{"id":38785,"date":"2011-08-24T00:00:00","date_gmt":"2011-08-24T05:00:00","guid":{"rendered":"https:\/\/www.unmc.edu\/newsroom\/2011\/08\/24\/unmc-researchers-developing-more-effective-drug-delivery-for-hiv\/"},"modified":"2022-08-22T16:17:14","modified_gmt":"2022-08-22T21:17:14","slug":"unmc-researchers-developing-more-effective-drug-delivery-for-hiv","status":"publish","type":"post","link":"https:\/\/www.unmc.edu\/newsroom\/2011\/08\/24\/unmc-researchers-developing-more-effective-drug-delivery-for-hiv\/","title":{"rendered":"UNMC researchers developing more effective drug delivery for HIV"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><div style=\"line-height: normal;margin: 0in 0in 0pt\"><b><i><span>Instead of multiple pills each day, patients would receive one weekly injection<\/span><\/i><\/b><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><b>\u00a0<\/b><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>A <a href=\"http:\/\/www.unmc.edu\/\">University of Nebraska Medical Center<\/a> research team is making strides in developing weekly injectable antiretroviral therapy (ART) for patients with human immunodeficiency virus (HIV) infection. This is a potential alternative for the daily regimen of pills that patients are now taking. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>The research is being funded as a three-year, $4.6 million pilot grant from the <a href=\"http:\/\/www.nida.nih.gov\/NIDAHome.html\">National Institute on Drug Abuse <\/a>at the <a href=\"http:\/\/nih.gov\/\">National Institutes of Health<\/a>. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span><a href=\"http:\/\/www.unmc.edu\/publicrelations\/HowardGendelman.htm\">Howard Gendelman, M.D.,<\/a> professor and chairman of the <a href=\"http:\/\/www.unmc.edu\/pharmacology\/\">department of pharmacology and experimental neuroscience<\/a> at the University of Nebraska Medical Center, is the lead investigator. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>In the first year, the research team &#8211; made up of two UNMC colleges, four departments, and two universities &#8211; has been successful in developing a lead drug formulation in rodents. Testing is now underway in larger animals. Human use will require <a href=\"http:\/\/www.fda.gov\/\">Food and Drug Administration (FDA)<\/a> approval. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>Dr. Gendelman said the long-acting ART is a substantive breakthrough for HIV patients. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>&#8220;Having a single injection for treatment would facilitate compliance of complex dosing regimens and be quite beneficial to patients who cannot take the drugs orally,&#8221; Dr. Gendelman said. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>&#8220;Compliance is the key to maintaining control of HIV growth. It&#8217;s absolutely critical that patients take their medications. This is especially important in a resource-limited setting such as Africa, where access to drugs is more limited.&#8221;<\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>Suboptimal adherence increases the risk of treatment failure and viral resistance. Importantly, drug abuse is highly correlated with only sporadic adherence to oral dosing and commonly leads to accelerated HIV disease progression. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>In many cases, health care providers are reluctant to prescribe ART to patients who are addicted to drugs because of concerns about the promotion of virus resistance. <\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>The work group included nanoformulation experts, cell biologists, virologists, pharmacologists, pharmacists and clinicians.\u00a0<\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><span>A progress report will be presented to a team of advisors which is visiting UNMC this week. These advisors include representatives from the FDA and leading medical universities and pharmaceutical companies including Purdue University, Johns Hopkins University, University of Pittsburgh, and Baxter Health Care.<\/span><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\"><i><span style=\"color: black;font-size: 10pt\">Through world-class research and patient care, UNMC generates breakthroughs that make life better for people throughout Nebraska and beyond. Its education programs train more health professionals than any other institution in the state. Learn more at unmc.edu. <\/span><\/i><\/div>\n<div style=\"line-height: normal;margin: 0in 0in 0pt\">\u00a0<\/div>\n<p>\u00a0<\/p>\n<!-- <a rel=\"nofollow\" href=\"\/secure-location.php\" title=\" ia Zwd VrdeY mon qLwQtuDDrQc\"> ia Zwd VrdeY mon qLwQtuDDrQc<\/a> --><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Dr. Gendelman lands $4.6 million NIH grant<\/p>\n","protected":false},"author":94,"featured_media":20387,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-38785","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","topic-research","department-college-of-medicine","department-press-release"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNMC researchers developing more 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