{"id":121407,"date":"2025-04-16T09:30:00","date_gmt":"2025-04-16T14:30:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=121407"},"modified":"2025-04-15T12:00:35","modified_gmt":"2025-04-15T17:00:35","slug":"pathology-resident-researching-ways-to-detect-hypoglycemia-caused-by-pet-insulin","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2025\/04\/16\/pathology-resident-researching-ways-to-detect-hypoglycemia-caused-by-pet-insulin\/","title":{"rendered":"Pathology resident researching ways to detect hypoglycemia caused by pet insulin"},"content":{"rendered":"
\n

Some people bent on causing harm to themselves or others take insulin in a behavior known as factitious hypoglycemia. Medical professionals have developed tests to help uncover this, but a new area of concern has emerged: the use of insulin meant for pets.<\/p>\n\n\n\n

Kristina Sevcik, MD, a second-year anatomic and clinical pathology resident in UNMC\u2019s Department of Pathology, Microbiology and Immunology, and her faculty mentor, Ria C. Fyffe-Freil, PhD, are studying ways to detect pet insulin in human patients. It\u2019s cheaper and easier to obtain pet insulin, making it ripe for abuse. That\u2019s why their study of the effectiveness of three different immunoassay platforms and their four different assay formulations is so important, Dr. Sevcik said.<\/p>\n\n\n\n

Her study is made possible by the department\u2019s Research Grant Awards, created in 2024. The awards provide up to $10,000 in research funding to residents and fellows. The aim of this program is to advance the experience and mentorship in clinical and translational research.<\/p>\n\n\n\n

\u201cWe\u2019re trying to contribute to that aspect of the literature\u2014if someone has access to these medications, what would that look like on our labs? How can we work that up? The different detection systems all pick things up differently,\u201d Dr. Sevcik said.<\/p>\n\n\n\n

She said their study involves spiking normal serum samples collected at UNMC with two of the most common pet insulins in varying concentrations. The samples will be analyzed in-house and then sent to two external labs that employ different chemical assay systems.<\/p>\n\n\n\n

\u201cWe\u2019re trying to characterize how these different systems pick up different types of insulin and create a profile,\u201d she said. \u201cSo if you have a concern someday that this patient\u2019s hypoglycemia isn\u2019t making sense, where can we send these samples to see if there\u2019s inconsistencies that follow the pattern we\u2019re detecting?\u201d<\/p>\n\n\n\n

Dr. Fyffe-Freil said that analytically, it can be a challenge to detect different forms of synthetic and\/or natural insulin derivatives.<\/p>\n\n\n\n

\u201cIn both forensic and overdose settings, it is crucial to identify the origins of any elevated insulin concentrations,\u201d she said. \u201cI have experience with several cases of just this: a patient with critically high insulin levels in their blood with no apparent source. Once insulin-secreting tumors are ruled out, then it becomes an episode of Forensic Files: scrambling to identify the source to prevent further harm.<\/p>\n\n\n\n

\u201cNot all clinical insulin assays are created equal, either\u2014each one exhibits different specificities for the different insulin analogs, so often it becomes a process of elimination by running the patient’s sample on multiple assays to narrow down the type of insulin,\u201d Dr. Fyffe-Freil said. \u201cDr. Sevcik’s work will fill an important gap in the literature, serving to guide laboratorians through this challenging analysis in the future.\u201d<\/p>\n

gDvy zR<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Some people bent on causing harm to themselves or others take insulin in a behavior known as factitious hypoglycemia. Medical professionals have developed tests to help uncover this, but a new area of concern has emerged: the use of insulin meant for pets. Kristina Sevcik, MD, a second-year anatomic and clinical pathology resident in UNMC\u2019s […]<\/p>\n","protected":false},"author":146,"featured_media":121408,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[3559,3558,3560,3263],"class_list":["post-121407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-factitious-hypoglycemia","tag-hypoglycemia","tag-pet-insulin","tag-research","department-pathology-and-microbiology","author_override-duane-retzlaff-unmc-department-of-pathology-microbiology-and-immunology"],"yoast_head":"\nPathology resident researching hypoglycemia caused by pet insulin<\/title>\n<meta name=\"description\" content=\"Some people bent on causing harm to themselves or others take insulin in a behavior known as factitious hypoglycemia. 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