{"id":125289,"date":"2025-09-02T12:41:11","date_gmt":"2025-09-02T17:41:11","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=125289"},"modified":"2025-09-24T11:29:43","modified_gmt":"2025-09-24T16:29:43","slug":"lieberman-grant-fuels-study-on-cannabis-use-hiv-and-brain-aging","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2025\/09\/02\/lieberman-grant-fuels-study-on-cannabis-use-hiv-and-brain-aging\/","title":{"rendered":"Lieberman grant fuels study on cannabis use, HIV and brain aging"},"content":{"rendered":"
\n

Biju Bhargavan, PhD, a researcher with the UNMC Department of Anesthesiology, is exploring how chronic cannabis use may affect the aging brain in people living with HIV (PLWH), thanks to support from a Lieberman Research Pilot Grant.<\/p>\n\n\n\n

Dr. Bhargavan, a faculty member with a background in neurovirology, is using the pilot funding to launch his first independently funded project, a milestone that marks a major step forward in his academic career.<\/p>\n\n\n\n

\u201cThis award validates the direction of my research and provides the momentum to translate ideas into actionable science,\u201d Dr. Bhargavan said. \u201cIt\u2019s an important step toward establishing myself as a principal investigator.\u201d<\/p>\n\n\n\n

The project examines whether long-term cannabis use, often adopted by people living with HIV to manage symptoms such as pain, anxiety or sleep disturbances, may actually accelerate central nervous system aging. While some studies have suggested cannabis may have neuroprotective or anti-inflammatory effects, others link it to cognitive impairment and psychiatric side effects. Dr. Bhargavan aims to uncover the biological mechanisms that may explain these conflicting outcomes.<\/p>\n\n\n\n

\u201cThere\u2019s a significant gap in our understanding of how chronic cannabis exposure affects aging in the HIV-infected brain,\u201d he said. \u201cOur hypothesis is that it accelerates cerebrovascular aging, particularly with prolonged exposure to CBD- or THC-dominant formulations.\u201d<\/p>\n\n\n\n

To test this, the research team will use animal models to assess how cannabinoids influence neuroinflammation, stress and cellular senescence, key drivers of aging-related brain changes.<\/p>\n\n\n\n

Dr. Bhargavan said the findings could help inform clinical guidance and harm reduction strategies for patients with HIV who use cannabis. \u201cIf cannabis worsens aging-related brain stress in this population, it\u2019s critical that patients and providers understand those risks.\u201d<\/p>\n\n\n\n

This work builds on Dr. Bhargavan\u2019s broader research interests in central nervous system aging, blood-brain barrier dysfunction and the long-term neurological effects of HIV. \u201cCannabis use is a growing and often overlooked factor,\u201d he said. \u201cThere\u2019s no direct evidence yet on how it contributes to aging in the context of HIV. That\u2019s what we\u2019re trying to change.\u201d<\/p>\n\n\n\n

If early results are promising, Dr. Bhargavan plans to pursue NIH funding to expand the research.<\/p>\n\n\n\n

For early-career scientists, the Lieberman Award is more than just financial support, it\u2019s a catalyst for growth. Dr. Bhargavan credits his mentor, Georgette Kanmogne, PhD, for helping shape a successful proposal. \u201cHer insight and encouragement were absolutely pivotal,\u201d he said.<\/p>\n\n\n\n

He encourages others to apply for pilot funding with focused, realistic projects that build on their expertise. \u201cPilot funding is the lifeblood of early-stage research. It allows investigators to take risks, generate proof-of-concept data, and develop novel ideas that might otherwise never see the light of day. It\u2019s the first spark that can lead to meaningful scientific and clinical advances.\u201d<\/p>\n

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