{"id":136150,"date":"2026-10-14T01:56:00","date_gmt":"2026-10-14T06:56:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/?p=136150"},"modified":"2026-10-13T07:18:02","modified_gmt":"2026-10-13T12:18:02","slug":"mother-participates-in-cancer-trial-to-help-future-generations","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2026\/10\/14\/mother-participates-in-cancer-trial-to-help-future-generations\/","title":{"rendered":"Mother participates in cancer trial to help &#8216;future generations&#8217;"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p class=\"wp-block-paragraph\">Brandi Muhle said yes to a clinical trial that meant exploring a new way to reduce ovarian cancer risk \u2013 one that could potentially delay menopause for women like her.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Muhle is a participant in the SOROCk trial in Omaha, at the NCI-designated Fred &amp; Pamela Buffett Cancer Center. This national study is investigating whether removing just the fallopian tubes while delaying removal of the ovaries can reduce the risk of ovarian cancer similarly to removing both the ovaries and fallopian tubes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For Muhle, this choice was very personal.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI know what it means to live with an inherited cancer risk,\u201d she said. \u201cI lost my mom to breast cancer.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Muhle found out at 19 that she has a BRCA gene mutation, which raises her risk for some cancers. When she was 22, she had a mastectomy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI am a mother to a four-month-old daughter, and I feel strongly about doing everything I can to lower my own risk and help create better options for my daughter and future generations,\u201d she says.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For women with a high inherited risk of ovarian cancer, one way to lower the risk is to remove both the ovaries and fallopian tubes. However, taking out the ovaries causes immediate surgical menopause.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That was a major consideration for Muhle.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cGoing into menopause at 35 really worried me,\u201d she said. \u201cThere are many things to think about, like mental health, bone strength, heart health, and other changes in the body. It\u2019s not just about removing the ovaries; it\u2019s a big thing.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The SOROCk trial is based on a discovery that changed how researchers understand where most high-grade serous ovarian cancers begin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWe have discovered that the vast majority of ovarian cancers actually start in the fallopian tubes,\u201d said Kerry Rodabaugh, MD, gynecologic oncologist and principal investigator of the SOROCk Trial. \u201cWith this trial, we are also looking at how participants in the study feel about their quality of life with delaying surgical menopause.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The SOROCk approach is different from opportunistic salpingectomy, where doctors might remove the fallopian tubes during another surgery, such as a C-section, after childbearing.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the trial, Dr. Rodabaugh, the McClure L. Smith Professor of Gynecologic Oncology at UNMC, is studying risk-reducing salpingectomy as a strategy for women at high risk of ovarian cancer, often because they have a known genetic mutation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ovarian cancer can be particularly difficult to detect early.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cEarly cancer often does not cause symptoms,\u201d Dr. Rodabaugh said. \u201cWhen symptoms do occur, they can be nonspecific and are often thought to be related to the gastrointestinal tract.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Rodabaugh said that routine monitoring also does not always detect cancer in the early stage.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cI have had patients in my practice who had routine exams and ultrasounds with normal results but returned months later with advanced ovarian cancer,&#8221; she said.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is a difficult cancer to detect at an early stage.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cFor patients like Brandi, that uncertainty makes prevention especially important. But prevention can also come with difficult choices,\u201d Dr. Rodabaugh said. \u201cThe possibility of reducing ovarian cancer risk without requiring women to enter surgical menopause immediately is what makes the study important.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cA total sense of peace of mind,\u201d Muhle said.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Being part of the trial has given her something equally important: reassurance that she can take steps to reduce her risk.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Brandi Muhle is taking part in the SOROCk trial, which explores a way to reduce ovarian cancer risk. 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