{"id":37657,"date":"2011-01-19T00:00:00","date_gmt":"2011-01-19T06:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2011\/01\/19\/growing-clinical-research-clinical-trials-give-hope\/"},"modified":"2011-01-19T00:00:00","modified_gmt":"2011-01-19T06:00:00","slug":"growing-clinical-research-clinical-trials-give-hope","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2011\/01\/19\/growing-clinical-research-clinical-trials-give-hope\/","title":{"rendered":"Growing clinical research — clinical trials give hope"},"content":{"rendered":"

Parkinson’s disease literally wiped the smile from Nellie Faye Hagberg’s face. <\/p>\n

Her smile had greeted thousands of East Africans where she and husband, Ray, were missionaries for 36 years. It gave hope and courage to her three children, all born and raised in Africa. <\/p>\n

About 20 years ago, the disease began to mask her gregarious nature. <\/p>\n


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\nNellie Hagberg<\/span>
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\n<\/TABLE>Her face deadpanned, as muscles grew taut. Pain in her neck and shoulder lead her to a neurologist, who diagnosed the disease.<\/p>\n

Now, her smile has returned thanks to an experimental drug taken since April through a clinical trial at UNMC. <\/p>\n

“I feel like my old self again,” said Hagberg, 74. “I have more energy, more life. This medicine has allowed me to regain my sense of self.”<\/p>\n

Parkinson’s disease, a degenerative disorder that kills dopamine-producing brain cells, causes tremors, stiffness, slowness and impaired balance. <\/p>\n

About one million Americans have Parkinson’s and there is no cure — though medications provide some relief. <\/p>\n


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\nA researcher’s perspective
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\nRead UNMC Today on Thursday for a Q&A with a campus clinical researcher.
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\n<\/TABLE>At UNMC, Hagberg is one of two participants in a multi-institutional clinical trial to test the effectiveness and safety of a gel form of the drug levodopa-carbidopa. Although not accepting more patients at UNMC, the trial eventually will enroll 320 people globally. John Bertoni, M.D., professor of neurological sciences, is the principal investigator at UNMC.<\/p>\n

The oral tablet form of levodopa-carbidopa is the primary drug prescribed in the United States, but may not be absorbed efficiently, said Carolyn Peterson, nurse coordinator of the trial.<\/p>\n

The gel form, marketed in Europe but not in the U.S., is pumped directly into the small intestine where it is absorbed into the bloodstream. <\/p>\n


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\nMore trials\/Skate-a-thon
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\nFind other clinical trials at UNMC<\/a>.<\/p>\n

Also, register<\/a> to participate in the Jan. 28-29 UNMC Skate-a-thon for Parkinson’s Disease.
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\n<\/TABLE>For the trial, Hagberg had a tube inserted into her stomach. She carries the pump and medicine in a pouch slung over her neck and shoulder.<\/p>\n

Every 40 days, she travels four hours from her Spencer, Neb., home to get a supply of medicine. This will continue for the next four years or until the drug gains approval in the U.S.<\/p>\n

She looks forward to continuing in trials for this medication.<\/p>\n

“We can only make advances in medical care when people are willing to take a risk,” Hagberg said. “Somebody has to do it, why not me?”<\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"

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