Indications for Testing

Male Infertility Panel

Genetic testing should be considered for men who exhibit non-obstructive spermatogenic failure (azoospermia or oligospermia).1 Literature suggests 7% of infertile men have a structural or numerical chromosome anomaly.2 Specifically, chromosome abnormalities are found in 3-5% of men with oligospermia, 10-19% of men with non-obstructive azoospermia, and less than 1% of men with normal sperm count.2,3 Although most often phenotypically normal, an additional 10% of men with azoospermia and severe oligospermia harbor Y chromosome microdeletions.2,4 Additional indications for testing include small testes or cryptorchidism and otherwise unexplained male factor infertility.

  1. According to the Male Infertility Best Practice Policy Committee of the American Urological Association and the Practice Committee of the American Society for Reproductive Medicine.
  2. Male Infertility In: Sabanegh, E, Agarwal, A, Campbell-Walsh Urology. 10th ed. New York, NY: Elsevier Health Sciences; 2011: 616-647.
  3. Hotaling JM. Genetics of Male Infertility. Urol Clin N Am. 2014, 41(1): 1-17.
  4. Stahl PJ, Masson P, Mielnik A, Marean MB, Schlegel PN, Paduch DA. A decade of experience emphasizes that testing for Y microdeletions is essential in American men with azoospermia and severe oligozoospermia. Fertility and Sterility. 2010, 94(5): 1753-1756.