism in the development of hepatic steatosis during the pathogenesis of both alcohol and/or non-alcoholic fatty liver disease. I have a broad background in endocrinology and metabolic diseases with specific training and expertise. These studies are part of an overall goal to investigate organ interactions particularly stomach-pancreas-liver cross talks in the development of fatty liver disease. Our studies are important since a proper understanding of the mechanisms involved in ghrelin mediated dysregulation of adipose metabolism would provide valuable information for designing effective therapeutic strategies against fatty liver disease development.

Selected Publications
Karuna Rasineni, Paul G. Thomes, Jacy L. Kubik, Edward N. Harris, Kusum K. Kharbanda, and Carol A. Casey. Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis. American Journal of Physiology-Gastrointestinal and Liver Physiology. *Corresponding author. https://doi.org/10.1152/ajpgi.00334. 2018.

Paul G. Thomes, Karuna Rasineni, Li Yang, Jacy L. Kubik, Terrence M. Donohue, Mark A. McNiven, and Carol A. Casey. Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism. American Journal of Physiology-Gastrointestinal and Liver Physiology. doi: 10.1152/ajpgi.00376. 2018

Rasineni, K,
Penrice, D, Natarajan, S, McNiven, M, McVicker, B, Kharbanda, K, Casey, C, Harris, E. Alcoholic versus non-alcoholic fatty liver: Differences in function and content of proteins involved in vesicle trafficking and receptor-mediated endocytosis. BMC Gastroenterology, 2016, 16:27, DOI:10.1186/s12876-016-0433-4

Rasineni, K,
Donohue, T., Thomes, P., Yang, L, Tuma D, McNiven, M, and Casey, C. Ethanol-induced steatosis involves impairment of lipophagy, associated with reduced Dynamin 2 activity. Hepatology Communications, DOI.1002/hep4.1063 2017

Ryan J. Schulze*, Karuna Rasineni*, Shaun G. Weller, Micah B. Schott, Barbara Schroeder, Carol A. Casey, and Mark A. McNiven. Ethanol exposure inhibits hepatocyte lipophagy by inactivating the small guanosine triphosphatase Rab7. Hepatology Communications, 2017; 1: 140-152. * Equal authors

Schott, M*, Rasineni, K, Weller, S, 1, Schulze R, Casey C, and McNiven, M. Hepatocellular lipolysis is induced by β-adrenergic stimulation and inhibited by ethanol exposure. Journal of Biological Chemistry, 292(28): DOI: 10.1074/jbc.M117.777748

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