{"id":107667,"date":"2024-02-07T15:37:00","date_gmt":"2024-02-07T21:37:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=107667"},"modified":"2024-03-26T08:49:01","modified_gmt":"2024-03-26T13:49:01","slug":"hanjun-wang-md-receives-funding-to-investigate-a-common-symptom-of-chronic-heart-failure","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2024\/02\/07\/hanjun-wang-md-receives-funding-to-investigate-a-common-symptom-of-chronic-heart-failure\/","title":{"rendered":"Hanjun Wang, MD, receives funding to investigate  a common symptom of chronic heart failure"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>Hanjun Wang, MD, Margaret R. Larson Professor of Anesthesiology in the UNMC Department of Anesthesiology, is investigating the neural mechanisms behind a common symptom of chronic heart failure \u2013 exercise-induced respiratory difficulty.<\/p>\n\n\n\n<p>Dr. Wang\u2019s research, funded by a $2.5 million R01 grant, began in August and will run for the next four years.<\/p>\n\n\n\n<p>Dr. Wang said chronic heart failure significantly diminishes a patient\u2019s quality of life and is a leading cause of death in the United States. His study, \u201cNeural inflammation and exercise pressor reflex in heart failure,\u201d will explore how the peripheral nervous system, when activated during exercise, influences blood redistribution and triggers respiratory difficulties.<\/p>\n\n\n\n<p>\u201cHeart failure isn\u2019t solely an issue originating from the heart,\u201d Dr. Wang said. \u201cThe heart is an engine, much like a car. So, if your engine has a problem, you can probably still drive, but the other components within the system will begin to fail one by one.\u201d<\/p>\n\n\n\n<p>Dr. Wang emphasized the role of inflammation of the peripheral nervous system in exacerbating exercise-induced respiratory difficulties.<strong><\/strong><\/p>\n\n\n\n<p>\u201cOne goal of the study is to uncover the neural processes involved during exercise, with the intention of using this knowledge as a therapeutic target,\u201d Dr. Wang said. \u201cThe idea is to develop a drug that could enhance exercise capacity without directly targeting the damaged heart.\u201d<\/p>\n\n\n\n<p>In collaboration with Dong Wang, PhD, professor in&nbsp;UNMC\u2019s College&nbsp;of Pharmacy in the&nbsp;department&nbsp;of pharmaceutical sciences, Dr. Wang aims to develop a drug delivery system, using nanoparticle prodrugs, to selectively target neural inflammation without causing systemic side effects.<\/p>\n\n\n\n<p>\u201cDeveloping these therapies will increase the exercise capacity and reduce cardiovascular dysfunction in patients with chronic heart failure,\u201d Dr. Wang said. \u201cAnother benefit is the patient will avoid having to undergo surgery.\u201d<\/p>\n\n\n\n<p>Dr. Wang is grateful for the collaborative work with UNMC\u2019s Department&nbsp;of Pharmaceutical Sciences and said this type of interdisciplinary research ultimately leads to more funding.<\/p>\n\n\n\n<p>Dr. Wang also acknowledged the strong support researchers receive from department leadership, specifically Steven Lisco, MD, former chair of the department; Mohanad Shukry, MD, PhD, interim chair; and Karsten Bartels, MD, PhD, vice chair of research.<\/p>\n\n\n\n<p>\u201cDepartment leaders foster an environment conducive to groundbreaking studies, enabling the exploration of novel ideas,\u201d Dr. Wang said. \u201cTheir trust and investment provide the resources that enable us to gather preliminary data, essential for obtaining larger grants.\u201d<\/p>\n\n\n\n<p>Dr. Bartels said anesthesiology is, at its core, a highly collaborative specialty and the department is committed to providing innovative researchers with a supportive environment to develop ground-breaking, high-risk, high-reward proposals.<\/p>\n\n\n\n<p>\u201cMost recently, our department climbed to No. 28 in funding amongst all anesthesiology departments listed in the National Institutes of Health report,\u201d Dr. Bartels said. \u201cWe are being noticed for punching above our weight, and the credit for doing so goes to our brilliant scientists, our dedicated students and postdocs, and the terrific staff who are making the magic happen &#8212; day in and day out.\u201d<\/p>\n\n\n\n<p>Dr. Shukry said UNMC and the department of anesthesiology are fortunate to have a scientist of Dr. Wang\u2019s caliber. \u201cDr. Wang\u2019s cutting-edge research will benefit many patients and possibly delay or prevent heart failure,\u201d he said. \u201cHis collaborative efforts are commendable and his positive contribution to scientific discovery is praiseworthy.\u201d<\/p>\n\n\n\n<p>Dr. Wang earned his medical and Master of Science degrees at Nanjing Medical University in China, then came to UNMC in 2007 as a postdoctoral fellow in the UNMC Department of Cellular &amp; Innovative Physiology. He joined the Department of Cellular and Integrative Physiology as a faculty member in 2012, working closely with Irving H. Zucker, PhD, on cardiovascular research before joining the UNMC Department of Anesthesiology in April 2016.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Hanjun Wang, MD, Margaret R. Larson Professor of Anesthesiology in the UNMC Department of Anesthesiology, is investigating the neural mechanisms behind a common symptom of chronic heart failure \u2013 exercise-induced respiratory difficulty.<\/p>\n","protected":false},"author":136,"featured_media":107670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"59226,44358,101793,35160,38661,40967","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-107667","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-anesthesiology","author_override-sarah-hankin-unmc-strategic-communications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hanjun Wang, MD, receives funding to investigate a common symptom of chronic heart failure<\/title>\n<meta name=\"description\" content=\"Hanjun Wang, MD, Margaret R. 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