Male Infertility Panel
Genetic testing should be considered for men who exhibit non-obstructive spermatogenic failure (azoospermia or oligospermia).1 Literature suggests 7% of infertile men have a structural or numerical chromosome anomaly.2 Specifically, chromosome abnormalities are found in 3-5% of men with oligospermia, 10-19% of men with non-obstructive azoospermia, and less than 1% of men with normal sperm count.2,3 Although most often phenotypically normal, an additional 10% of men with azoospermia and severe oligospermia harbor Y chromosome microdeletions.2,4 Additional indications for testing include small testes or cryptorchidism and otherwise unexplained male factor infertility.
- According to the Male Infertility Best Practice Policy Committee of the American Urological Association and the Practice Committee of the American Society for Reproductive Medicine.
- Male Infertility In: Sabanegh, E, Agarwal, A, Campbell-Walsh Urology. 10th ed. New York, NY: Elsevier Health Sciences; 2011: 616-647.
- Hotaling JM. Genetics of Male Infertility. Urol Clin N Am. 2014, 41(1): 1-17.
- Stahl PJ, Masson P, Mielnik A, Marean MB, Schlegel PN, Paduch DA. A decade of experience emphasizes that testing for Y microdeletions is essential in American men with azoospermia and severe oligozoospermia. Fertility and Sterility. 2010, 94(5): 1753-1756.