As opposed to screening tests, Prenatal Microarray can provide diagnostic insight for current pregnancies. This test detects clinically significant large (whole chromosome) and submicroscopic (microdeletion/microduplication) copy number changes throughout the genome in fetal cells.
Test details and complementary testing
- This test can be completed concurrently with Prenatal Chromosome Analysis or as a reflex test if Chromosome Analysis does not identify an abnormality.
- In conjunction with Chromosome Analysis, FISH, and/or Microarray, Amniotic Fluid AFP (AF-AFP) can be ordered on amniotic fluid samples with a gestational age of 22 weeks 6 days or less. (AChE should be ordered, instead of AF-AFP, if gestational age is 23 weeks or greater). In most situations if AF-AFP is positive, AChE will be completed. These non-genetic send-out tests can be ordered on our laboratory’s test request form, but are performed, reported, and billed by UNMC Regional Pathology Services and questions for these tests should be directed to their laboratory by calling 402-559-6420.
- Pregnancy Loss Microarray should be ordered instead of this test to analyze cells in a tissue sample after a pregnancy loss.
- Postnatal testing on maternal, paternal, or newborn blood after delivery, including Postnatal Chromosome Analysis, Postnatal FISH, or Postnatal Microarray, must be ordered separately.