{"id":32459,"date":"2008-06-20T00:00:00","date_gmt":"2008-06-20T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2008\/06\/20\/researchers-at-unmc-receive-12-million-boost-in-funding\/"},"modified":"2008-06-20T00:00:00","modified_gmt":"2008-06-20T05:00:00","slug":"researchers-at-unmc-receive-12-million-boost-in-funding","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2008\/06\/20\/researchers-at-unmc-receive-12-million-boost-in-funding\/","title":{"rendered":"Researchers at UNMC receive $12 million boost in funding"},"content":{"rendered":"


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\nHoward Gendelman, M.D.
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\n<\/TABLE>The field of neurodegenerative research at UNMC just got a $12 million boost in funding. <\/p>\n

Researchers in the UNMC Department of Pharmacology and Experimental Neuroscience (PEN) have secured funding for seven grants from the National Institutes of Health (NIH) and a pharmaceutical company to study three distinct areas related to neurodegenerative disorders. <\/p>\n

The grants are a significant contribution to the already growing body of neuroscience research developed by the department in recent years. Lead scientists include Howard Gendelman, M.D., chairman of the department; Georgette Kanmogne, Ph.D., associate professor; Jialin Zheng, M.D., associate professor; and James Haorah, Ph.D., assistant professor. <\/p>\n

Four of the grants exceed $1 million.<\/p>\n

The largest grant is a $5.8 million program project grant led by Dr. Gendelman that pulls together the work of several investigators who study therapeutic immune-based strategies for improved drug delivery to the brain.<\/p>\n

Nanoparticles are the focus of a $2.3 million grant that looks at ways to improve the delivery of anti-retroviral drugs commonly used to treat HIV. <\/p>\n

Another grant for $1.8 million looks into therapeutic immunization to promote neuroprotection from Parkinson’s disease and HIV-associated dementia. <\/p>\n

Four additional grants secured by other members of the department look at neurodegeneration related to AIDS and alcohol consumption, and drug development for Parkinson’s disease. <\/p>\n

“Through vision and growth, we have evolved into an interdisciplinary team spanning neuroscience, immunology and pharmacology research,” Dr. Gendelman said. <\/p>\n

In addition to the four lead scientists, other investigators include:
\n

  • Michael Boska, Ph.D., professor and head of radiology research;
    \n
  • Tsuneya Ikezu, M.D., Ph.D., associate professor;
    \n
  • Pawel Ciborowski, Ph.D., assistant professor;
    \n
  • R. Lee Mosley, Ph.D., associate professor;
    \n
  • Larisa Poluektova, M.D., Ph.D., associate professor; and
    \n
  • Yuri Persidsky, M.D., Ph.D., a former UNMC professor who is the newly named chairman of the department of pathology and laboratory medicine at Temple University in Philadelphia.<\/UL> <\/p>\n

    The grants, the investigators working on them and a brief description of each follows:<\/p>\n

    Neural Immunity in HIV Dementia, a program project grant<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> Howard Gendelman, M.D.
    \n
    Funding Source: <\/B> NIH, National Institute of Neurological Disorders and Stroke
    \n
    Amount: <\/B> $5.8 million over five years<\/p>\n

    This grant proposes to use the intracellular processes in the brain to harness the immune responses created by it as a therapeutic benefit for people with HIV-induced dementia.<\/p>\n

    Nanomedicine and NeuroAIDS<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> Howard Gendelman, M.D.
    \n
    Funding Source: <\/B> NIH, National Institute of Neurological Disorders and Stroke
    \n
    Amount: <\/B> $2.3 million over five years<\/p>\n

    This grant will use nanomedicine to deliver commonly used antiretroviral therapies directly to diseased brain tissue. <\/p>\n

    Neuroprotective immunity and HIV dementia<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> Howard Gendelman, M.D.
    \n
    Funding Source: <\/B> NIH, National Institute of Neurological Disorders and Stroke
    \n
    Amount: <\/B> $1.8 million over five years<\/p>\n

    The current proposal will study the mechanisms of how the immune system can be regulated to protect the brain despite a relentless attack by the virus.<\/p>\n

    Blood brain barrier immune compromise in NeuroAIDS<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> Georgette Kanmogne, Ph.D.
    \n
    Funding Source: <\/B> NIH, National Institute of Mental Health
    \n
    Amount: <\/B> $1.4 million over five years<\/p>\n

    This grant will focus on understanding how HIV damages the brain’s protective blood brain barrier, enters the brain and causes dementia.<\/p>\n

    Alcohol abuse and blood-brain barrier dysfunction: Underlying mechanisms<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> James Haorah, Ph.D.
    \n
    Funding Source: <\/B> NIH, National Institute on Alcohol Abuse and Alcoholism
    \n
    Amount: <\/B> $385,876 for two years<\/p>\n

    This grant will study the mechanism of alcohol abuse disruption of the blood brain barrier.<\/p>\n

    Clade Diversity and Macrophage Mediated Neurotoxicity in HIV-1 Dementia<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> Jialin Zheng, M.D.
    \n
    Funding Source: <\/B> NIH, National Institute of Mental Health
    \n
    Amount: <\/B> $416,375 for two years<\/p>\n

    This study will look at the difference between two subtypes of HIV and the potential implications of those differences for HIV-induced dementia. <\/p>\n

    Drug Development and Testing for Parkinson’s disease<\/B><\/I><\/U>
    \n
    Principal Investigator: <\/B> Howard Gendelman, M.D.
    \n
    Funding source: <\/B> BioLine RX
    \n
    Amount: <\/B> $126,000 for one year<\/p>\n

    This study seeks to improve the current treatment regimens offered for Parkinson’s disease. <\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

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