Dr. Stauch's Bio
Office Phone: 402-559-4552
My major focus is the role of mitochondrial dysfunction and altered energy metabolism in the context of neurodegenerative diseases and aging. Mitochondrial abnormalities are implicated to play a major role in aging and age-related neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease (PD). Further, HIV appears to increase the risk for several age-associated diseases, including cognitive impairment and antiretroviral drugs are associated with neurotoxic side effects, including mitochondrial toxicity, which likely contribute to the development of HIV-associated neurocognitive disorders (HAND). The goal of my work in the laboratory is to elucidate the mechanisms leading to alterations in mitochondrial energy metabolism in order to develop therapeutic strategies to treat or prevent neurodegeneration.
Immunometabolism in Parkinson’s Disease: Peripheral Markers and Correlation with Neuroimaging.
UNMC CoNDA Pilot Project awarded under NIH/NIGMS 1P20GM130447 (PI: Wilson)
This project investigates if peripheral immunometabolism changes correlate with neuroimaging findings and can be used to evaluate Parkinson’s Disease onset and progression.
Michael J. Fox Foundation 15288
Michael J. Fox Foundation 11845.01 (PI: Fox)
This study examines the hypothesis that enhancing Parkin function mediates increased quality control in conditions of mitochondrial stress.
- Bioenergetic analysis
- Quantitative mass spectrometry (Super-SILAC and SWATH-MS)
- Percoll gradient preparation of synaptosomes and brain mitochondria
- Flow cytometry
- Immunofluorescence microscopy
- Cell culture (primary cells and cell lines)
- Western blots
- Traditional PCRs and Real-Time PCR
Luis D. Estrella
co-mentored with Howard S. Fox
Graduate Research Assistant
Currently recruiting graduate students. Please contact if you are interested.