{"id":32437,"date":"2008-06-18T00:00:00","date_gmt":"2008-06-18T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2008\/06\/18\/new-compounds-may-treat-ocular-neurodegenerative-disorders\/"},"modified":"2008-06-18T00:00:00","modified_gmt":"2008-06-18T05:00:00","slug":"new-compounds-may-treat-ocular-neurodegenerative-disorders","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2008\/06\/18\/new-compounds-may-treat-ocular-neurodegenerative-disorders\/","title":{"rendered":"New compounds may treat ocular, neurodegenerative disorders"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p><TABLE border=\"0\" width=\"150\" cellspacing=\"10\" align=\"right\"><br \/>\n<TR><br \/>\n<TD><br \/>\n<img decoding=\"async\" src=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/kador.jpg\" border=\"0\" align=\"right\" alt=\"picture disc.\"><br \/>\n<\/TD><br \/>\n<\/TR><br \/>\n<TR><br \/>\n<TD><br \/>\n<font face=\"arial\" size=\"1\"><br \/>\nPeter Kador, Ph.D.<br \/>\n<\/FONT><br \/>\n<\/TD><br \/>\n<\/TR><br \/>\n<\/TABLE><I>EDITOR&#8217;S NOTE: This is the third of three stories that have run in UNMC Today this week that focus on the Biotechnology Industry Organization (BIO) Convention, the largest biotechnology event in the world, to be held this week in San Diego. A team from UNMC will join a number of other Nebraska academic, business and industry organizations in showcasing biotechnology innovations during the convention, which will take place in the San Diego Convention Center. The Nebraska group will be among 48 states, 70 countries and 2,200 companies showcasing their displays on the 220,000-foot trade show floor.<\/I> <\/p>\n<p>A UNMC researcher has developed a unique series of compounds that have the potential to treat age-related eye conditions and neurodegenerative disorders.<\/p>\n<p>Peter Kador, Ph.D., a UNMC pharmaceutical science professor, developed a group of multifunctional compounds that act as antioxidants and selective metal chelators. <\/p>\n<p>A chelator is an organic chemical that complexes with and removes free metal ions from solutions. High levels of iron and copper are present in those with Alzheimer&#8217;s and Parkinson&#8217;s disease, cataracts and macular degeneration. <\/p>\n<p>Dr. Kador took one treatment for these disorders &#8212; antioxidants &#8212; and combined them with metal chelators to produce orally active compounds. Once ingested, the compounds enter the eye and brain.<\/p>\n<p>In cultured human lens epithelial cells, these compounds reduced the production of reactive oxygen species (ROS) catalyzed by copper or iron. In addition, they reduced ROS-generated cataract formation in several rodent animal models. Metal-catalyzed ROS formation is believed to be a major cause of these disorders. <\/p>\n<p>&#8220;This is the first orally active series of compounds that both chelate metals and are potent antioxidants that have been shown to get into the retina, lens and brain,&#8221; he said.<\/p>\n<p>Dr. Kador also has found that these compounds appear to prevent radiation damage to the salivary gland. <\/p>\n<p>&#8220;We are excited about the potential that these compounds show for improving the treatment of ROS-mediated disorders&#8221; said Steve Schreiner, Ph.D., senior licensing associate at UNeMed, the technology licensing arm of UNMC.<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>This is the third of three stories that have run in UNMC Today this week that focus on the Biotechnology Industry Organization (BIO) Convention, the largest biotechnology event in the world, to be held this week in San Diego. A team from UNMC will join a number of other Nebraska academic, business and industry organizations in showcasing biotechnology innovations during the convention, which will take place in the San Diego Convention Center.<\/p>\n","protected":false},"author":94,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-32437","post","type-post","status-publish","format-standard","hentry","category-uncategorized","department-unmc-today-todays-headlines","author_override-elizabeth-kumru-unmc-public-affairs"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New compounds may treat ocular, neurodegenerative disorders<\/title>\n<meta name=\"description\" content=\"This is the third of three stories that have run in UNMC Today this week that focus on the Biotechnology Industry Organization (BIO) Convention, the largest biotechnology event in the world, to be held this week in San Diego. 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A team from UNMC will join a number of other Nebraska academic, business and industry organizations in showcasing biotechnology innovations during the convention, which will take place in the San Diego Convention Center.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unmc.edu\/newsroom\/2008\/06\/18\/new-compounds-may-treat-ocular-neurodegenerative-disorders\/\" \/>\n<meta property=\"og:site_name\" content=\"Newsroom\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unmcedu\" \/>\n<meta property=\"article:published_time\" content=\"2008-06-18T05:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.unmc.edu\/newsroom\/wp-content\/uploads\/2022\/08\/kador.jpg\" \/>\n<meta name=\"author\" content=\"Chuck Brown\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@unmc\" \/>\n<meta name=\"twitter:site\" content=\"@unmc\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Chuck Brown\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/\"},\"author\":{\"name\":\"Chuck Brown\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#\\\/schema\\\/person\\\/f99efde0b91c6c20a256357d501c35d3\"},\"headline\":\"New compounds may treat ocular, neurodegenerative disorders\",\"datePublished\":\"2008-06-18T05:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/\"},\"wordCount\":345,\"publisher\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2022\\\/08\\\/kador.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/\",\"url\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/\",\"name\":\"New compounds may treat ocular, neurodegenerative disorders\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/2008\\\/06\\\/18\\\/new-compounds-may-treat-ocular-neurodegenerative-disorders\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.unmc.edu\\\/newsroom\\\/wp-content\\\/uploads\\\/2022\\\/08\\\/kador.jpg\",\"datePublished\":\"2008-06-18T05:00:00+00:00\",\"description\":\"This is the third of three stories that have run in UNMC Today this week that focus on the Biotechnology Industry Organization (BIO) Convention, the largest biotechnology event in the world, to be held this week in San Diego. 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