{"id":104459,"date":"2023-10-24T02:00:00","date_gmt":"2023-10-24T07:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=104459"},"modified":"2023-10-24T10:09:40","modified_gmt":"2023-10-24T15:09:40","slug":"unmc-pioneers-combination-of-ai-simulations-and-extended-reality","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2023\/10\/24\/unmc-pioneers-combination-of-ai-simulations-and-extended-reality\/","title":{"rendered":"UNMC pioneers combination of AI, simulations and extended reality"},"content":{"rendered":"
\n

Faculty from the UNMC Division of Cardiovascular Medicine, iEXCEL staff and technology from the Davis Global Center are contributing to the development of breakthroughs using Artificial Intelligence (AI), computational Simulations (S) and Extended Reality (ER). The novel use of these technologies in concert creates not just an acronym, but the first demonstration of a new concept, AISER.<\/p>\n\n\n\n

AI, computational simulation and ER have each become crucial tools. But together, as AISER, \u201ctheir symbiosis and synergy might unlock significant potential in patient-specific health care delivery,\u201d according to a new paper, \u201cArtificial Intelligence, Computational Simulations and Extended Reality: Revolutionary Tools in Cardiovascular Interventions,\u201d<\/a> published Monday in the Journal of American College of Cardiology: Cardiovascular Interventions.<\/p>\n\n\n\n

\u201cThis report demonstrates what can be achieved when the AI that is supporting advanced 3-D imaging at the Davis Global Center is combined with the knowledge and skill of our Nebraska Medicine Interventional Cardiology clinical team,\u201d said UNMC Chancellor Jeffrey P. Gold, MD, one of the paper\u2019s co-authors.<\/p>\n\n\n\n

\u201cThe successful design, 3-D modeling and clinical care will define the future of \u2018serious medicine and extraordinary care,\u2019 \u201d Dr. Gold said.<\/p>\n\n\n

\n
\"\"
The use of Extended Reality (ER), for example, here, exploring a potential stent in a laser-CAVE immersive environment, in combination with Artificial Intelligence (AI) and computational Simulations (S), has shown potential for personalized medicine breakthroughs. The new concept, created in collaboration with iEXCEL and a handful of UNMC faculty, is called AISER.<\/figcaption><\/figure>\n<\/div>\n\n\n

AI and informatics technology are becoming increasingly integrated into health care, and UNMC is among the vanguard. The University of Nebraska established the UNMC Center for Intelligent Health Care (CIHC) in 2020.<\/p>\n\n\n\n

John Windle, MD, Holland Distinguished Chair of Cardiovascular Science, the CIHC\u2019s inaugural director and another of the paper\u2019s co-authors, said that establishing AISER \u201cillustrates the potential that can come from optimizing human and computer integration.\u201d<\/p>\n\n\n\n

A handful of UNMC faculty are authors on the publication, which includes collaborators from across the country, Europe and Asia. Senior and corresponding author of the paper is Yiannis Chatzizisis, MD, PhD, now at the University of Miami\u2019s Miller School of Medicine. Dr. Chatzizisis developed the technology and completed the project while chief of interventional cardiology at UNMC.<\/p>\n\n\n\n

AI can mine and collect patient information, while S, or computational simulation, takes it to the next level through data analysis and prediction of data. And ER\u2019s role? \u201cDisease complexity, interventional procedures and outcomes can be visualized and learned with extended reality (ER),\u201d the authors wrote.<\/p>\n\n\n\n

ER is where iEXCEL comes in. \u201cThey (Dr. Chatzizisis and cardiovascular faculty) brought us all of their data, but they didn\u2019t have a good way to visualize or experience it,\u201d said Bill Glass, artistic director, iEXCEL visualization. But Glass and the iEXCEL team created next-level models. \u201cWe were one of the first to combine different imaging modalities into one and run it as a simulation,\u201d he explained.<\/p>\n\n\n\n

Pamela Boyers, PhD, associate vice chancellor of clinical simulation and iEXCEL, is another of the study\u2019s co-investigators from UNMC.<\/p>\n\n\n\n

The use of 3-D modeling through ER, and iEXCEL, proved to be the missing piece to AI and computational simulations \u2013 and vice versa.<\/p>\n\n\n\n

Through AISER, investigators can instantaneously run through 1,000 or more variations to come up with the best candidates for turning population-sized data sets into personalized precision medicine. For example, creating ER models of potential new heart stents in action, then using patient data and computer programming to see which design would work best.<\/p>\n\n\n\n

“It is exciting to see the impact of using AI not only to acquire data but to simulate clinical outcomes,\u201d said Daniel Anderson, MD, PhD, another co-investigator. \u201cIt is impressive to be able to predict how a stent will deploy in a coronary artery when different segments within the area of deployment area are calcified, fibrosed and\/or include a soft, fatty plaque.\u201d<\/p>\n\n\n\n

Computational stent simulations by Dr. Chatzizisis, iEXCEL and team, and collaboration with industry helped lead to the invention of a new stent, specifically designed for larger and stiffer heart vessels.<\/p>\n\n\n\n

The first of these new stents were successfully implanted in two patients<\/a> at the Nebraska Medical Center in 2021.<\/p>\n\n\n\n

Through AISER, Dr. Anderson said, \u201cWe will not only better refine our pre-clinical and clinical research trials, but also enable providers to select appropriate stents and deliver a personalized treatment strategy for atheromatous lesions. Thus, we continue to streamline and elevate our translational clinical research efforts and clinical practice.”<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

New publication in Journal of American College Cardiology: Cardiovascular Interventions explores 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