Microarray

Test description

The current Cancer Microarray is a high density single nucleotide polymorphism (SNP) platform designed to interrogate the whole genome at resolution much higher than is possible using traditional karyotyping or fluorescence in situ hybridization (FISH) methodologies. Our High Density SNP array contains a total of 2.6 million markers distributed throughout the genome for the detection of both genomic dosage anomalies (deletions and duplications) and regions of homozygosity (ROH; regions lacking typical amounts of genetic variation). This marker density provides a global resolution of 10 Kb to 20 Kb for copy number changes and 5 Mb resolution for ROH. This microarray is designed to identify two types of genetic changes associated with neoplasm: copy number changes associated with chromosomal deletions and duplications and copy neutral loss of heterozygosity (LOH) associated with loss of genetic variation in the absence of a net loss of genetic material.  Detection of LOH is particularly useful in regions of the genome that contain oncogenes and tumor suppressor genes.


Test details and complementary testing

Advantages

Limitations