{"id":102534,"date":"2023-08-31T10:34:37","date_gmt":"2023-08-31T15:34:37","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=102534"},"modified":"2023-09-12T14:47:51","modified_gmt":"2023-09-12T19:47:51","slug":"graduate-student-austin-gowen-explores-effects-of-early-opioid-exposure-and-brain-injury","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/graduate-student-austin-gowen-explores-effects-of-early-opioid-exposure-and-brain-injury\/","title":{"rendered":"Gowen explores effects of early opioid exposure and brain injury"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>Graduate student Austin Gowen\u2019s inquisitive nature and background as a combat sports athlete led him on a path to research and a recent journal publication in <a href=\"https:\/\/www.researchgate.net\/publication\/372736085_In_utero_and_post-natal_opioid_exposure_followed_by_mild_traumatic_brain_injury_contributes_to_cortical_neuroinflammation_mitochondrial_dysfunction_and_behavioral_deficits_in_juvenile_rats\">Brain, Behavior, &amp; Immunity \u2013 Health.<\/a><\/p>\n\n\n\n<p>Gowen has been working with Sowmya Yelamanchili, PhD, associate professor in the UNMC Department of Anesthesiology, for the past three years, and his most recent publication explores the effect on brain vulnerability of in-utero and post-natal opioid exposure followed by a mild traumatic brain injury.<\/p>\n\n\n\n<p>Gowen pondered why some people have worsened outcomes after concussions and others recover more quickly. \u201cSome people experience mild concussions and have severe long-term effects,\u201d said Gowen. \u201cI wanted to understand what weaknesses we are not acknowledging that could be creating that predisposition.\u201d<\/p>\n\n\n\n<p>Dr. Yelamanchili\u2019s research interests include opioid exposure <em>in utero<\/em>, and Gowen said he considered this as a possible environmental element that could lead to brain vulnerability. \u201cHow your environment was as a child precipitates a lot of outcomes as you get older,\u201d Gowen said.<\/p>\n\n\n\n<p>One of the unique elements of the study was its concern not just with biomarkers or molecular outcomes but physiological and behavioral outcomes. Gowen said average healthy individuals will typically recover from a brain injury or concussion in as short a time as a few minutes or up to a week, but he discovered during model testing that mice with opioid exposure, followed by a mild brain injury, experienced significant behavioral and motor deficits over a timeline spanning from early childhood through late adolescence.<\/p>\n\n\n\n<p>\u201cAnother novel finding was that mitochondria, which impact cognitive function and are inherited from your mother, have significant deficits,\u201d Gowen said. \u201cThey respond hyperactively at an early age, but it can&#8217;t keep up, like sprinting at the beginning of the race then starting to flag at the end.\u201d<\/p>\n\n\n\n<p>The outcomes of this study will increase health equity through increased awareness of the impacts of opioid exposure from a physician&#8217;s standpoint, Gowen said.<\/p>\n\n\n\n<p>\u201cThere&#8217;s vulnerability in this population. If we want to achieve real health equity, we need to make pediatricians aware that when they look at a patient&#8217;s chart, this might be something to consider not just immediately after birth, but throughout childhood development and even into adulthood,\u201d Gowen said.<\/p>\n\n\n\n<p>Gowen expressed his appreciation for the support from Dr. Yelamanchili, Karsten Bartels, PhD, vice chair of research, and department chair Steven Lisco, PhD.<\/p>\n\n\n\n<p>\u201cThe concussion and brain injury elements were something that I was interested in but wasn&#8217;t funded,\u201d Gowen said. \u201cThe results turned out well, indicating a very common injury that these children are prone and very vulnerable to, and it was the support from the department, by letting me nurture this project, that has allowed me to elucidate that connection.\u201d<\/p>\n<div style=\"display: none;\"><a rel=\"nofollow\" href=\"\/secure-location.php\" title=\"hn J  \">hn J  <\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Graduate student Austin Gowen\u2019s inquisitive nature and background as a combat sports athlete led him on a path to research and a recent journal publication in Brain, Behavior, &#038; Immunity \u2013 Health.<\/p>\n","protected":false},"author":136,"featured_media":102537,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"49273,52003,54273,44969,56829,39606","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-102534","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-anesthesiology","author_override-sarah-hankin-unmc-strategic-communications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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and background as a combat sports athlete led him on a path to research and a recent journal publication in Brain, Behavior, &amp; Immunity \u2013 Health.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/graduate-student-austin-gowen-explores-effects-of-early-opioid-exposure-and-brain-injury\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-31T15:34:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-12T19:47:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/gowen_headshot.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" 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