{"id":120867,"date":"2024-11-01T16:21:48","date_gmt":"2024-11-01T21:21:48","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=120867"},"modified":"2025-03-28T16:34:04","modified_gmt":"2025-03-28T21:34:04","slug":"120867","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/120867\/","title":{"rendered":"Immunoscape"},"content":{"rendered":"
\n

Zachary Van Roy, an MD\/PhD trainee in the laboratory of Dr. Tammy Kielian, has indeed had a very productive month as he has published two first author manuscripts in Nature Communication and Cell Reports Medicine. The Cell Reports Medicine manuscript<\/a>, which he co-first authored with Drs. Gunjan Kak and Lee Korshoj, is the first to describe the immune landscape during craniotomy infections in patients.\u00a0 Transcriptional profiling revealed a strong Hypoxia-inducible factor 1a (HIF-1\u03b1) signature in patient samples.\u00a0 A \u201cbedside to bench\u201d approach was then used to demonstrate the importance of this pathway in a murine model of craniotomy infection.\u00a0 This conserved pathway may represent future therapeutic targets for craniotomy infection. Zach created this image characterizes the immune responses to a craniotomy infection, with leukocytes depicted as stars migrating towards the moon surface represented by a micro-CT model of a resected bone flap with surgical screw holes symbolizing craters. S. aureus<\/em> biofilm colonizes the moon surface, the predominant pathogen in infected patients. The image is overlayed with the HIF-1\u03b1 gene and the chemical structure of chetomin (HIF-1\u03b1 inhibitor) is a constellation.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

Zachary Van Roy, an MD\/PhD trainee in the laboratory of Dr. Tammy Kielian, has indeed had a very productive month as he has published two first author manuscripts in Nature Communication and Cell Reports Medicine. The Cell Reports Medicine manuscript, which he co-first authored with Drs. Gunjan Kak and Lee Korshoj, is the first to […]<\/p>\n","protected":false},"author":147,"featured_media":120855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[3263],"class_list":["post-120867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-research","department-pathology-and-microbiology","author_override-paul-fey-phd-unmc-department-of-pathology-microbiology-and-immunology"],"yoast_head":"\nImmunoscape<\/title>\n<meta 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