{"id":120882,"date":"2024-11-01T16:47:38","date_gmt":"2024-11-01T21:47:38","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=120882"},"modified":"2025-03-28T16:54:45","modified_gmt":"2025-03-28T21:54:45","slug":"dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/","title":{"rendered":"Dr. Angara receives UNMC Office of Post-Doctoral Training&#8217;s Excellence in Research Award"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>Dr. Rajendra Angara discovered a novel\u00a0<em>Coxiella<\/em>\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle contact sites between the host endoplasmic reticulum (ER) and lipid droplets (LDs).\u00a0<em>Cb<\/em>EPF1 contains two FFAT motifs, which are typically found in eukaryotic tether proteins that mediate ER-organelle contact sites. Using a combination of microscopy, live cell imaging, protein interaction assays, and mutagenesis, he demonstrated that\u00a0<em>Cb<\/em>EPF1\u2019s FFAT motifs are essential for establishing ER-LD contact sites and manipulating host LD metabolism. This study is the first to report a bacterial effector capable of inducing inter-organelle contact sites outside of bacteria-containing vacuole, providing a novel mechanism by which\u00a0<em>C. burnetii<\/em>\u00a0manipulates host cell metabolism. This discovery has extended our understanding of how pathogens hijack host cell inter-organelle communication and highlights possible potential therapeutic targets for intracellular bacterial infections.<\/p>\n\n\n\n<p>For this work, Dr. Angara accepted the award from Iqbal Ahmad, PhD, director of postdoctoral education, and chair of the UNMC Scientific Research Oversight Committee.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle contact sites between the host endoplasmic reticulum (ER) and lipid droplets (LDs).\u00a0CbEPF1 contains two FFAT motifs, which are typically found in eukaryotic tether proteins that mediate ER-organelle contact sites. Using a combination of microscopy, live cell [&hellip;]<\/p>\n","protected":false},"author":147,"featured_media":120883,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-120882","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","department-pathology-and-microbiology","author_override-paul-fey-phd-unmc-department-of-pathology-microbiology-and-immunology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dr. Angara receives UNMC Office of Post-Doctoral Training&#039;s Excellence in Research Award<\/title>\n<meta name=\"description\" content=\"Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Angara receives UNMC Office of Post-Doctoral Training&#039;s Excellence in Research Award\" \/>\n<meta property=\"og:description\" content=\"Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-01T21:47:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-28T21:54:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"407\" \/>\n\t<meta property=\"og:image:height\" content=\"368\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kirsten Stites\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@unmc\" \/>\n<meta name=\"twitter:site\" content=\"@unmc\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kirsten Stites\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\"},\"author\":{\"name\":\"Kirsten Stites\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8d60f7b72396aa43b51a9e39986dd455\"},\"headline\":\"Dr. Angara receives UNMC Office of Post-Doctoral Training&#8217;s Excellence in Research Award\",\"datePublished\":\"2024-11-01T21:47:38+00:00\",\"dateModified\":\"2025-03-28T21:54:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\"},\"wordCount\":177,\"publisher\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\",\"name\":\"Dr. Angara receives UNMC Office of Post-Doctoral Training's Excellence in Research Award\",\"isPartOf\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg\",\"datePublished\":\"2024-11-01T21:47:38+00:00\",\"dateModified\":\"2025-03-28T21:54:45+00:00\",\"description\":\"Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle\",\"breadcrumb\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg\",\"contentUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg\",\"width\":407,\"height\":368},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.unmc.edu\/newsroom\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dr. Angara receives UNMC Office of Post-Doctoral Training&#8217;s Excellence in Research Award\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#website\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/\",\"name\":\"Newsroom\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.unmc.edu\/newsroom\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#organization\",\"name\":\"University of Nebraska Medical Center\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png\",\"contentUrl\":\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png\",\"width\":500,\"height\":153,\"caption\":\"University of Nebraska Medical Center\"},\"image\":{\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/unmcedu\",\"https:\/\/x.com\/unmc\",\"https:\/\/instagram.com\/iamunmc\",\"https:\/\/www.youtube.com\/user\/UNMCEDU\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8d60f7b72396aa43b51a9e39986dd455\",\"name\":\"Kirsten Stites\",\"url\":\"https:\/\/www.unmc.edu\/newsroom\/author\/8d5e957f297893487bd98fa830fa6413\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dr. Angara receives UNMC Office of Post-Doctoral Training's Excellence in Research Award","description":"Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/","og_locale":"en_US","og_type":"article","og_title":"Dr. Angara receives UNMC Office of Post-Doctoral Training's Excellence in Research Award","og_description":"Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle","og_url":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/","og_site_name":"Newsroom","article_publisher":"https:\/\/www.facebook.com\/unmcedu","article_published_time":"2024-11-01T21:47:38+00:00","article_modified_time":"2025-03-28T21:54:45+00:00","og_image":[{"width":407,"height":368,"url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg","type":"image\/jpeg"}],"author":"Kirsten Stites","twitter_card":"summary_large_image","twitter_creator":"@unmc","twitter_site":"@unmc","twitter_misc":{"Written by":"Kirsten Stites","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#article","isPartOf":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/"},"author":{"name":"Kirsten Stites","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8d60f7b72396aa43b51a9e39986dd455"},"headline":"Dr. Angara receives UNMC Office of Post-Doctoral Training&#8217;s Excellence in Research Award","datePublished":"2024-11-01T21:47:38+00:00","dateModified":"2025-03-28T21:54:45+00:00","mainEntityOfPage":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/"},"wordCount":177,"publisher":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#organization"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/","url":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/","name":"Dr. Angara receives UNMC Office of Post-Doctoral Training's Excellence in Research Award","isPartOf":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage"},"thumbnailUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg","datePublished":"2024-11-01T21:47:38+00:00","dateModified":"2025-03-28T21:54:45+00:00","description":"Dr. Rajendra Angara discovered a novel\u00a0Coxiella\u00a0effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle","breadcrumb":{"@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#primaryimage","url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg","contentUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/03\/RajendraAngara.jpg","width":407,"height":368},{"@type":"BreadcrumbList","@id":"https:\/\/www.unmc.edu\/newsroom\/2024\/11\/01\/dr-angara-receives-unmc-office-of-post-doctoral-trainings-excellence-in-research-award\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.unmc.edu\/newsroom\/"},{"@type":"ListItem","position":2,"name":"Dr. Angara receives UNMC Office of Post-Doctoral Training&#8217;s Excellence in Research Award"}]},{"@type":"WebSite","@id":"https:\/\/www.unmc.edu\/newsroom\/#website","url":"https:\/\/www.unmc.edu\/newsroom\/","name":"Newsroom","description":"","publisher":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.unmc.edu\/newsroom\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.unmc.edu\/newsroom\/#organization","name":"University of Nebraska Medical Center","url":"https:\/\/www.unmc.edu\/newsroom\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/","url":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png","contentUrl":"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/overview-1.png","width":500,"height":153,"caption":"University of Nebraska Medical Center"},"image":{"@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/unmcedu","https:\/\/x.com\/unmc","https:\/\/instagram.com\/iamunmc","https:\/\/www.youtube.com\/user\/UNMCEDU"]},{"@type":"Person","@id":"https:\/\/www.unmc.edu\/newsroom\/#\/schema\/person\/8d60f7b72396aa43b51a9e39986dd455","name":"Kirsten Stites","url":"https:\/\/www.unmc.edu\/newsroom\/author\/8d5e957f297893487bd98fa830fa6413\/"}]}},"_links":{"self":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/120882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/users\/147"}],"replies":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/comments?post=120882"}],"version-history":[{"count":2,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/120882\/revisions"}],"predecessor-version":[{"id":120885,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/posts\/120882\/revisions\/120885"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/media\/120883"}],"wp:attachment":[{"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/media?parent=120882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/categories?post=120882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.unmc.edu\/newsroom\/wp-json\/wp\/v2\/tags?post=120882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}