{"id":129734,"date":"2026-02-10T09:30:00","date_gmt":"2026-02-10T15:30:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=129734"},"modified":"2026-02-10T10:15:59","modified_gmt":"2026-02-10T16:15:59","slug":"dr-larson-wraps-up-career-in-scientific-research","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2026\/02\/10\/dr-larson-wraps-up-career-in-scientific-research\/","title":{"rendered":"Dr. Larson wraps up career in scientific research"},"content":{"rendered":"
\n

Marilynn Larson absolutely loves scientific research. It\u2019s what got her through a daily commute between Lincoln and Omaha during her 26 years at the University of Nebraska Medical Center. Sometimes sleeping on a cot in her office when she had to get up in the middle of the night for timed experiments, putting on all the protective gear to work in the Biosafety Level 3 Core Facility.<\/p>\n\n\n\n

\u201cI love, I love the research part. I love the challenge. I love doing infectious disease research, I like doing cutting edge. The resources here are outstanding,\u201d she said. \u201cBut the people here\u2014I think that\u2019s why I love working here the most. Just a lot of good people, a lot of colleagues that are very dear friends that I felt I could go talk to and ask questions. Even though I was kind of all alone in my field.\u201d<\/p>\n\n\n\n

That field being select agent pathogens, specifically Francisella tularensis, a hypervirulent Tier 1 select agent that is fatal if not promptly treated. In her time at UNMC, Dr. Larson was lead author or co-author on numerous papers on Francisella tularensis, said Dr. Paul Fey, a professor and vice-chair of research for the department. \u201cSome really great work, so many great things you\u2019ve done here,\u201d he said at Dr. Larson\u2019s retirement reception on Jan. 29.<\/p>\n\n\n\n

Dr. Pete Iwen, a department professor and director of the Nebraska Public Health Laboratory, said she is internationally recognized as an authority on the hypervirulent Tier 1 select agent. For all her many contributions to the field, \u201cThank you, Marilynn,\u201d he said.<\/p>\n\n\n\n

Dr. Larson said she is proud of her work as laboratory director for the BSL-3 core facility. She helped get it set up in 2020 and oversaw the associated record keeping\/documentation and personnel training at the beginning of the COVID-19 pandemic for UNMC researchers to study this highly infectious virus. She also assisted with the recent upgrades to the facility.<\/p>\n\n\n\n

She also developed a more accurate identification method for Francisella tularensis. \u201cThe CDC\u2019s assay for Francisella tularensis wasn\u2019t specific enough\u2014there\u2019s a near neighbor strain that isn\u2019t pathogenic, it\u2019s more opportunistic, so their assay wouldn\u2019t differentiate between them. So I published it, I also got a patent for it, but I\u2019m not going to continue the patent because I\u2019m not rich enough to continue a patent, and I want people to use it. But I think the CDC has incorporated that into their new assay so it can differentiate the different subtypes of Francisella tularensis, the different pathogenicity, with one being the one of the most pathogenic bacteria known.\u201d<\/p>\n\n\n\n

Dr. Larson also served on the faculty of the UNMC Immunology, Pathology and Infectious Disease (IPID) Graduate Program, and as a fellow in the National Strategic Research Institute of Nebraska. She provided guidance on select agent procedures and regulatory compliance matters required by the Centers for Disease Control and Prevention and assisted with biological select agent and toxin associated projects for the Department of Defense. She is a member of the High Containment Working Group and Biosafety and Incident Command Committee.<\/p>\n\n\n\n

Her scientific journey began at the University of Nebraska\u2013Lincoln, where she changed majors a few times before getting a BS in general sciences. \u201cI was fascinated by the sciences\u2014it didn\u2019t matter what it was: astronomy, organic chemistry, physics, I was just fascinated.\u201d She then worked in private industry but found it boring and headed back to school, earning her MS in molecular biology from the University of Nebraska at Omaha and later, her PhD in biological sciences at UNL.<\/p>\n\n\n\n

\u201cAfter that, I was offered a fellowship in virology in Lincoln. But instead I chose a job here because I wanted to do biomedical research with Dr. Tom McDonald in immunology.\u201d<\/p>\n\n\n

\n
\"\"
Dr. Paul Fey with Dr. Larson at her retirement reception.<\/figcaption><\/figure>\n<\/div>\n\n\n

She started at UNMC in 2000 as a postdoctoral student, then joined the faculty a year later as an instructor. She said Dr. Fey mentioned that Dr. Steven Hinrichs, who went on to become the department chair, needed help with his research. \u201cIt was a great experience,\u201d she said. \u201cHe\u2019s a great mentor. He did a lot of work with biological select agents and toxins. That\u2019s where I got all that experience working with BSL-3 select agents. We did a lot of projects for the DOD. He mentored me to make me more independent. He taught me all this financial stuff. That was like a black hole for me at first.\u201d She was promoted to assistant professor in 2007.<\/p>\n\n\n\n

\u201cPete Iwen has been an awesome mentor, too,\u201d she said. \u201cHe kind of pushed me toward Francisella tularensis, because they get a lot of cases of tularemia here in the Midwest. It\u2019s one of the most pathogenic bacteria known, and we have the most pathogenic subtype here in the Midwest. It\u2019s pretty nasty,\u201d requiring research in the BSL-3, wearing PPE. \u201cYou have to wear a gown, shoe covers, double gloves, respiratory protection. It\u2019s quite cumbersome and it\u2019s time-consuming. I\u2019d say working with a select agent probably takes you 10 times longer than working with something like staph or E. coli,\u201d she said.<\/p>\n\n\n\n

\u201cIt\u2019s very slow. I\u2019m not really a patient person, so why I went into research, I don\u2019t know. I think I like the challenge; I like the troubleshooting. I like trying to figure things out.\u201d<\/p>\n\n\n\n

Despite the challenges and frustrations, Dr. Larson said she wouldn\u2019t change a thing\u2014besides the hassle of commuting. \u201cI don\u2019t regret it, because it\u2019s been the best thing ever for me. I didn\u2019t know if I would ever find a job I would like after all those other jobs and situations, but I\u2019ve just loved working here. It’s been a great, great time. When you reach a certain age, people keep asking when are you going to retire, when are you going to retire? Because they don\u2019t like their job. And I\u2019m thinking man, I\u2019ve been so blessed. I love my job, I don\u2019t want to retire. But yet you slow down. I lost my oldest brother last year to cancer and I wanted to go see him, but I didn\u2019t. You can\u2019t put that stuff off. It puts it in perspective. I want to spend more time with family and friends before they\u2019re gone, or I\u2019m gone.\u201d<\/p>\n\n\n\n

Dr. Larson plans to volunteer with the Boys and Girls Club of Lincoln-Lancaster County. \u201cI\u2019ll try to get these junior high kids and high school kids interested in science,\u201d she said, and do other volunteer work that she didn\u2019t have time for before. She\u2019s also looking forward to exercising more regularly and having more time to garden and make art.<\/p>\n\n\n\n

But first, a road trip with her significant other, Richard Conrad, a retired Lincoln high school teacher. \u201cWe\u2019re going to head west, go up the coast, take Highway 101 and pick up Richard\u2019s brother and girlfriend and bring them back for Richard\u2019s 94-year-old mother\u2019s birthday.\u201d<\/p>\n\n\n\n

This kind of driving she doesn\u2019t mind. \u201cWe\u2019ll get to stop whenever we want. If there\u2019s traffic and we don\u2019t want to deal with it, we\u2019ll just pull over someplace interesting and check it out.\u201d<\/p>\n<\/a><\/div><\/div>","protected":false},"excerpt":{"rendered":"

Marilynn Larson absolutely loves scientific research. It\u2019s what got her through a daily commute between Lincoln and Omaha during her 26 years at the University of Nebraska Medical Center. Sometimes sleeping on a cot in her office when she had to get up in the middle of the night for timed experiments, putting on all the protective gear to work in the Biosafety Level 3 Core Facility. \u201cI love, I love the research part. I love the challenge,\u201d she said. <\/p>\n","protected":false},"author":146,"featured_media":129736,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[3731,3263,3732],"class_list":["post-129734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-pathology-faculty","tag-research","tag-select-agent-pathogens","department-pathology-and-microbiology","author_override-duane-retzlaff-unmc-department-of-pathology-microbiology-and-immunology"],"yoast_head":"\nDr. Larson wraps up career in scientific research<\/title>\n<meta name=\"description\" content=\"Marilynn Larson absolutely loves scientific research. 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