{"id":116835,"date":"2024-11-10T19:46:38","date_gmt":"2024-11-11T01:46:38","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=116835"},"modified":"2024-11-12T18:45:59","modified_gmt":"2024-11-13T00:45:59","slug":"medical-research-highlights-november-2024","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/10\/medical-research-highlights-november-2024\/","title":{"rendered":"Medical research highlights, November 2024"},"content":{"rendered":"
\n

The UNMC College of Medicine received grant and funding awards representing more than $7 million in new funding in September.  Awards included:<\/p>\n\n\n\n

Bin Duan, PhD,<\/strong> internal medicine-cardiovascular, received a grant of $750,000 from the American Heart Association for an analysis of plasma derived sEVs by combining SERS spectroscopy and machine learning for CAD diagnosis and prognosis.<\/p>\n\n\n\n

Hanjun Wang, MD,<\/strong> anesthesiology, received a grant of $741,512 from DHHS\/NIH\/NHLBI for a study on stellate ganglia Nrf2 signaling and enhanced cardiac sympathetic tone in chronic heart failure.<\/p>\n\n\n\n

Siddappa Byrareddy, PhD,<\/strong>\u00a0pharmacology and experimental neuroscience, received a grant of $690,750 from the DHHS\/NIH\/NIDA for a study on sex differences in modulating HIV\/SIV reservoirs in the context of opioid.<\/p>\n\n\n\n

Kurt Fisher, MD, PhD,<\/strong> pathology, microbiology and immunology, received a grant of $439,367 from DHHS\/NIH\/NCI for an assessment of strategies for targeting transcriptional co-activators in colorectal cancer.<\/p>\n\n\n\n

Prasanta Dash, PhD,<\/strong> pharmacology and experimental neuroscience, received a grant of $383,750 from DHHS\/NIH\/NIA for a study exploring the molecular, neuro-immune and behavioral changes during HIV-associated progressive aging using a long-term humanized mice model.<\/p>\n\n\n\n

Saraswathi Vishwanathan, PhD,<\/strong> internal medicine-DEM, received a grant of $374,081 from the DHHS\/NIH\/NIAAA for the study \u201cRedox Signaling and AMPK Crosstalk on Alcohol-Induced Multi-Organ Damage: Liver and Adipose Tissue.\u201d<\/p>\n\n\n\n

Karsten Bartels, MD, PhD,<\/strong> anesthesiology, received a grant of $330,829 from DHHS\/NIH\/NIAAA for the study \u201cLeveraging Alcohol Use Disorder Screening for Treatment in Routine Perioperative Care.\u201d<\/p>\n\n\n\n

Channabasavvaiah Gurumurthy, PhD,<\/strong> genetics, cell biology and anatomy, received a grant of $330,025 from DHHS\/NIH\/NIGMS for \u201cPrototype Mouse Models for SEND-Based mRNA Delivery and Technology Development.\u201d<\/p>\n\n\n\n

Shibiao Wan, PhD,<\/strong> genetics, cell biology and anatomy, received a grant of $307,000 from DHHS\/NIH\/Office of the Director for a study on leveraging heterogenous common fund data sets and beyond for identifying lung cancer subtypes.<\/p>\n\n\n\n

Arpan Acharya, PhD,<\/strong> pharmacology and experimental neuroscience, received a grant of $300,000 from DHHS\/NIH\/Office of the Director for a study on SIV reservoirs dynamics during aging.<\/p>\n\n\n\n

Steven Yeh, MD,<\/strong> ophthalmology and visual sciences, received a grant of $247,932 from Emory University for COVID-19 Eye substudy in the RECOVER consortium. Dr. Yeh also received a grant of $50,000 from the Retina Society for the study \u201cMolecular and immunologic mechanisms of HIV- and non-HIV-related CMV retinitis: A global approach to disease understanding.\u201d<\/p>\n\n\n\n

Keshore Bidasee, PhD,<\/strong> pharmacology and experimental neuroscience, received a grant of $230,250 from DHHS\/NIH\/NINDS for a study exploring neurological disorders in HIV-1 infection.<\/p>\n\n\n\n

Lisa Rucks, PhD,<\/strong> pathology, microbiology and immunology, received a grant of $207,225 from DHHS\/NIH\/NIAID for the study \u201cChlamydia trachomatis manipulates (PI)CALM to carry on.\u201d<\/p>\n\n\n\n

Kelly Stauch, PhD,<\/strong> neurological sciences, received a grant of $200,000 from the Alzheimer\u2019s Association for the study \u201cThe Role of APOE4 in Synaptic Mitochondrial Dysfunction.\u201d<\/p>\n\n\n\n

Peter Murphy, MD,<\/strong> internal medicine-pulmonary, received a grant of $186,910 from the Cystic Fibrosis Foundation for the CFF Center Adult Program.<\/p>\n\n\n\n

Joseph Americo Fernandes, MD,<\/strong> neurological sciences, received a grant of $183,733 from Massachusetts General Hospital for the \u201cMaster Agreement: ALL ALS East – ALL ALS Consortium Project.\u201d<\/p>\n\n\n\n

Christopher Barrett, MD,<\/strong> surgery-acute care, received a grant of $120,096 from DHHS\/NIH\/NHLBI for a study of mechanisms of complement activation in traumatic injury.<\/p>\n\n\n\n

Cyrus Desouza, MBBS, <\/strong>internal medicine-DEM, received a grant of $66,482 from the Nebraska Educational Biomedical Research Foundation as the Nebraska ICA for Reagan TeKolste. Dr. DeSouza also received a grant of $43,422 from the Nebraska Educational Biomedical Research Foundation as the Nebraska ICA for Susan Burbach, and a grant of $22,759 from the Nebraska Educational Biomedical Research Foundation as the Nebraska ICA for Ally Thavenet.<\/p>\n\n\n\n

Sara Bares, MD,<\/strong>\u00a0internal medicine-infectious diseases, received a grant of $30,987 from Massachusetts General Hospital for \u201cEMPOWHer: Embracing Midlife & Menopause Positively-Offerings by Women with HIV.\u201d<\/p>\n\n\n\n

Shan Fan, MD,<\/strong> ophthalmology and visual sciences, received a grant of $22,677 from the University of Georgia for a study on the effect of suprachoroidal space hydrogel injection on aqueous humor dynamics.<\/p>\n\n\n\n

Sidharth Mahapatra, MD, PhD,<\/strong>\u00a0pediatrics-critical care, received a grant of $17,192 from the University of Pennsylvania for PROSpect – Prone and Oscillation Pediatric Clinical Trial.<\/p>\n\n\n\n

Iraklis Pipinos, MD,<\/strong> surgery-vascular surgery, received a grant of $16,544 from the University of Nebraska at Omaha for \u201cCollaborative Research: Detecting Gait Phases with Raised Metabolic Cost using Robotic Perturbations and System Identification for Enabling Targeted Rehabilitation Therapy.\u201d<\/p>\n\n\n\n

Erica Stohs, MD,<\/strong> internal medicine-infectious diseases, received a grant of $16,059 from the University of Washington for a study of cytomegalovirus (CMV) vaccine in orthotopic liver transplant candidates.<\/p>\n\n\n\n

Carol Casey, PhD,<\/strong> internal medicine-GI, received a grant of $15,629 from the University of Nebraska-Lincoln for the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules.<\/p>\n\n\n\n

Ram Subramanyan, MD, PhD,<\/strong> surgery-cardiothoracic surgery, received a grant of $4,000 from the New England Research Institutes for comparison of methods of pulmonary blood flow augmentation in neonates: Shunt vs. stent.<\/p>\n\n\n\n

Industry-sponsored grants and contracts:<\/strong><\/p>\n\n\n\n

The following industry-sponsored grants and contracts were received.<\/p>\n\n\n\n

Omar Abughanimeh, MBBS, <\/strong>internal medicine-oncology\/hematology, received funding for a study to evaluate novel immunotherapy combinations as first-line treatment in participants with recurrent\/metastatic PD-L1 positive squamous cell carcinoma of the head and neck.<\/p>\n\n\n\n

Sookyong Koh, MD, PhD, <\/strong>pediatrics-neurology, received funding for a trial of EPX-100 (Clemizole Hydrochloride) as adjunctive therapy in children and adult participants with Dravet syndrome.<\/p>\n\n\n\n

Laura Graeff-Armas, MD, PhD, <\/strong>internal medicine-DEM, received funding for a trial to evaluate the safety, pharmacokinetics and efficacy of MBX 2109 in patients with hypoparathyroidism<\/p>\n\n\n\n

Sarah Lonowski, MD, <\/strong>dermatology, received funding for a trial to evaluate the efficacy and safety of Anifrolumab in adults with chronic and\/or subacute cutaneous lupus erythematosus.<\/p>\n\n\n\n

Ashley Deschamp, MD, <\/strong>pediatrics-pulmonary, received funding for \u201cA Natural History Study of Exocrine Pancreatic Function in Infants With Cystic Fibrosis Less Than 12 Months of Age.\u201d<\/p>\n\n\n\n

Scott Koepsell, MD, PhD,<\/strong> pathology, microbiology and immunology, received funding for a study of HemosIL CL ADAMTS13 activity on the ACL TOP 970 CL and\/or HemosIL AcuStar ADAMTS13 activity on the ACL AcuStar Protocol – sample collection.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

The college received grant\u00a0and funding awards representing more than $7 million in new funding in September.<\/p>\n","protected":false},"author":27,"featured_media":92473,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"57432,55234,37703,52604,44300,32745","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-116835","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-anesthesiology","department-biochemistry-and-molecular-biology","department-college-of-medicine","department-dermatology","department-genetics-cell-biology-and-anatomy","department-intercom","department-internal-medicine","department-neurological-sciences","department-ophthalmology-and-visual-sciences","department-pathology-and-microbiology","department-pediatrics","department-pharmacology-and-experimental-neuroscience","department-surgery","author_override-intercom"],"yoast_head":"\nMedical 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