{"id":38720,"date":"2011-08-08T00:00:00","date_gmt":"2011-08-08T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2011\/08\/08\/unmc-receives-1-2-million-grant-to-look-at-best-treatment-for-urgent-health-problem\/"},"modified":"2022-08-22T16:17:15","modified_gmt":"2022-08-22T21:17:15","slug":"unmc-receives-1-2-million-grant-to-look-at-best-treatment-for-urgent-health-problem","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2011\/08\/08\/unmc-receives-1-2-million-grant-to-look-at-best-treatment-for-urgent-health-problem\/","title":{"rendered":"UNMC receives $1.2 million grant to look at best treatment for urgent health problem"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><div style=\"margin: 0in 0in 0pt\">The University of Nebraska Medical Center has received a $1.2 million grant to participate in a five year clinical research study to compare the effectiveness of treatments for patients with catheter-associated staphylococcus infections &#8211; also called bloodstream infections or sepsis. The study, funded by the National Institutes of Health, is led by Duke University Medical Center and will involve 500 hospitalized patients at five medical centers in the United States and one in Europe.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">The impetus for the study is antibiotic resistance is at an all-time high and development of new antibiotics is at an all-time low.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">&#8220;Increasing antibiotic resistance and decreasing new drug discovery are like two trains speeding down the track toward a collision. When the collision occurs, we&#8217;ll have patients with infections due to resistant bacteria that we are not able to\u00a0treat with any antibiotic,&#8221; said Mark Rupp, M.D., chief of the UNMC section of infectious diseases and medical director of The Nebraska Medical Center Department of Healthcare Epidemiology.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">Staphylococci &#8211; also referred to as staph &#8212; are the most frequent cause of catheter-associated infections. According to the Centers for Disease Control and Prevention, among the 80,000 patients acquiring infections due to catheters each year, about 8,000 to 10,000 die.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">In the study, health professionals will use an algorithm &#8212; a treatment formula or clinical roadmap &#8211; to treat hospitalized patients with staph infections acquired through central venous catheters. It stipulates what tests to run, and depending on what species of staph the patient has, what treatment to use and for how long.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">&#8220;This is an important project. We&#8217;re trying to figure out if we can use the algorithm to effectively treat patients and limit the unnecessary use of vancomycin, a leading antibiotic. We know some patients get vancomycin for longer than they need,&#8221; Dr. Rupp said. &#8220;We&#8217;re trying to figure out where that sweet middle ground is of treating patients with the right antibiotic for the right amount of time rather than under- or over-treating them.&#8221;<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">Central venous catheters are inserted in large central veins, such as in the arm, neck, leg, or under the collarbone. They enable health professionals to deliver drug treatment, hydration or sustenance for weeks or even months.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">&#8220;Right now, treatment is left up to the judgment of the primary team seeing the patient,&#8221; said Dr. Rupp, principal investigator of the UNMC study and a member of the UNMC Center for Staphylococcal Research. &#8220;The algorithm, which was developed based on years of research and expert opinion, stipulates what tests to run and what should be in the decision-making process. We think this is a better way of driving the decision of the length of therapy.&#8221;<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">Staph infections generally stem from bacteria that thrive on human skin. The bacteria gain access to the bloodstream through the outer or inner surface of the catheter.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">&#8220;That is why it is critically important to insert catheters using careful, sterile technique, then care for the catheters meticulously. It&#8217;s crucial to disinfect the catheter access port or hub each and every time the catheter is used to draw blood or administer medications,&#8221; Dr. Rupp said.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\">A short video (about one minute) of <a href=\"http:\/\/www.youtube.com\/watch?v=k-6FOey8glY\">Dr. Rupp talking about the new study and why it&#8217;s important is available on YouTube at<\/a> <a href=\"http:\/\/youtu.be\/k-6FOey8glY\">http:\/\/youtu.be\/k-6FOey8glY<\/a>. Dr. Rupp also shares tips about how you can prevent a catheter infection. Watch a 54 second\u00a0video of Dr. Rupp on YouTube at http:\/\/youtu.be\/rWaO-tSOKJU.<\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"margin: 0in 0in 0pt\"><i><span style=\"font-size: 9pt\">Through world-class research and patient care, UNMC generates breakthroughs that make life better for people throughout Nebraska and beyond. Its education programs train more health professionals than any other institution in the state. Learn more at unmc.edu. <\/span><\/i><\/div>\n<div style=\"margin: 0in 0in 0pt\">\u00a0<\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Study to compare treatments for  staphylococcus infections 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