{"id":118568,"date":"2025-03-11T11:07:14","date_gmt":"2025-03-11T16:07:14","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=118568"},"modified":"2025-03-11T14:44:21","modified_gmt":"2025-03-11T19:44:21","slug":"medical-research-highlights-february-2025","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2025\/03\/11\/medical-research-highlights-february-2025\/","title":{"rendered":"Medical research highlights, March 2025"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>The UNMC College of Medicine received grants&nbsp;and awards representing more than $15 million in new funding in November, December and January. &nbsp;Awards included:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cyrus Desouza, MBBS,\u00a0<\/strong>internal medicine-DEM, received a grant of $1,443,750 from Brigham &amp; Women\u2019s Hospital for the \u201cPREvention of CardIovascular and DiabEtic kidNey disease in Type 2 Diabetes (PRECIDENTD) Study.\u201d<\/li>\n\n\n\n<li><strong>Benson Edagwa, PhD,<\/strong>&nbsp;pharmacology and experimental neuroscience, received a grant of $744,473 from the DHHS\/NIH\/NIAID for the study \u201cProdrug Formulations Create Sustained Release Antiretrovirals.\u201d<\/li>\n\n\n\n<li><strong>Birgit Khandalavala, MBBS,<\/strong>&nbsp;family medicine, received a grant of $731,968 from Duke University for the study \u201cEvaluating Inclisiran as a solution to improve LDL-C management and close care gaps in an inclusive ASCVD and ASCVD risk-equivalent population.\u201d<\/li>\n\n\n\n<li><strong>Mohan Krishnan, PhD,<\/strong>\u00a0biochemistry and molecular biology, received a grant of $415,832 from DHHS\/NIH\/NICHD for the study \u201cRBC transfusion exacerbates brain inflammation in anemic murine neonates and causes long term neurodevelopment impairment.\u201d<\/li>\n\n\n\n<li><strong>Carol Geary, PhD,<\/strong>&nbsp;pathology, microbiology and immunology, received a grant of $299,991 from the Patient-Centered Outcomes Research Institute for research capacity building in rural Nebraska; and $80,000 from University of Missouri for the PCORnet\u00ae Enhancement Project: Enhancing Capacity of the PCORnet\u00ae Common Data Model to Support Patient-Centered Comparative Clinical Effectiveness Research.<\/li>\n\n\n\n<li><strong>Jennifer Bailey-Lundberg, PhD,<\/strong>&nbsp;pathology, microbiology and immunology, received a grant of $277,374 from the University of Texas Health Science Center at Houston for a study to evaluate the safety and efficacy of combination systemic chemotherapy and multiple rounds of endoscopic ultrasounds-guided radiofrequency ablation in pancreatic cancer.<\/li>\n\n\n\n<li><strong>So-Youn Kim, PhD,<\/strong>&nbsp;obstetrics\/gynecology, received a grant of $264,861 from Rutgers Biomedical and Health Sciences for a study of oogenic JNK in gonadotoxic chemotherapy-induced primary ovarian insufficiency.<\/li>\n\n\n\n<li><strong>Kelly Stauch, PhD,<\/strong>&nbsp;neurological sciences, received a grant of $257,617 from the Michael J. Fox Foundation for a study elucidating the role of PINK1\/PRKN in cell type-specific responses to alpha-synuclein pathology.<\/li>\n\n\n\n<li><strong>Joseph Americo Fernandes, MD,<\/strong>&nbsp;neurological sciences, received a grant of $250,000 from Massachusetts General Hospital for a master agreement: ALL ALS East \u2013 ALL ALS Consortium project.<\/li>\n\n\n\n<li><strong>Mike Wiley, PhD,<\/strong>&nbsp;pathology, microbiology and immunology, received a grant of $231,778 from the National Strategic Research Institute for \u201cTargeted Acquisition of Reference Materials Augmenting Capabilities (TARMAC) Initiative Next Generation Sequencing (NGS) Research Support \u2013 Year Two.\u201d<\/li>\n\n\n\n<li><strong>Matthew Lunning, DO,<\/strong>&nbsp;internal medicine-oncology\/hematology, received a grant of $229,140 from West Virginia University for \u201cIncreasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and Workforce Development.\u201d Dr. Lunning also received a grant of $7,753 from the University of Pennsylvania for a study of dual targeting of CD19 and CD20 antigens using sequential CD19-directed CAR-T cells followed by Mosunetuzumab or Glofitamab in relapsed or refractory diffuse large B-cell or transformed follicular lymphomas.<\/li>\n\n\n\n<li><strong>Chi Zhang, MD, PhD,<\/strong>&nbsp;radiation oncology, received a grant of $90,000 from Nebraska DHHS for the study of theranostic roles of miR-210 in glioma stem cells. Dr. Zhang also received a grant of $125,700 from the NRG Oncology Foundation for a master agreement.<\/li>\n\n\n\n<li><strong>Maher Abdalla, PhD,<\/strong>&nbsp;pathology, microbiology and immunology, received a grant of $211,749 from the American Cancer Society for the study \u201cTargeting Heme Oxygenase-1 Enhances Standard Chemotherapy in Pancreatic ductal adenocarcinoma.\u201d<\/li>\n\n\n\n<li><strong>Wallace Thoreson, PhD,&nbsp;<\/strong>ophthalmology and visual sciences, received a grant of $190,538 from DHHS\/NIH\/NEI for a study using optical sensors to measure synaptic glutamate release from retinal rod photoreceptor cells.<\/li>\n\n\n\n<li><strong>Bernd Fritzsch, PhD,<\/strong>&nbsp;neurological sciences, received a grant of $165,000 from the University of Arizona for a study on determinants of age-induced hearing loss and reversal strategies.<\/li>\n\n\n\n<li><strong>Melissa Cullimore, MD, PhD,<\/strong>&nbsp;pediatrics-critical care, received a grant of $118,330 from Boston Children\u2019s Hospital for a study on respiratory virus surveillance and COVID-19 vaccine effectiveness (VE) in preventing severe COVID-19, multisystem inflammatory syndrome (MIS-C) and related complications in U.S. children.<\/li>\n\n\n\n<li><strong>Jason MacTaggart, MD,<\/strong>&nbsp;surgery-vascular surgery, received a grant of $105,777 from the University of Nebraska at Omaha for \u201cAxially Prestretched Elastomeric Nanofibrillar Graft (APENG) for Lower Extremity Arterial Bypass.\u201d<\/li>\n\n\n\n<li><strong>John Davis, PhD,<\/strong>&nbsp;obstetrics\/gynecology, received a grant of $95,987 from Kings College London for the study \u201cUnderstanding the Role Of FSHR Oligomerization and Trafficking in Transducing Age-dependent Changes In FSH Glycoforms.\u201d<\/li>\n\n\n\n<li><strong>Ruirui Liu, PhD,<\/strong>&nbsp;radiation oncology, received a grant of $93,325 from Glebe Medical Research Foundation-NU Foundation for the study \u201cDevelopment of a proton SBRT FLASH treatment technique with integrated biological optimization using patient-specific 3D ridge filters for lung cancer patients.\u201d<\/li>\n\n\n\n<li><strong>Scott Lundgren, DO,<\/strong>&nbsp;internal medicine-cardiovascular, received a grant of $86,847 from Colorado Prevention Center for a trial to determine the efficacy and safety of finerenone on morbidity and mortality among heart failure patients.<\/li>\n\n\n\n<li><strong>Sidharth Mahapatra, MD, PhD,<\/strong>&nbsp;pediatrics-clinical care, received a grant of $76,750 from the American Heart Association for the study \u201cSilencing B7-H3 mitigates tumor aggressiveness in group 3 medulloblastoma.\u201d<\/li>\n\n\n\n<li><strong>Samuel Gillman,<\/strong>&nbsp;genetics, cell biology and anatomy, received a grant of $69,550 from the American Heart Association for the study \u201cA New Potential Regulator of Respiratory Homeostasis: The Role of the Afferent Vagal C-Fiber in the Hering-Bruer Reflex.\u201d<\/li>\n\n\n\n<li><strong>Jasmine Marcelin, MD,<\/strong>&nbsp;internal medicine-infectious diseases, received a grant of $62,984 from Northwestern University Feinberg School of Medicine for a study evaluating equity in antibiotic stewardship and disparities in appropriateness of antibiotic treatment.<\/li>\n\n\n\n<li><strong>Michele Aizenberg Ansari, MD,<\/strong>&nbsp;neurosurgery, received a grant of $55,478 from the University of Pennsylvania for a study of dMRI-based visualization of non-enhancing tumor for guiding supra-total resection of high-grade gliomas.<\/li>\n\n\n\n<li><strong>Andy Vasey, MD,<\/strong>&nbsp;internal medicine-general medicine, received a grant of $48,561 from the University of Mississippi Medical Center for a study of Immulina as an antiviral immune modulator for patients with PASC and persistent inflammation.<\/li>\n\n\n\n<li><strong>Rebecca Deegan, PhD,<\/strong>&nbsp;biochemistry and molecular biology, received a grant of $38,375 from Columbia University for a study of gut microbiome-focused approaches for improving treatment of acute radiation injuries.<\/li>\n\n\n\n<li><strong>Abigail Hall,<\/strong>&nbsp;pathology, microbiology and immunology, received a grant of $34,774 from the American Heart Association for the study \u201cRegulation of Thiol Homeostasis by the Spx Redox Switch.\u201d<\/li>\n\n\n\n<li><strong>Laura Graeff-Armas, MD, PhD,&nbsp;<\/strong>internal medicine-DEM, received a grant of $28,022 from Nebraska Educational Biomedical Research Association as the Nebraska ICA for ZEUS Project for Jenna Eggert.<\/li>\n\n\n\n<li><strong>Melissa Thoene, PhD,&nbsp;<\/strong>pediatrics-newborn medicine, received a grant of $25,000 from ASPEN Rhoads Research Foundation for \u201cEvaluation of the Nutritional Antioxidant Content of Feedings for Hospitalized Infants Based on Standard Clinical Practices for Storage, Preparation, and Delivery.\u201d<\/li>\n\n\n\n<li><strong>Peng Zhong, PhD,&nbsp;<\/strong>neurological sciences, received a grant of $25,000 from Nebraska EPSCOR for a study on excitatory control of sleep in the mammalian brain.<\/li>\n\n\n\n<li><strong>Keely Buesing, MD,<\/strong>&nbsp;surgery-acute care, received a grant of $22,617 from Johns Hopkins University for the study \u201cDriving Pressure-Limited Ventilation in Hypoxemic Respiratory Failure.\u201d<\/li>\n\n\n\n<li><strong>Stephen Rennard, MD,<\/strong>&nbsp;internal medicine-pulmonary, received a grant of $16,378 from University of Nebraska-Lincoln for a study of a multimodal wearable device with distributed AI framework to access physiologic connectivity for health status.<\/li>\n\n\n\n<li><strong>Ellen Kerns, PhD,&nbsp;<\/strong>pediatrics-biomedical informatics, received a grant of $12,500 from the American Academy of Pediatrics as a consulting contract.<\/li>\n\n\n\n<li><strong>Russell McCulloh, MD,&nbsp;<\/strong>pediatrics-biomedical informatics, received a grant of $7,675 from the University of Arkansas for Medical Sciences for \u201cThe BREATHE Study: Bronchiolitis Recovery and the Use of High Efficiency Particle Air (HEPA) Filters.\u201d<\/li>\n\n\n\n<li><strong>Marat Sadykov, PhD,&nbsp;<\/strong>pediatrics-infectious diseases, received a NASA Nebraska Space Grant of $5,000 for a study evaluating personal protection materials in near-space environments using bacteria and spores on a high-altitude platform.<\/li>\n\n\n\n<li><strong>Shirley Delair, MD,&nbsp;<\/strong>pediatrics-infectious diseases, received a grant of $5,000 from the University of Colorado Denver for \u201cThe INFLUENTIAL Trial- Inpatient FLU Vaccination Program Effectiveness: National Trial Implementing Best Practices and Learning Collaboratives.\u201d<\/li>\n\n\n\n<li><strong>Jill Beck, MD,&nbsp;<\/strong>pediatrics-hematology-oncology, received a grant of $3,070 from the Research Institute at Nationwide Children\u2019s Hospital for a study of PET\/CT imaging for evaluating vascular inflammation and risk for venous thromboembolism in pediatric, adolescent and young adult oncology.<\/li>\n<\/ul>\n\n\n\n<p><strong>Industry-sponsored grants and contracts:<\/strong><\/p>\n\n\n\n<p>The following industry-sponsored grants and contracts were received.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Benjamin Tepley, MD,<\/strong>&nbsp;internal medicine-oncology\/hematology, received funding for a study of MK-5684 vs. alternative Abiraterone Acetate or Enzalutamide in participants with Metastatic castration-resistant prostate cancer (mCRPC) previously treated with next-generation hormonal agent.<\/li>\n\n\n\n<li><strong>Michael Hadaddin, MBBS,<\/strong>&nbsp;internal medicine-oncology\/hematology, received funding for a study to evaluate the safety and efficacy of Axatilimab in combination With Ruxolitinib in participants with newly diagnosed chronic graft-versus-host disease.<\/li>\n\n\n\n<li><strong>Tanya Wildes, MD,<\/strong>&nbsp;internal medicine-hematology\/oncology, received funding for a study comparing Talquetamab in combination with Pomalidomide (Tal-P), Talquetamab in Combination with Teclistamab (Tal-Tec), and investigator\u2019s choice of other combinations; also for a study comparing Teclistamab in combination with Daratumumab SC and Lenalidomide (Tec-DR) and Talquetamab in combination with Daratumumab SC and Lenalidomide (Tal-DR) vs. other comibnations.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Greg Bociek, MD,&nbsp;<\/strong>internal medicine-oncology\/hematology, received funding for a trial to evaluate the safety and efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) compared to chemoimmunotherapy in previously untreated follicular lymphoma.<\/li>\n\n\n\n<li><strong>Christopher D\u2019Angelo, MD,&nbsp;<\/strong>internal medicine-oncology\/hematology, received funding for a study to evaluate the safety and preliminary efficacy of BMS-986393 in novel combinations in patients with relapsed and\/or refractory multiple myeloma.<\/li>\n\n\n\n<li><strong>Mridula Krishnan, MBBS,&nbsp;<\/strong>internal medicine-oncology\/hematology, received funding for a study of the efficacy and safety of Adjuvant Autogene Cevumeran plus Atezolizumab and mFolfirinox versus mFolfirinox alone in patients with resected pancreatic ductal adenocarcinoma.<\/li>\n\n\n\n<li><strong>Steven Yeh, MD,<\/strong>&nbsp;ophthalmology and visual sciences, received funding for a study to investigate the safety and efficacy of oral Brepocitinib in adults with active, non-infectious intermediate-, posterior- and panuveitis.<\/li>\n\n\n\n<li><strong>Dr. Bailey-Lundberg <\/strong>also received funding for preclinical testing of pulse field ablation (pfa) for pancreatic adenocarcinoma.<\/li>\n\n\n\n<li><strong>Chittalsinh Raulji, MBBS,&nbsp;<\/strong>pediatrics-hematology\/oncology, received funding for a trial of DAY101 monotherapy vs. standard-of-care chemotherapy in patients with pediatric low-grade glioma harboring an activating RAF alteration requiring first-line systemic therapy; Dr. Raulji also received funding for a study investigating efficacy, safety and pharmacokinetics of concizumab prophylaxis in children below 12 years with haemophilia A or B with or without inhibitors.<\/li>\n\n\n\n<li><strong>Ruxana Sadikot, MD,<\/strong>&nbsp;internal medicine-pulmonary, received funding for a study to evaluate safety, pharmacokinetics and pharmacokinetic-pharmacodynamic relationships of RLS-0071 in patients with acute exacerbation of chronic obstructive pulmonary disease.<\/li>\n\n\n\n<li><strong>Laura Tenner, MD,&nbsp;<\/strong>internal medicine-oncology\/hematology, received funding for a study of perioperative Dostarlimab monotherapy vs. standard of care in participants with untreated T4N0 or Stage III dMMR\/MSI-H resectable colon cancer.<\/li>\n\n\n\n<li><strong>Hana Niebur, MD,&nbsp;<\/strong>pediatrics-allergy, received funding for a study evaluating the efficacy and safety of PT027 compared with PT007 administered as needed in participants 12 to &lt;18 years of age with asthma.<\/li>\n\n\n\n<li><strong>Melissa Muff-Luett, MD,&nbsp;<\/strong>pediatrics-nephrology, received funding for a study &#8211; US FDA 522 pediatric post market surveillance study.<\/li>\n\n\n\n<li><strong>Trevor Van Schooneveld, MD,<\/strong>&nbsp;internal medicine-infectious diseases, received funding for a study of the efficacy and safety of treatment with MNKD-101 (Clofazimine Inhalation Suspension) when added to guideline- based therapy.<\/li>\n\n\n\n<li><strong>Scott Koepsell, MD, PhD,<\/strong>&nbsp;pathology, microbiology and immunology, received funding for Alfa-evaluation HemosIL D-Dimer XLN, VTE sample collection.<\/li>\n\n\n\n<li><strong>Scott Campbell, MD, PhD,<\/strong>&nbsp;pathology, microbiology and immunology, received funding for Dataset of electronic health records for N3C clinical enclave according to the NCATS DUA.<\/li>\n\n\n\n<li><strong>Michael Lankhorst, MD,<\/strong>&nbsp;anesthesiology, received funding for \u201cSpinal cord stimulation for patients with painful diabetic neuropathy and peripheral arterial disease: mechanistic insights from a single-center, randomized, blinded, sham-controlled cross-over proof-of-concept trial.\u201d<\/li>\n\n\n\n<li><strong>Salehi Afshin, <\/strong>neurosurgery, received funding for an observational study on BK Medicals N20P6 (9007) transducer.<\/li>\n\n\n\n<li><strong>Jill Poole, MD,<\/strong>&nbsp;internal medicine-allergy\/immunology, received funding for the Atopic Status Across the USA Study.<\/li>\n\n\n\n<li><strong>Dr. Lunning <\/strong>also received funding for a study of UB-VV111 in combination with rapamycin in relapsed\/refractory (R\/R) CD19+ hematologic malignancies.<\/li>\n\n\n\n<li><strong>Dr. Desouza&nbsp;<\/strong>also received funding to study the efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg\/1.0 mg s.c. once weekly vs. tirzepatide 5 mg s.c. once weekly in participants with type 2 diabetes inadequately controlled.<\/li>\n\n\n\n<li><strong>Jingwei Xie, PhD,&nbsp;<\/strong>surgery-transplant, received funding for a student stipend.<\/li>\n<\/ul>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The college received grants\u00a0and awards representing more than $7 million in new funding in November. <\/p>\n","protected":false},"author":27,"featured_media":118570,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"65516,39566,40100,43114,52377,21118","_relevanssi_noindex_reason":"Yoast SEO Relevanssi index 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