2013 CHAIN Colloquium

Cellular Interaction and Signaling in NeuroAIDS --- Cellular Interaction and Signaling
Emerging Issues Colloquium

On May 23, 2013 leaders in the neuroAIDS field met at the University of Nebraska Medical Center to discuss cellular interaction and signaling for the third annual HIV and NeuroAIDS colloquium. This meeting continues our series on contemporary issues related to the effects of HIV on the nervous system. In 2011 we focused on animal models, and in 2012 biomarkers. Here, our 2013 meeting featured ten presentations from outstanding scientists examining how inter- and intra-cellular processes contribute to neuropathogenesis. Talks highlighted emerging issues, findings, and potential therapies, followed by a panel discussion in which controversies in the field and gaps in our current knowledge were identified.

The sessions were recorded, and we are pleased to provide a link where you can view all of the presentations and the concluding panel discussion. We thank the speakers for making these available (download the program for speaker bios).

NOTE: to view the videos, you need QuickTime or RealPlayer (click on the name to download the free software).

Welcome and Overview
Howard Fox, MD, PhD, University of Nebraska Medical Center

Speakers (order of presentations):

Lena Al-Harthi, PhD, Rush University
"Neuroimmune Axis in NeuroAIDS: Communication between Astrocytes and T cells through WNT Signaling"

Shilpa Buch, PhD, University of Nebraska Medical Center
"HIV and Morphine Mediated Regulation of Neuronal Dysfunction: Blaming the Messenger"

Sabita Roy, PhD, University of Minnesota Minneapolis
"Morphine Modulation of Gut Barrier Function and Bacterial Translocation Contributes to HIV Neuropathogenesis"

Johnny He, PhD, University of North Texas Health Science Center
"Intercellular HIV-1 Nef Transfer and Its Potential Roles in HIV/NeuroAIDS"

Kelly L. Jordan-Sciutto, PhD, University of Pennsylvania
"Mechanisms of Neurodegeneration in HIV Positive Patients in the Age of Antiretroviral Therapy"

Jay Rappaport, PhD, Temple University
"Monocyte/Macrophage Dynamics in AIDS/NeuroAIDS Pathogenesis"

Howard E. Gendelman, MD, University of Nebraska Medical Center
"NanoART Subcellular Targets Facilitate Clearance of Residual HIV"

Dennis Kolson, MD, PhD, University of Pennsylvania
"Heme Oxygenase-1 and HIV-Mediated Neurodegeneration: Therapeutic Targeting of the Macrophage Antioxidant Response"

Jonathan D. Geiger, PhD, University of North Dakota
"Role of Endolysosomes in Alzheimer's-like Pathology in HAND"

Jialin Zheng, MD, University of Nebraska Medical Center
"Switching Astrogliosis to Neurogenesis: - An Alternative Strategy for the Treatment of HAND"

Panel Discussion 

Sponsored by:
Chronic HIV infection and Aging in NeuroAIDS (CHAIN) Center - PI, Howard Fox

University of Nebraska Medical Center Development Funds - PI, Shilpa Buch

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center

A special thank you to the National Institute of Mental Health for its support of the CHAIN Center.

For additional information contact:

Robin Taylor
Project Coordinator
Department of Pharmacology and Experimental Neuroscience
University of Nebraska Medical Center
985800 Nebraska Medical Center
Omaha, NE  68198-5800