Departmental Research

Below is a list of active clinical research being conducted in the Department of Neurological Sciences. Please use the Clinical Trials link provided for specific details on these clinical trials as well as other clinical research being conducted at UNMC. 

Title/Description

PI

Recruitment Status

Alzheimer's Disease

Effect of Passive Immunization on the Progression of Mild Alzheimer's Disease: Solanezumab (LY2062430) Versus Placebo

Murman

Recruiting

Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study)

Murman

Recruiting

A Phase 2 multi-center, randomized, double blind, placebo controlled, parallel group study to evaluate the efficacy and safety of T-817MA in patients with mild to moderate Alzheimer's Disease

Murman

Recruiting

ALS

Multicenter ALS Cohort Study of Oxidative Stress and Disease Progression

Fernandes

Phase 2 Study of Rasagiline for Treatment of Amyotrophic Lateral Sclerosis

Fernandes

Recruiting

HDE Post-Approval Study (PAS) of NeuRx DPSP™ for ALS

Fernandes

Recruiting

(ALS) NeuRx DPS, Diaphragm Pacing System

Fernandes

Movement Disorders: Parkinson's Disease

Optimizing Gait in PD Hellman Recruiting
Use of the Personal Kinetigraph Device to Replace On/Off Evaluations in Patients with Parkinson's Disease Torres-Russotto Not yet recruiting
Use of Inosine to Increase CSF and Serum Urate in Patients with Parkinson's Disease Bhatti Not yet recruiting
On vs. Off Driving Evaluation, with Measurement of Risk-Taking Behaviors in Patients with Parkinson's Disease Bertoni Not yet recruiting
ICD Evaluation in Duopa Use in Parkinson's Disease Bertoni Not yet recruiting
Eye Issues in Patients with Parkinson's Disease: Convergence Insufficiency, Retinal Function, Saccadic Function, and Response to Spritz App Bertoni Not yet recruiting
Vitamin Deficiencies in Patients with Parkinson's Disease Bertoni Not yet recruiting
STEADY PD: Efficacy of Isradipine in Patients with Early Parkinson's Disease Bertoni Not yet recruiting
Benefit of Wii Exercise for Patients with Parkinson's Disease Bertoni Recruitment completed

Movement Disorders: Huntington's Disease

Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E) Torres-Russotto Recruitment closed
ENROLL HD: A Prospective Registry Study in a Global Huntington Disease Cohort Hellman Not yet recruiting

Movement Disorders: Other

*Open-Label Continuation Treatment Study With Levodopa-Carbidopa Intestinal Gel in Subjects With Advanced Parkinson's Disease and Severe Motor-Fluctuations Who Have Exhibited A Persistent and Positive Effect to Treatment In Previous Studies* Site #112

Bertoni

Recruitment Closed

Ataxia Examination Test Characteristics

Torres-Russotto

Recruiting

Diagnostic Accuracy of Common Bedside Ataxia Examination Tests

Thompson

Recruiting

Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children Torres-Russotto Not yet recruiting
Deutetrabenazine for the Treatment of Moderate to Severe Tourette Syndrome in Children and Adolescents Torres-Russotto Not yet recruiting
Prevalence and Characteristics of Tremor and Ataxia in Patients with MS Torres-Russotto Not yet recruiting
GPi Deep Brain Stimulation for Refractory Tics and OCD in Patients with Severe Tourette Syndrome Torres-Russotto Not yet recruiting
Evaluation of Psychiatric Comorbidities in Patients with Orthostatic Tremor Torres-Russotto Recruitment completed
Assessment of Balance in Patients with Orthostatic Tremor Torres-Russotto Recruitment completed
Assessment of Ataxia in Patients with Orthostatic Tremor Torres-Russotto Recruitment completed

Multiple Sclerosis

Long-term, prospective, multinational, parallel-cohort study monitoring safety in patients with MS newly started with fingolimod once daily or treated with another approved disease-modifying therapy

Zabad

Recruiting

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy of Natalizumab on Reducing Disability Progression in Subjects With Secondary Progressive Multiple Sclerosis

Zabad

Recruitment Closed

JCV Aantibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri

Zabad

Recruitment Closed

A Randomized, Double-Blind, Double-Dummy, Parallel-Group Study to Evaluate the Efficacy and Safety of Ocrelizumab in Comparison to Interferon Beta-1a (Rebif) in Patients With Relapsing Multiple Sclerosis (“OPERA” Study Program)

Zabad

Recruitment Closed

A Multicenter, Open-Label, 12-Month Observational Study Evaluating the Clinical Effectiveness and Impact on Patient-Reported Outcomes of Oral Tecfidera™ Delayed-Release Capsules in Patients With Relapsing Forms of Multiple Sclerosis After Suboptimal Response to Glatiramer Acetate

Zabad

Recruiting

A Placebo-Controlled Randomized Withdrawal Evaluation of the Efficacy and Safety of Baclofen ER Capsules (GRS) in Subjects with Spasticity Due to Multiple Sclerosis

Zabad

Recruitment Closed

Neuro-Ophthalmology

Changes in Lamina Cribrosa Position after Lumbar Puncture

Kedar

 Recruiting

Parkinson's Disease

A clinical study of Patients with symptomatic neurogenic orthostatic Hypotension to assess sustained effects of Droxidopa therapy

Thai

Phase 3 Double-blind Placebo-controlled Parallel Group Study of Isradipine as a Disease Modifying Agent in Subjects With Early Parkinson Disease

Bertoni

 Recruiting

 Stroke

A Randomized, Placebo Controlled Trial of Pioglitazone, Compared with Placebo for Prevention of Recurrent Stroke and Myocardial Infarction after Ischemic Stroke

Fayad