Warren G. Sanger Human Genetics Laboratory
Munroe-Meyer Institute
985440 Nebraska Medical Center
Omaha, NE 68198-5440
Phone: 402-559-5229
Email
Professional Summary
Bhavana Dave, PhD, FACMG, is a Professor of Pathology/Microbiology, Pediatrics, Munroe-Meyer Institute, and Genetics, Cell Biology and Anatomy at the University of Nebraska Medical Center. Dr. Dave is director of the Warren G. Sanger Human Genetics Laboratory at Nebraska Medicine. Dr. Dave is board certified in Clinical Cytogenetics by the American Board of Medical Genetics (ABMG) and she is a Fellow of American College of Medical Genetics (ACMG). Dr. Dave has been involved in patient care by providing clinical cytogenetic and molecular genetic services utilizing cutting edge diagnostic tests including fluorescence in situ hybridization (FISH), array-based comparative genomic hybridization (aCGH), and next generation sequencing (NGS). Dr. Dave serves as a reviewer and is on the editorial board of Medical Genetics and Cancer Biology related journals.
Dr. Dave’s research involves in-depth genetic characterization of hematologic malignancies and delineating the basic mechanisms of the genetic abnormalities that allow us to better comprehend the consequences of genetic changes and eventually leads to better disease management. Dr. Dave is actively involved in translational research which expands our understanding of genetic diagnosis impacting the prognosis and management of a variety of diseases including cancer, developmental disorders, and prenatal conditions.
Education
FACMG, Fellow of American College of Medical Genetics (Clinical Cytogenetics)
PhD, Maharaja Sayajirao Gujarat University, Baroda, Gujarat, India
BS, MS, Gujarat University, Ahmedabad, India
Courses Taught
UNMC, PEDS 911 - Human Genetics and Cytogenetics Principles
UNMC, PEDS 912 - Human Cytogenetics Laboratory
UNMC, GCBA 912 – Modern Approaches in Cell Biology and Molecular Genetics
Training Director – ABMGG accredited Clinical Cytogenetics Fellowship program
Human Cytogenetics – Lectures and Case Reviews in Elective Rotations for Pathology, Pediatrics, and Internal Medicine Residents
Research Interests and Projects
- Breast cancer, cell cycle and the role of ADA3
- Case Control study of Pesticides and t(14;18) Lymphoma
- Categorization of genetic changes in pediatric hematologic malignancies
- Chromosome 1p36 in angiogenesis and progression of Non Hodgkin Lymphoma
- Chronic Lymphocytic Leukemia and genetic alterations of IGH@
- Cytogenetic and molecular cytogenetic investigations of multiple animal and plant species
- Defining molecular subtypes of lymphoma for relevance to survival, etiology, and diagnosis
- Epigenetic effects of Biotin on activation of endogenous retroviral sequences
- Genetic Abnormalities in Follicular and Transformed Follicular Lymphoma
- Genetic Pathways in the Evolution of Follicular Lymphoma
- Genetics of Hodgkin’s disease
- Investigating distinct genetic signatures of pediatric and adult Myelodysplastic syndromes
- Lymphoma Defined Cytogenetically for Epidemiologic Study
- Molecular Genetics of NHL: add(1)(p36) and add(14)(q32)
- Molecular Signatures to Improve Diagnosis and Outcome Prediction in NHL
- Preclinical targeting of TP73 in Mantle Cell Lymphoma and Diffuse Large B-Cell Lymphoma therapy
- Role of TP73 in Non-Hodgkin Lymphoma progression
- Secondary genetic abnormalities in Anaplastic Large Cell Lymphoma: detection and role in disease progression
Publications from PubMed
Professional Affiliations
- American Association for Cancer Research
- American Society of Human Genetics
- American College of Medical Genetics
- Association of Genetic Technologists
- Cancer Genomics Consortium (CGC)
- Indian Association for Cancer Research
- Indian Society of Cell Biology