University of Nebraska Medical Center

Paul Thomes, PhD

Assistant Professor, Division of Gastroenterology and Hepatology


Dr. Thomes' primary focus is to understand the basic cellular and molecular mechanisms behind alcohol-induced organ dysfunction and loss of homeostasis. His specific interest is to understand the functional role of macroautophagy (autophagy), a major macromolecule degrading pathway and its selective forms (lipophagy, mitophagy), in the pathophysiology of alcohol-Induced tissue Injury (AITI). The long-term goal of his research is to identify underlying biological mechanisms, therapeutic targets and strategies to prevent, treat or alleviate AITI.


Active Grant Support


  • "Altered Lipid Droplet Trafficking Role in Alcoholic Fatty Liver Disease" Co-Investigator (Casey), DHHS/NIH/NIAAA
  • "Autophagy-mediated mucin degradation is necessary for resolution of mucous metaplasia" Co-Investigator (Dickinson), DHHS/NIH/NHLBI
  • "IPA for Paul Thomes" Other (Casey), VA Medical Center - Omaha


  • "Alcohol Center Of Research-Nebraska (ACORN)" Co-Investigator (Casey), DHHS/NIH/NIAAA
  • "Role of Intestinal Autophagy in the Pathogenesis of Alcohol Associated Liver Injury" Principal Investigator, DHHS/NIH/NIAAA
  • "Role of Lysosome Damage in ALD Pathogenesis" Principal Investigator, DHHS/NIH/NIAAA
  • BS: University of Madras, Chennai, Tamil Nadu, India, 1999
  • PhD: University of Madras, Chennai, Tamil Nadu, India, 2008
  • Postdoctoral Training: University of Nebraska Medical Center, 2012