2015 CHAIN Colloquium

Fifth Annual Chronic HIV and Aging in NeuroAIDS Colloquium - May 20, 2015

Mitochondria are key in normal and pathological processes in the body. Their physiological role, including the well-known generation of energy, also includes cellular signaling, differentiation and death as well as other important physiological roles. Recent work unraveling the complex interplay between the mitochondria’s regulation of cellular function and cellular processes that regulate mitochondria themselves have lead to key advances in our knowledge as well as pointed out gaps in our understanding.

This colloquium will address the roles mitochondria play in current disorders afflicting those with HIV, with a focus on the brain. Lessons from the biology and physiology of mitochondrial, aging, neurodegenerative diseases, the effects of therapeutic agents and more will bring together leaders in the field enabling the communication of state of the art knowledge. This forum will enable the communication of state of the art knowledge and how cross-fertilization of overlapping expertise allows us to find ways to address ongoing issues.

Program

Links to recordings

(Windows users, click on .mp4;  Mac users: for best results download VLC Media Player free software then click on .mov)

Welcome.mov   Welcome.mp4

Howard S. Fox, MD, PhD
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center

Strack.mov   Strack.mp4

Stefan Strack, PhD
Molecular and Cellular Biology Program, University of Iowa
"Regulation of mitochondrial fission in the nervous system"

Lewis.mov   Lewis.mp4

William Lewis, MD
Cardiovascular Pathology, Emory University School of Medicine
"NRTIs and Pol gamma hypothesis: continuing controversy or closed case"

Hulgan.mov   Hulgan.mp4

Todd Hulgan, MD, MPH
Department of Medicine-Infectious Diseases, Vanderbilt University
"Mitochondrial DNA variation and neurologic disorders during HIV infection"

Fox.mov   Fox.mp4

Howard S. Fox, MD, PhD
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center
"Mitochondrial function, proteins and metabolites in the aging brain"

Swerdlow.mov   Swerdlow.mp4

Russell H. Swerdlow, MD
Department of Neurology, University of Kansas Medical Center
"Brain aging, Alzheimer's and mitochondria"

Hekimi.mov   Hekimi.mp4

Siegfried Hekimi, PhD, FRSC
Department of Biology, McGill University
"Unexpected relationships between mitochondrial dysfunction, apoptotic signals and aging"

Przedborski.mov   Przedborski.mp4

Serge Przedborski, MD, PhD
Neuroscience Research Lab, Columbia University
"The tale of mitochondria in Parkinson's disease"

Panel.mov   Panel.mp4

Panel Discussion


Hosted and Supported by:

NIH P30 MH062261 (PI: Howard S. Fox, MD, PhD)

University of Nebraska Medical Center Development Fund (PI: Shilpa Buch, PhD)

Department of Pharmacology and Experimental Neuroscience (Howard E. Gendelman, MD, Chair)
University of Nebraska Medical Center

University of Nebraska Medical Center Tobacco Settlement Funds (Jennifer Larsen, MD, Vice Chancellor for Research)

Seahorse Bioscience