{"id":102541,"date":"2023-08-31T10:44:51","date_gmt":"2023-08-31T15:44:51","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=102541"},"modified":"2023-09-12T14:46:49","modified_gmt":"2023-09-12T19:46:49","slug":"researcher-studies-link-between-pesticide-use-and-adhd","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/","title":{"rendered":"Researcher studies link between pesticide use and ADHD"},"content":{"rendered":"
\n

Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received a $423,423 grant from the National Institutes of Health to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.<\/p>\n\n\n\n

Dr. Pendyala said environmental exposure to the pesticide affects children in rural communities and could be an underestimated leading cause of attention-deficit hyperactivity disorder (ADHD).<\/p>\n\n\n\n

\u201cThere are many health risks associated with early exposure, and the risks are greater for children in agricultural communities,\u201d said Dr. Pendyala. \u201cThe impact on Nebraska is very relevant, harming infants exposed in utero, passive transfer to young kids and adolescents working in the fields.\u201d<\/p>\n\n\n\n

Dr. Pendyala said the pyrethroid pesticide is a potent neurotoxin that creates ADHD-like behavior through disruption of dopamine, the toxicity in other areas of the brain has not been determined. His earlier work, including animal models of early life exposure to the pesticide deltamethrin, provides evidence that exposure disrupts brain-derived extracellular vesicles (BDEVs), molecules involved in communication between cells. Exposure to pyrethroids when young also disrupts hippocampus function, directly impacting memory and learning.<\/p>\n\n\n\n

\u201cExposure can lead to behavioral issues often seen in children with ADHD, such as rage, anger and drug addiction,\u201d Dr. Pendyala said. \u201cThese problems can persist into adulthood.\u201d<\/p>\n\n\n\n

The goal of the study is to test the hypothesis that BDEVs are altered by early exposure to DM, causing synaptic injury and impaired synaptic plasticity in the hippocampus.<\/p>\n\n\n\n

Outcomes of this study will provide new insights into the molecular-based understanding of risk factors for neurodevelopmental disorders, in addition to providing guidance for therapeutic development against exposure.<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.<\/p>\n","protected":false},"author":136,"featured_media":102543,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"55837,35133,45133,31174,62612,58271","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-102541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-anesthesiology","author_override-sarah-hankin-unmc-strategic-communications"],"yoast_head":"\nResearcher studies link between pesticide use and ADHD<\/title>\n<meta name=\"description\" content=\"Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researcher studies link between pesticide use and ADHD\" \/>\n<meta property=\"og:description\" content=\"Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-31T15:44:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-12T19:46:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sarah Hankin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@unmc\" \/>\n<meta name=\"twitter:site\" content=\"@unmc\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sarah Hankin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\"},\"author\":{\"name\":\"Sarah Hankin\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8ad95d50430bf77f19802139f3f09371\"},\"headline\":\"Researcher studies link between pesticide use and ADHD\",\"datePublished\":\"2023-08-31T15:44:51+00:00\",\"dateModified\":\"2023-09-12T19:46:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\"},\"wordCount\":274,\"publisher\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\",\"name\":\"Researcher studies link between pesticide use and ADHD\",\"isPartOf\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg\",\"datePublished\":\"2023-08-31T15:44:51+00:00\",\"dateModified\":\"2023-09-12T19:46:49+00:00\",\"description\":\"Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg\",\"contentUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg\",\"width\":900,\"height\":600},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.unmc.edu\/newsroom\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researcher studies link between pesticide use and ADHD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#website\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.unmc.edu\/newsroom\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#organization\",\"name\":\"University of Nebraska Medical Center\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png\",\"contentUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png\",\"width\":500,\"height\":153,\"caption\":\"University of Nebraska Medical Center\"},\"image\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/unmcedu\",\"https:\/\/x.com\/unmc\",\"https:\/\/instagram.com\/iamunmc\",\"https:\/\/www.youtube.com\/user\/UNMCEDU\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8ad95d50430bf77f19802139f3f09371\",\"name\":\"Sarah Hankin\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/author\/42a0e188f5033bc65bf8d78622277c4e\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Researcher studies link between pesticide use and ADHD","description":"Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/","og_locale":"en_US","og_type":"article","og_title":"Researcher studies link between pesticide use and ADHD","og_description":"Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.","og_url":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/unmcedu","article_published_time":"2023-08-31T15:44:51+00:00","article_modified_time":"2023-09-12T19:46:49+00:00","og_image":[{"width":900,"height":600,"url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg","type":"image\/jpeg"}],"author":"Sarah Hankin","twitter_card":"summary_large_image","twitter_creator":"@unmc","twitter_site":"@unmc","twitter_misc":{"Written by":"Sarah Hankin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#article","isPartOf":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/"},"author":{"name":"Sarah Hankin","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8ad95d50430bf77f19802139f3f09371"},"headline":"Researcher studies link between pesticide use and ADHD","datePublished":"2023-08-31T15:44:51+00:00","dateModified":"2023-09-12T19:46:49+00:00","mainEntityOfPage":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/"},"wordCount":274,"publisher":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#organization"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/","url":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/","name":"Researcher studies link between pesticide use and ADHD","isPartOf":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg","datePublished":"2023-08-31T15:44:51+00:00","dateModified":"2023-09-12T19:46:49+00:00","description":"Gurudutt Pendyala, PhD, Robert Lieberman Professor in the UNMC Department of Anesthesiology, received funding to research early life exposure to pyrethroids, a class of pesticides most commonly used in commercial agriculture.","breadcrumb":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#primaryimage","url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg","contentUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2023\/08\/pendyala_900x600.jpg","width":900,"height":600},{"@type":"BreadcrumbList","@id":"https:\/\/www.unmc.edu\/newsroom\/2023\/08\/31\/researcher-studies-link-between-pesticide-use-and-adhd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.unmc.edu\/newsroom\/"},{"@type":"ListItem","position":2,"name":"Researcher studies link between pesticide use and ADHD"}]},{"@type":"WebSite","@id":"https:\/\/www.unmc.edu\/newsroom\/#website","url":"https:\/\/www.unmc.edu\/newsroom\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.unmc.edu\/newsroom\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.unmc.edu\/newsroom\/#organization","name":"University of Nebraska Medical Center","url":"https:\/\/www.unmc.edu\/newsroom\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/","url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png","contentUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png","width":500,"height":153,"caption":"University of Nebraska Medical Center"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/unmcedu","https:\/\/x.com\/unmc","https:\/\/instagram.com\/iamunmc","https:\/\/www.youtube.com\/user\/UNMCEDU"]},{"@type":"Person","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8ad95d50430bf77f19802139f3f09371","name":"Sarah Hankin","url":"https:\/\/www.unmc.edu\/newsroom\/author\/42a0e188f5033bc65bf8d78622277c4e\/"}]}},"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/102541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/users\/136"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/comments?post=102541"}],"version-history":[{"count":2,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/102541\/revisions"}],"predecessor-version":[{"id":102624,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/102541\/revisions\/102624"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/media\/102543"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/media?parent=102541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/categories?post=102541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/tags?post=102541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}