{"id":108093,"date":"2024-02-20T02:00:00","date_gmt":"2024-02-20T08:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=108093"},"modified":"2024-02-19T15:20:45","modified_gmt":"2024-02-19T21:20:45","slug":"unmc-parkinsons-research-leads-to-licensing-partnership","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2024\/02\/20\/unmc-parkinsons-research-leads-to-licensing-partnership\/","title":{"rendered":"UNMC Parkinson’s research leads to licensing partnership"},"content":{"rendered":"
\n

An innovative approach to treat Parkinson’s disease, pioneered at UNMC, could reach patients within the next year as part of a clinical trial.<\/p>\n\n\n\n

Howard Gendelman, MD, and Lee Mosley, PhD, initially identified ld-IL-2 monotherapy \u2014 short for low dose interleukin-2 \u2014 as a potential treatment for Parkinson\u2019s disease. At the same time, Coya Therapeutics was pioneering work with ld-IL-2 to target multiple neurodegenerative conditions and had generated highly promising clinical data in ALS and Alzheimer\u2019s disease. The promising data generated by UNMC in Parkinson\u2019s disease led to a licensing partnership with Coya.<\/p>\n\n\n\n

UNMC experiments showed that ld-IL-2 can be particularly effective for use in patients suffering from Parkinson’s. In a recent publication<\/a>, Dr. Gendelman, chair of the UNMC Department of Pharmacology and Experimental Neuroscience (PEN), and Dr. Mosley, a professor and director of the neurodegenerative disease program in UNMC\u2019s PEN department, report that ld-IL-2 stimulates a robust anti-inflammatory response with regulatory T-cells, or Tregs, which can protect brain cells from the kind of damage found in Parkinson’s.<\/p>\n\n\n\n

In June 2023, UNMC’s technology transfer office, UNeMed, licensed the intellectual property relating to the use of ld-IL-2 to Coya Therapeutics for further development and commercialization in Parkinson\u2019s disease.<\/p>\n\n\n\n

Dr. Gendelman extended the research with ld-IL2 to combination approaches with another cytokine, granulocyte macrophage-colony stimulating factor, or GM-CSF. GM-CSF is a potent immune modulator known to promote Treg activities and dampen pro-inflammatory responses. Preclinical data \u2014 generated by the Gendelman and Mosley laboratories \u2014 demonstrated that the combination of ld-IL-2 with GM-CSF resulted in a synergistic four- to six-fold increase in Tregs compared to treatments with either cytokine alone.<\/p>\n\n\n\n

Earlier this month, UNeMed additionally licensed the use of ld-IL-2\/GM-CSF to Coya Therapeutics for further development and commercialization in multiple inflammatory diseases, including neurodegenerative and autoimmune conditions.<\/p>\n\n\n\n

\u201cWe believe that Treg dysfunction is the common thread that binds together many neurodegenerative diseases,” Coya Chief Business Officer, Arun Swaminathan, PhD, said in a recent press release. “These two licenses are based on strong preclinical animal data and builds upon the highly promising clinical data observed in ALS and AD, and expands the optionality that Coya has in strategic partnering discussions to execute on future clinical trials in Parkinson\u2019s disease.\u201d<\/p>\n\n\n\n

Said UNeMed President and CEO, Michael Dixon, PhD: \u201cWe are incredibility excited about this partnership. Coya is in a great position to develop this new therapy and bring it to the market, where it can have a significantly positive impact on health care.”<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

UNeMed licensed a UNMC-developed monotherapy to Coya Therapeutics for further development in multiple inflammatory diseases.<\/p>\n","protected":false},"author":75,"featured_media":108094,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"22526,40485,65757,56392,51347,39165","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-108093","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-pharmacology-and-experimental-neuroscience","department-unmc-front-page","department-unmc-today-todays-headlines","author_override-charlie-litton-unemed"],"yoast_head":"\nUNMC Parkinson's 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