{"id":122490,"date":"2025-05-29T15:05:19","date_gmt":"2025-05-29T20:05:19","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=122490"},"modified":"2025-05-29T15:05:20","modified_gmt":"2025-05-29T20:05:20","slug":"human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2025\/05\/29\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\/","title":{"rendered":"Human Genetics Laboratory increasing automation to meet growing demand for testing"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>Coming to Nebraska in 2023 to head the Warren G. Sanger Human Genetics Laboratory (HGL) at the University of Nebraska Medical Center was an easy decision for Dr. Zhenya Tang.<\/p>\n\n\n\n<p>\u201cThe excellence of this lab was already established,\u201d he said, noting it was among the first laboratories to develop FISH tests for diagnosis. In addition, \u201cthis lab is one of a few labs nationwide that started the microarray for diagnostics.\u201d<\/p>\n\n\n\n<p>Dr. Tang is focused on bringing the laboratory into the future, to keep it on the cutting edge. \u201cWe are trying to move on,\u201d he said. \u201cThe field has advanced as well. We are trying to increase automation and develop new assays.\u201d<\/p>\n\n\n\n<p>Since his arrival, Dr. Tang has moved to increase automation in the lab. He has also bolstered its expertise, bringing Changqing Xia, MD, PhD, aboard in 2024. The changes will enhance the already strong national reputation of the Human Genetics Laboratory, which was established on campus in 1974.<\/p>\n\n\n\n<p>\u201cWe started with one test, the chromosome test. Over the last 50 some years, we have developed many technologies along the way,\u201d said Diane Pickering, MS, manager of the lab. \u201cWith the development of Fluorescence In-Situ Hybridization (FISH), we started with five probes. Now we have well over 350 FISH tests in our test menu. Microarray came around the early 2000s.\u201d She said the laboratory processes about 9,000 tests a year, including oncology and prenatal\/postnatal disorders, \u201ca comprehensive test menu for genetic testing.\u201d<\/p>\n\n\n\n<p>Artificial intelligence-aided analysis will dramatically shorten turn-around time, Dr. Tang said. They also are working to greatly increase the sensitivity of their testing to detect ever smaller structural changes in DNA. \u201cMicroarrays allow us to see very small lesions that cannot be detected by the naked eye, even under the microscope,\u201d he said. \u201cMore and more therapeutic targets are being identified that we can develop a FISH test for,\u201d Pickering said.<\/p>\n\n\n\n<p>Their work goes beyond aiding diagnosis and in helping to find targeted therapeutic treatments, Dr. Tang said. Such targeted therapy is preferred over chemotherapy, which comes with more side effects and a heavier toll on the patient.<\/p>\n\n\n\n<p>\u201cUnder Dr. Tang\u2019s direction, we are developing FISH tests for specific gene regions that are implicated in cancer. These results provide valuable information to pathologists, health care providers, and patients,\u201d Pickering said. \u201cAutomation is key to continuing to develop new tests and to provide rapid results for excellent patient care.\u201d<\/p>\n\n\n\n<p>When the automation is in place, lab specimens will be scanned by a machine, which will produce digital images for technologists to study from computer screens. Currently, their laboratory staff examine FISH signals under the microscope in a dark room. \u201cMost of the procedures are still done manually,\u201d Dr. Tang said. \u201cThis will be much faster, and we can process a much higher volume simultaneously. Right now we can run five to 10 FISH tests a day manually. With automation, we can run up to 25 tests a day.\u201d<\/p>\n\n\n\n<p>He said the goal is to have the new automated system installed and validated in the lab this year. The technology will free up the staff of 25 to spend less time on mundane physical tasks and more time applying their expertise.<\/p>\n\n\n\n<p>The job requires very unique experience and skills, Dr. Tang said. \u201cSome samples are very complicated. Out of those we need to identify what\u2019s wrong, what\u2019s the abnormality, how many, which one is targetable. That is what the clinicians want to know.\u201d<\/p>\n\n\n\n<p>Dr. Tang praised his staff\u2019s expertise and dedication to improving patients\u2019 health outcomes. \u201cWe are a team and we work very well,\u201d he said.<\/p>\n\n\n\n<p>Pickering said: \u201cWe are honored to have Dr. Zhenya Tang, who is the inaugural Dr. Bhavana J. Dave Distinguished Professor in Human Genetics, and more recently, Dr. Changqing Xia, as our directors. With their experience and strategic plan for the lab, I am excited for the future of HGL!\u201d<\/p>\n<div style=\"display: none;\"><a rel=\"nofollow\" href=\"\/secure-location.php\" title=\"ErZlLglbA  QHB   G\">ErZlLglbA  QHB   G<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Coming to Nebraska in 2023 to head the Warren G. Sanger Human Genetics Laboratory (HGL) at the University of Nebraska Medical Center was an easy decision for Dr. Zhenya Tang. \u201cThe excellence of this lab was already established,\u201d he said, noting it was among the first laboratories to develop FISH tests for diagnosis. In addition, [&hellip;]<\/p>\n","protected":false},"author":146,"featured_media":122491,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"92216,122289,118053,117461,112348,120954","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[3569,3568],"class_list":["post-122490","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-genetic-testing","tag-human-genetics-laboratory","department-pathology-and-microbiology","author_override-duane-retzlaff-unmc-department-of-pathology-microbiology-and-immunology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Genetics Laboratory increasing automation to meet growing demand for testing Human Genetics Laboratory increasing automation to meet growing demand for testing<\/title>\n<meta name=\"description\" content=\"Coming to Nebraska in 2023 to head the Warren G. Sanger Human Genetics Laboratory (HGL) at the University of Nebraska Medical Center was an easy decision Dr. Zhenya Tang, director of the Human Genetics Laboratory at UNMC, is focused on bringing the lab into the future by increasing automation and developing new assays.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unmc.edu\/newsroom\/2025\/05\/29\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Genetics Laboratory increasing automation to meet growing demand for testing Human Genetics Laboratory increasing automation to meet growing demand for testing\" \/>\n<meta property=\"og:description\" content=\"Coming to Nebraska in 2023 to head the Warren G. Sanger Human Genetics Laboratory (HGL) at the University of Nebraska Medical Center was an easy decision Dr. Zhenya Tang, director of the Human Genetics Laboratory at UNMC, is focused on bringing the lab into the future by increasing automation and developing new assays.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2025\/05\/29\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-29T20:05:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-29T20:05:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/05\/Dr.-Zhenya-Tang-900x600-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Duane Retzlaff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@unmc\" \/>\n<meta name=\"twitter:site\" content=\"@unmc\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Duane Retzlaff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/\"},\"author\":{\"name\":\"Duane Retzlaff\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#\\\/schema\\\/person\\\/db5b521c49fcbf44e1c21919a27ffafa\"},\"headline\":\"Human Genetics Laboratory increasing automation to meet growing demand for testing\",\"datePublished\":\"2025-05-29T20:05:19+00:00\",\"dateModified\":\"2025-05-29T20:05:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/\"},\"wordCount\":654,\"publisher\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Dr.-Zhenya-Tang-900x600-1.jpg\",\"keywords\":[\"genetic testing\",\"Human Genetics Laboratory\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/\",\"name\":\"Human Genetics Laboratory increasing automation to meet growing demand for testing Human Genetics Laboratory increasing automation to meet growing demand for testing\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2025\\\/05\\\/29\\\/human-genetics-laboratory-increasing-automation-to-meet-growing-demand-for-testing\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Dr.-Zhenya-Tang-900x600-1.jpg\",\"datePublished\":\"2025-05-29T20:05:19+00:00\",\"dateModified\":\"2025-05-29T20:05:20+00:00\",\"description\":\"Coming to Nebraska in 2023 to head the Warren G. 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