Paul Thomes, Ph.D.

Thomes.jpgAssistant Professor, Internal Medicine, Gastroenterology & Hepatology

Academic office:
Omaha VA Medical Center
4101 Woolworth Ave
Omaha, NE 68105

Education:
University of Nebraska Medical Center, Post-doctoral, 2012
University of Madras, India, PhD, 2008
University of Madras, India, B.Sc, 1999

Areas of Interest
The primary focus of my work is to understand the basic cellular and molecular mechanisms behind alcohol-induced organ dysfunction and loss of homeostasis. My specific interest is to understand the functional role of macroautophagy (autophagy), a major macromolecule degrading pathway and its selective forms (lipophagy, mitophagy), in the pathophysiology of alcohol-Induced tissue Injury (AITI). The long-term goal of my research is to identify underlying biological mechanisms, therapeutic targets and strategies to prevent, treat or alleviate AITI.

Selected Publications
Yang L, Yang C, Thomes PG, Kharbanda KK, Casey CA, McNiven MA, Donohue TM Jr. Lipophagy and Alcohol-Induced Fatty Liver. Front Pharmacol. 2019;10:495. PMID: 31143122

Thomes PG, Rasineni K, Yang L, Donohue TM Jr, Kubik JL, McNiven MA, Casey CA. Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism. Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G509-G518. PMID: 30714813

Thomes PG, Benbow JH, Brandon-Warner E, Thompson KJ, Jacobs C, Donohue TM Jr, Schrum LW. Dietary fructose augments ethanol-induced liver pathology. J Nutr Biochem. 2017 May;43:141-150. PMID: 28315617

Thomes PG, Brandon-Warner E, Li T, Donohue TM Jr, Schrum LW. Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype. Int J Biochem Cell Biol. 2016 Dec;81(Pt A):137-147. PMID: 27840152

Thomes PG, Trambly CS, Fox HS, Tuma DJ, Donohue TM Jr. Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB. Alcohol Clin Exp Res. 2015 Dec;39(12):2354-63. PMID: 26556759

Thomes PG, Osna NA, Bligh SM, Tuma DJ, Kharbanda KK. Role of defective methylation reactions in ethanol-induced dysregulation of intestinal barrier integrity. Biochem Pharmacol. 2015 Jul 1;96(1):30-8. PMID: 25931143.

Donohue TM Jr, Thomes PG. Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity. Redox Biol. 2014;3:29-39. PMID: 25462063

Thomes PG, Ehlers RA, Trambly CS, Clemens DL, Fox HS, Tuma DJ, Donohue TM. Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells. Autophagy. 2013 Jan;9(1):63-73. PMID: 23090141

Dolganiuc A, Thomes PG, Ding WX, Lemasters JJ, Donohue TM Jr. Autophagy in alcohol-induced liver diseases. Alcohol Clin Exp Res. 2012 Aug;36(8):1301-8. PMID: 22551004

Thomes PG, Trambly CS, Thiele GM, Duryee MJ, Fox HS, Haorah J, Donohue TM Jr. Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment. Biochem Biophys Res Commun. 2012 Jan 6;417(1):262-7. PMID: 22142844

 

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