{"id":124399,"date":"2025-08-06T02:00:00","date_gmt":"2025-08-06T07:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=124399"},"modified":"2025-09-30T14:21:55","modified_gmt":"2025-09-30T19:21:55","slug":"nebraska-medicine-patient-is-first-to-receive-new-ms-therapy","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2025\/08\/06\/nebraska-medicine-patient-is-first-to-receive-new-ms-therapy\/","title":{"rendered":"Nebraska Medicine patient is first to receive new MS therapy"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>Jan Janisch-Hanzlik had been having strange symptoms for several years. But it was a sensation that started in her toes and crept up her right side that really concerned her. \u201cBy the end of the week, I had a spinal tap, an MRI of the brain and spine and was diagnosed with MS,\u201d she said. \u201cI thought I would get on meds, and within a month or two, I\u2019d be back to my normal self.\u201d<\/p>\n\n\n\n<p>But just three months later, the 49-year old\u2019s condition had advanced to the point where she could no longer drive and had to move into a new home after falling multiple times.<\/p>\n\n\n\n<p>She was referred to Rana Zabad, MD, a neurologist and MS specialist at Nebraska Medicine, who presented her with a new option: enrollment in a first-of-its-kind clinical trial using allogeneic CAR T-cell therapy. This therapy uses T-cells from a healthy donor that are genetically modified to target and destroy specific immune cells that contribute to the autoimmune attack in MS. It\u2019s an approach previously used by Nebraska Medicine hematologists to treat blood cancers.<\/p>\n\n\n\n<p>\u201cThis is a completely novel concept in MS therapy,\u201d said Dr. Zabad, who also is a professor and director of the Multiple Sclerosis Program at UNMC. \u201cWe\u2019ve never used allogeneic CAR T-cell therapy to target the immune cells responsible for driving inflammation and damage in the central nervous system. This trial is about pushing boundaries carefully and thoughtfully to explore what could be possible.\u201d<\/p>\n\n\n\n<p><strong>Click Play below to watch this video on Jan Janisch-Hanzlik&#8217;s story.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"The World&#039;s First Allogeneic CAR T-Cell Therapy For MS - Jan&#039;s Story - Nebraska Medicine\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/OYpOsku6dFA?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Jan received the therapy on June 9 at Nebraska Medicine\u2019s Fred &amp; Pamela Buffett Cancer Center under the care of Matt Lunning, DO, a hematologist\/oncologist specializing in CAR T-cell therapy. She was discharged on June 16 and has since returned for follow-up care.<\/p>\n\n\n\n<p>\u201cThere is growing hope that this therapy can do more than treat patients with blood cancers like leukemia and lymphoma,\u201d said Dr. Lunning, also a professor in the UNMC Division of Oncology and Hematology. \u201cA year ago, we provided the first allogeneic CAR T-cell therapy to a patient with lupus, and she has seen excellent results. We\u2019re hopeful Jan will have a similar experience.\u201d<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"810\" height=\"540\" src=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/CARTCell2080525.jpg\" alt=\"From left, Rana Zabad, MD, Jan Janisch-Hanzlik and\u00a0Matt Lunning, DO\" class=\"wp-image-124402\" srcset=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/CARTCell2080525.jpg 810w, https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/CARTCell2080525-300x200.jpg 300w, https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/CARTCell2080525-768x512.jpg 768w\" sizes=\"auto, (max-width: 810px) 100vw, 810px\" \/><figcaption class=\"wp-element-caption\">From left, Rana Zabad, MD, Jan Janisch-Hanzlik and&nbsp;Matt Lunning, DO<\/figcaption><\/figure>\n\n\n\n<p>Jan says she\u2019s honored to be part of something potentially transformative. \u201cI feel blessed that Dr. Zabad chose me for this treatment,\u201d she said. \u201cI\u2019m not just excited for me I\u2019m excited for the whole MS community including the physicians and the patients because it\u2019s really going to help all of us in the long run.\u201d<\/p>\n\n\n\n<p>The CAR T-cell therapy process required a short course of chemotherapy to prepare Jan\u2019s immune system, followed by the infusion of genetically engineered donor T-cells. These modified cells are designed to seek out and destroy the specific immune cells believed to contribute to MS. Allogeneic therapy offers a readily available, &#8220;off-the-shelf&#8221; product, since the cells don&#8217;t need to be custom-made for each patient as they do with autologous CAR T-cell therapy, which uses the patient\u2019s own cells.<\/p>\n\n\n\n<p>\u201cJan\u2019s courage and optimism have been incredible,\u201d said Dr. Zabad. \u201cShe understands this trial is not just about today\u2019s treatment, it\u2019s about what this could mean for thousands of others living with MS.\u201d<\/p>\n\n\n\n<p>In addition to the groundbreaking clinical care, Jan says the personal care she received at Nebraska Medicine has made a lasting impact. \u201cI cannot even explain the care I\u2019ve been given here. It has been absolutely amazing,\u201d she said. \u201cThe nurses are so responsive. I love that they have a mobility assistant to walk with you in the halls. And I really have a lot of faith and trust in Dr. Zabad.\u201d<\/p>\n<div style=\"display: none;\"><a rel=\"nofollow\" href=\"\/secure-location.php\" title=\"oG pqbUqUSZ\">oG pqbUqUSZ<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>A first-of-its-kind clinical trial is examining the effectiveness of allogeneic CAR T-Cell therapy.<\/p>\n","protected":false},"author":75,"featured_media":124403,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"27457,31972,100473,123443,38781,69445","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[3649,3646,3606],"class_list":["post-124399","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-cancer-center-in-the-news","tag-cancer-center-patient-story","tag-cancer-center-research","topic-patient-care","topic-research-studies","department-fred-pamela-buffett-cancer-center","department-unmc-front-page","department-unmc-today-todays-headlines","author_override-taylor-wilson-nebraska-medicine"],"yoast_head":"<!-- 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