{"id":125006,"date":"2025-09-12T22:31:44","date_gmt":"2025-09-13T03:31:44","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=125006"},"modified":"2025-09-12T22:31:46","modified_gmt":"2025-09-13T03:31:46","slug":"can-a-diabetes-drug-prevent-osteoarthritis-after-acl-tear","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2025\/09\/12\/can-a-diabetes-drug-prevent-osteoarthritis-after-acl-tear\/","title":{"rendered":"Can a Diabetes Drug Prevent Osteoarthritis After ACL Tear?"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p>A groundbreaking national research study is exploring whether a common diabetes medication, metformin, could prevent osteoarthritis (OA) in patients recovering from anterior cruciate ligament (ACL) tears. OA is the most common form of arthritis and a leading cause of disability, often developing after knee injuries.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.unmc.edu\/orthosurgery\/faculty\/tao.html\">Dr. Matthew Tao<\/a>, an orthopaedic surgeon, highlights the risk: \u201cAt 10 years post-injury, about 50% of people show signs of osteoarthritis on X-rays. By 20 years, it jumps to 70%.\u201d Alarmingly, ACL injuries leave individuals aged 30-39 up to 20 times more likely to require knee replacements than their peers.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"450\" src=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/Tao_Newsletter_Web.jpg\" alt=\"Matthew A. Tao, MD\" class=\"wp-image-125007\" style=\"width:234px;height:auto\" srcset=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/Tao_Newsletter_Web.jpg 300w, https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2025\/08\/Tao_Newsletter_Web-200x300.jpg 200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"wp-element-caption\">Matthew A. Tao, MD<\/figcaption><\/figure>\n<\/div>\n\n\n<p>The Preventing Injured Knees from osteoArthritis: Severity Outcomes (PIKASO) trial, led by top researchers from nine institutions, aims to determine whether metformin can reduce knee inflammation and slow cartilage degradation following ACL reconstruction. Co-principal investigators Dr. Liz Wellsandt and Dr. Yvonne Golightly from the University of Nebraska Medical Center (UNMC) are spearheading this effort locally.<\/p>\n\n\n\n<p>\u201cMetformin has shown promise in reducing inflammation in previous studies, particularly in people with obesity and knee osteoarthritis,\u201d says Dr. Wellsandt. \u201cThe PIKASO study is the first to test its effects following an ACL injury.\u201d<\/p>\n\n\n\n<p>This randomized, double-blind clinical trial assigns participants to take either metformin or a placebo daily for one year. Researchers will monitor knee pain and early OA signs using MRI scans over two years.<\/p>\n\n\n\n<p>Dr. Tao notes the transformative potential of this study: \u201cIf successful, metformin could revolutionize sports medicine by offering an easy, safe solution to a major long-term problem.\u201d<\/p>\n\n\n\n<p>Enrollment is open at UNMC for individuals aged 19 to 45, with the trial expected to conclude in 2028. If proven effective, metformin could significantly improve post-injury knee health and quality of life for patients.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Dr. Matthew Tao is participating in the Preventing Injured Knees from osteoArthritis: Severity Outcomes (PIKASO) trial, a study designed to answer that very question.<\/p>\n","protected":false},"author":151,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-125006","post","type-post","status-publish","format-standard","hentry","category-uncategorized","author_override-unmc-department-of-orthopaedic-surgery-and-rehabilitation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can a Diabetes Drug Prevent Osteoarthritis After ACL 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