The Adaptive Brains - Learning about Emotions (ABLE) Study

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Adaptive Brains - Learning about Emotions (ABLE) Study

Brain Mechanisms Underlying Childhood Anxiety Disorders Study Grant

IRB# 529-21-FB

The goal of this study is to understand how differences in brain function and structure may be related to anxiety in children. We are also interested in studying how differences in your child’s stress hormones or genes (DNA) may be related to these brain differences.  To answer these questions, we are comparing children who are currently anxious with children who have not ever been anxious.

This study requires four visits, three to the Munroe-Meyer Institute and one to the University of Nebraska Imaging Center. First, you will come to the Munroe-Meyer Institute for a 3-hour visit that includes a mental health interview, brief IQ test, and a practice MRI scan. We will ask you and your child to answer some questionnaires at home. Second, you will come to the UNMC Hixon-Lied Center/Core for Advanced Magnetic Resonance Imaging for a 2-hour visit and your child will complete an MRI scan. The MRI scan involves looking at how your child’s brain works while you look at different pictures. We will also collect saliva samples to measure your child’s hormone levels during the scan. For the third and fourth visits, you will come to the Munroe Meyer Institute for your child to complete a computer task and a social task. We will collect saliva samples during both of these visits. Your child will receive compensation for their participation in the study visits.

Your child may be eligible for this study if they:

  1. Your child may be eligible for this study if your child is 8-12 years of age and either does or does not have anxiety.

Your child may not be eligible for this study if they:

  1. Can’t have an MRI due to claustrophobia or metal in their body such as braces
  2. Have a neurological disorder or significant medical illness
  3. Has a developmental disorder such as autism spectrum disorder, dyslexia, or ADHD

Email study staff to learn more about the study.

If you are interested in participating in this study, we would like to ask you several short questions to see if you might be eligible. These questions will take about 5 minutes to complete. If you are interested, answer eligibility questions here.